Advances in Epitope-Based Vaccine Design
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Adjuvants".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 13805
Special Issue Editors
Interests: computer aided vaccine design for bacterial; viral and parasitic pathogens; computational biology; Artificial Intelligence in vaccine design
Special Issues, Collections and Topics in MDPI journals
Interests: computer aided vaccine design for bacterial; viral and parasitic pathogens; medical microbiology; computational biology; Artificial Intelligence in vaccine design
Special Issues, Collections and Topics in MDPI journals
Interests: computer aided vaccine design for bacterial; viral and parasitic pathogens; medical microbiology; computational biology; Artificial Intelligence in vaccine design
Special Issue Information
Dear Colleagues,
Conventional vaccines are developed from live attenuated or inactivated organisms, which elicit strong humoral and cellular immunity, resulting in long lasting immunity. However, the use of such vaccines has been questioned due to crucial safety concerns, as the used pathogen may become reactivated. Similarly, subunit-based vaccines containing a single whole protein are also not a good choice because of non-specific immune responses, which may occur due to the presence of multiple antigenic determinants. In addition, the formulation of such vaccines often lead to reactogenic and/or allergenic responses that are often not desired. The design of epitope-driven or peptide-based vaccines is more attractive; they are comparatively easier to produce and construct, they lack any infectious potential, and offer chemical stability. Moreover, for proper engagement of cellular and humoral immunity, a combining task for different peptides is more appreciated. The construction of multi-epitope vaccines by linking the safest and B-cell derived T-cell antigenic epitope offers many significant benefits. These include broader intrinsic immunogenicity, both humoral and cellular immunity can properly be engaged and improve T-cell epitopes population coverage. The novel combination of immuno-informative approaches, together with the knowledge of host immune responses and the exponential increase in complete genome sequencing of pathogen strains, now makes it possible to select the most antigenic epitopes. As such, it is conceived that cocktails of selected and defined epitopes may provide foundations for the rational design of vaccines capable of eliciting convenient cellular and humoral immunity.
This Special Issue aims to detail the advancemes in the epitope-based vaccines development. The Special Issue covers said vaccine development both on computational and experimetnal techniques for variety of pathogens as well as cancer diseases.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:
- Computational design of epitope based vaccines;
- Experimental design of epitopes based vaccines.
We look forward to receiving your contributions.
Dr. Sajjad Ahmad
Dr. Muhammad Khurram
Dr. Sumra Wajid Abbasi
Guest Editors
Manuscript Submission Information
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Keywords
- vaccines
- Eptiope vaccines
- bacteria
- viruses
- parasites
- cancer
- animal model
- immunity
- cellular immunity
- bioinformatics
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