Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 978

Special Issue Editor


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Guest Editor
1. Department of Gynecology, Sasaki Foundation Kyoundo Hospital, Tokyo 101-0062, Japan
2. Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Interests: gynecologic oncology; pathogenesis of cervical cancer; HPV preventive vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
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Special Issue Information

Dear Colleagues,

Managing cervical intraepithelial neoplasia (CIN) involves both treatment and follow-up, with HPV eradication strategies focused on preventing future infections through vaccination and early detection by regular screening. Every year, approximately 600,000 women worldwide are diagnosed with cervical cancer, and an estimated 340,000 women died from the disease in 2020. In Japan, however, the number of cervical cancer cases among women aged 20 to 39 is on the rise, alongside an increasing mortality rate. We invite you to submit research to this Special Issue titled “Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer”, exploring the central theme of preventing uterine cervical cancer, divided into primary and secondary prevention. Primary prevention focuses on the use of HPV vaccines, while secondary prevention involves the diagnosis and management of CIN. We invite manuscripts related to vaccine trials (both preclinical and clinical) and strategies for developing more effective HPV vaccines. Our objective is to compile a range of research addressing the various aspects of HPV that could contribute to more effective strategies for eradicating HPV infection. Potential research areas include, but are not limited to, the following:

  • Diagnosis of CIN;
  • Gynecologic and obstetric risks;
  • Therapeutic effects of treatment.

We look forward to receiving your contributions.

You may choose our Joint Special Issue in Cancers.

Dr. Masaru Sakamoto
Guest Editor

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Keywords

  • CIN
  • 9-valent HPV vaccine
  • HPV L2-VLP vaccine
  • HPV therapeutic vaccine
  • endocervical conization
  • laser vaporization
  • PDT

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Published Papers (1 paper)

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Research

15 pages, 947 KB  
Article
Correlation of HPV Status with Colposcopy and Cervical Biopsy Results Among Non-Vaccinated Women: Findings from a Tertiary Care Hospital in Kazakhstan
by Talshyn Ukybassova, Gulzhanat Aimagambetova, Kuralay Kongrtay, Kuat Kassymbek, Milan Terzic, Sanimkul Makhambetova, Makhabbat Galym and Nazira Kamzayeva
Vaccines 2025, 13(11), 1151; https://doi.org/10.3390/vaccines13111151 - 11 Nov 2025
Viewed by 619
Abstract
Background/Objectives: Cervical cancer is one of the most frequent malignancies among women in Kazakhstan, where human papillomavirus (HPV) vaccination was initiated in 2024. Despite the implementation of vaccination and cytology-based screening programs, diagnostic limitations remain, and local evidence linking HPV infection to [...] Read more.
Background/Objectives: Cervical cancer is one of the most frequent malignancies among women in Kazakhstan, where human papillomavirus (HPV) vaccination was initiated in 2024. Despite the implementation of vaccination and cytology-based screening programs, diagnostic limitations remain, and local evidence linking HPV infection to clinical outcomes is scarce. This study aimed to evaluate the correlation between HPV status, cervical cytology results, colposcopic impression, and biopsy results in a non-vaccinated female population. Methods: A cross-sectional study was conducted at the University Medical Center, Astana, between November 2024 and March 2025. A total of 396 women of reproductive age were enrolled. Cervical samples underwent liquid-based cytology and high-risk HPV testing with the RealBest assay. Colposcopy was performed following abnormal cervical cytology results, and colposcopy-guided biopsies were obtained where indicated. Sociodemographic characteristics were assessed, and associations between HPV genotype and clinical outcomes were analyzed using descriptive and inferential statistics. Results: HPV infection was detected in 140 women (35.4%). HPV-16 was the most common genotype (11.4%), followed by HPV-52 (6.6%) and HPV-33 (5.3%). Among 198 women evaluated by colposcopy, abnormal findings were observed in 72.2%, with HPV-16 showing a significant association with higher-grade abnormalities (p < 0.001). Biopsies were available for 40 participants: 12 had CIN I, 12 had CIN II, 10 had CIN III, and 4 had carcinoma in situ. HPV-16 was the only genotype significantly linked to CIN II/III lesions. Conclusions: HPV-16 was strongly associated with abnormal colposcopic findings and high-grade histology, underscoring its oncogenic importance. The prevalence of HPV-52 and HPV-33 further supports the need for HPV nonavalent vaccination. These findings highlight the importance of HPV-based screening, genotype-specific triage, and expanded vaccination to reduce cervical cancer incidence in Kazakhstan. Full article
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