Special Issue "Drug Development Using Natural Toxins"

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editor

Prof. Dr. Gihyun Lee
E-Mail Website
Guest Editor
College of Korean Medicine, Dongshin University, Naju, 58245, Korea
Interests: venom; drug discovery; pharmacology; herbal medicine; immune response

Special Issue Information

Dear Colleagues,

Natural toxins are poisonous substances produced by bacteria, insects, animals, or plants. They cause pain, disease, and even death to victims, but they also provide humans with a rich resource for new drugs for a variety of targets, from pain to lethal diseases.

Toxins have long been used to treat diseases globally, but they have not been studied enough as a drug candidate. Bee venom, one of the most widely used toxins used for therapeutic purposes, still applies to efficacy and safety as a remedy for many diseases. It is at the beginning stage of drug development studies, with other poisons such as those from snake, scorpion, and toad venoms. Toxic medicinal plants, which have been used in traditional medicine for a long time, are highly valuable in drug development as well as in treating various diseases.

This Special Issue aims to provide a comprehensive view of natural toxins having therapeutic potential. We hope that researchers will share their valuable studies using natural toxins for drug development.

Prof. Dr. Gihyun Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxin
  • venom
  • drug development
  • therapeutic application
  • medicine

Published Papers (1 paper)

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Research

Open AccessCommunication
Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in Mice
Toxins 2020, 12(1), 16; https://doi.org/10.3390/toxins12010016 - 30 Dec 2019
Abstract
Ephedra sinica Stapf (EH) exert toxic effects, such as excitability, cardiac arrhythmia, and others. On the contrary, in traditional herbal medicine, EH and gypsum (GF) are used most often to treat symptoms caused by external stressors. The hypothalamus plays a crucial role in [...] Read more.
Ephedra sinica Stapf (EH) exert toxic effects, such as excitability, cardiac arrhythmia, and others. On the contrary, in traditional herbal medicine, EH and gypsum (GF) are used most often to treat symptoms caused by external stressors. The hypothalamus plays a crucial role in thermal homeostasis. Inflammatory response in the hypothalamus by thermal stressors may affect thermal and energy homeostasis. This study investigates the effect of EH and GF against heat-induced mouse model. Mice were divided into four groups: saline, saline plus heat, EH plus heat, and GF plus heat treated groups. Heat stress was fixed at 43 °C for 15 min once daily for 3 days. Weight and ear and rectal temperature measurements were made after terminating heat stress. Hypothalamus tissue was collected to evaluate the HSP70, nuclear factor kappa-Β (NF-kB), and interleukin (IL)-1β protein expression levels. EH and GF treatment suppressed the increased body temperature. EH significantly ameliorated heat-induced body weight loss, compared to gypsum. Regulatory effects of EH and GF for body temperature and weight against heat stress were mediated by IL-1β reduction. EH showed significant HSP70 and NF-kB inhibition against heat stress. EH and GF contribute to the inhibition of heat-induced proinflammatory factors and the promotion of hypothalamic homeostasis. Full article
(This article belongs to the Special Issue Drug Development Using Natural Toxins)
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