Special Issues

Pharmaceutics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing HIV Prevention and Treatment: Pharmacokinetics, Pharmacodynamics, Toxicokinetics, Formulation and Delivery of Antiretroviral Drugs
edited by Julie B. Dumond
submission deadline 31 Oct 2025 | Viewed by 53 | Submission Open
Keywords: long-acting injectable antiretrovirals; PK/PD modeling of antiretrovirals; predictions of HIV PrEP effectiveness; antiretroviral toxicokinetics; novel drug delivery systems; novel dosing strategies; HIV treatment or prevention therapeutics in development; clinical pharmacokinetic studies in key populations; HIV drug delivery innovations; mannose receptor-targeted delivery
(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)
Design, Development and Biomedical Applications of Hyaluronic Acid-Based Drug and Gene Delivery Systems
edited by Cristina Casadidio and Alice Spadea
submission deadline 31 Oct 2025 | Viewed by 48 | Submission Open
Keywords: hyaluronic acid; targeted drug delivery; gene delivery; CD44; nucleic acid delivery; HA conjugates; nanoparticles personalized medicine
(This special issue belongs to the Section Gene and Cell Therapy)
PLGA Micro/Nanoparticles in Drug Delivery
edited by Ilaria Arduino and
submission deadline 10 Nov 2025 | 2 articles | Viewed by 2162 | Submission Open
Keywords: micro- and nanotechnology; particle manufacturing; targeted delivery; particle characterization; biocompatibility; solubility enhancement
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Recent Advances in Hepatic-Targeted Drug Delivery Systems submission deadline 10 Nov 2025 | Viewed by 783 | Submission Open
Keywords: hepatic drug delivery; phytotherapy; nanomedicine; lipid complexes; targeted therapies; liver diseases; drug vehicles; biomaterials; hepatocellular carcinoma; liposome; polymeric nanoparticles; lipid nanoparticles; hepatic stellate cell
(This special issue belongs to the Section Drug Targeting and Design)
Bioavailability and Bioequivalence Assessment of Topical Drug Products Intended for Local Action
edited by and Seeprarani Rath
submission deadline 15 Nov 2025 | Viewed by 41 | Submission Open
Keywords: bioequivalence; bioavailability; biowaivers; topical dosage forms for local action; topical corticosteroids; dermatopharmacokinetics; in vitro release tests (IVRTs)/in vitro permeation tests (IVPTs); pharmaceutical equivalence; semi-solid dosage forms; human skin; vasoconstrictor assay (VCA) in place of human skin
(This special issue belongs to the Section Biopharmaceutics)
Pathophysiological Influences on Pharmacokinetics and Pharmacodynamics
edited by Geraldo Duarte, Fernanda de Lima Moreira and Jhohann Richard de Lima Benzi
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4064 | Submission Open
Keywords: drug– disease interactions; pharmacokinetics; pharmacodynamics; pharmacotherapy
(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)
Novel Drug Delivery Systems for the Treatment of Skin Disorders submission deadline 20 Nov 2025 | 2 articles | Viewed by 2491 | Submission Open
Keywords: drug delivery; nanoparticles; vesicular systems; 3D-printed drugs; topical dosage form; skin disorder; penetration
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Nanotechnology and RNA-Based Technologies Applied to Prophylaxis and Advanced Therapies
edited by and Vinicius Pinto Costa Rocha
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2144 | Submission Open
Keywords: RNA-technologies; nanotechnology; messenger RNA (mRNA); interference RNA (RNAi); vaccines; treatment
(This special issue belongs to the Section Gene and Cell Therapy)
Long Acting Drug Delivery Formulations
edited by Thierry Vandamme
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1994 | Submission Open
Keywords: improvement in patient adherence; steady state; drug bioavailability; reduced side effect; targeted delivery; long acting; sustained release; prolonged release; pulse release; compliance
(This special issue belongs to the Section Physical Pharmacy and Formulation)
Biomaterials: Pharmaceutical Applications
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 677 | Submission Open
Keywords: natural biomaterials; synthetic biomaterials; drug delivery systems; tissue engineering; disease diagnosis; wound healing
(This special issue belongs to the Section Biopharmaceutics)
Recent Advances in Drug Formulation for Antiviral Therapy
edited by Chiara Medaglia
submission deadline 20 Nov 2025 | Viewed by 344 | Submission Open
Keywords: antiviral drugs development; infection; host-pathogen interactions; functional genomics
(This special issue belongs to the Section Drug Targeting and Design)
“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes submission deadline 20 Nov 2025 | Viewed by 117 | Submission Open
Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy
(This special issue belongs to the Section Drug Targeting and Design)
Antibody–Drug Conjugates Therapeutics submission deadline 20 Nov 2025 | Viewed by 111 | Submission Open
Keywords: antibody– drug conjugate; drug delivery; antibody; payload; linker; protein conjugation
(This special issue belongs to the Section Biologics and Biosimilars)
Drug Product Performance: Bioavailability, Relative Bioavailability and Bioequivalence, 2nd Edition
edited by
submission deadline 30 Nov 2025 | 9 articles | Viewed by 12314 | Submission Open
Keywords: bioavailability; relative bioavailability; bioequivalence; biowaivers; statistical issues; regulatory issues; in vitro– in vivo correlations; physiologically-based biopharmaceutical models; physiologically-based pharmacokinetic models; qualification of models; population pharmacokinetic models; biopharmaceutical classification system; in vitro dissolution; dissolution metrics; predictive dissolution; clinical trial simulations; clinical trial optimization; healthy subjects in BA/BE trials; patients in BA/BE trials; pharmacokinetic parameters for BA/BE assessment; narrow therapeutic index drugs; highly variable drug products; immediate-release formulations; modified-release formulations; multiphasic drug products; extravascular routes of administration
(This special issue belongs to the Section Biopharmaceutics)
Inorganic Nanomaterials for the Development of Drug Delivery and Biomedical Applications
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5521 | Submission Open
Keywords: inorganic nanoparticles; drug delivery; disease diagnosis; disease treatment; nano-biosensor; cancer theranostics; cancer imaging
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Advances in Drug Delivery Systems for the Treatment of Chronic Wound Healing
edited by Carolina Martinez and María Jimena Prieto
submission deadline 30 Nov 2025 | 5 articles | Viewed by 5324 | Submission Open
Keywords: wound healing; chronic diseases; wound repair and regeneration; drug delivery; topical formulations; biomaterial; nanotechnology; wound dressing; scar
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Hybrid Nanoparticles for Cancer Therapy
edited by Jacy Gameiro
submission deadline 30 Nov 2025 | 4 articles | Viewed by 3740 | Submission Open
Keywords: hybrid nanoparticles; cancer therapy; targeted drug delivery; nanomedicine; tumor microenvironment; gene therapy; immunotherapy; diagnostics; nanomaterials
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Brain Tumors Treatment: Current and Future Challenges from Drug Formulations to Delivery Methods
edited by , Sara Badodi and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2920 | Submission Open
Keywords: blood– brain barrier pathophysiology in different tumors; pediatric brain tumors; adult brain tumors; considerations for adult vs. pediatric drug delivery development; nanocarriers and nanoparticles; focused ultrasound; convection enhanced delivery; intranasal delivery; intra-arterial delivery; combination strategies
(This special issue belongs to the Section Drug Targeting and Design)
Naturally Derived Materials-Based Drug Delivery Systems and Their Biomedical Applications
edited by and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2872 | Submission Open
Keywords: naturally derived material; drug delivery systems; tissue engineering; regenerative medicine
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Microneedles for Drug and Vaccine Delivery
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2635 | Submission Open
Keywords: physical enhancement technologies; fabrication; characterization; applications; drug delivery; cosmetic applications; diagnostic; vaccination
(This special issue belongs to the Section Drug Delivery and Controlled Release)
In Silico Approaches of Drug–Target Interactions
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1301 | Submission Open
Keywords: in silico drug discovery; drug– target interactions; virtual screening; molecular modeling; machine learning in drug design; ADME predictions
(This special issue belongs to the Section Drug Targeting and Design)
Alternative Animal Models for Nanoparticle-Based Drug Delivery: Efficacy and Toxicity Assessment submission deadline 30 Nov 2025 | 1 articles | Viewed by 1125 | Submission Open
Keywords: alternative animal models; nanoparticle drug delivery; nanomedicine; toxicity assessment; bioavailability; in vivo models; biodistribution studies; therapeutic efficacy; pharmaceutical testing
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Innovative Drug Delivery Systems: From Nanotechnology to Smart Devices
edited by Mahdi Ghavami and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 978 | Submission Open
Keywords: smart nanoparticles; innovative drug delivery; ingestible devices; targeted delivery systems; controlled release; microfabrication techniques; nano and microtechnology; biocompatible materials; bioavailability
(This special issue belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
In Vitro and In Vivo Biopharmaceutics Assessment of Silica-Based Drug Delivery Systems: Characterization, Drug Release, and Biological Performance submission deadline 30 Nov 2025 | 1 articles | Viewed by 829 | Submission Open
Keywords: drug delivery systems; mesoporous silica nanoparticles; biopharmaceutics evaluation; controlled drug release; drug release kinetics; in vivo performance; in vitro methodologies; pharmaceutical nanotechnology; stimuli-responsive systems; therapeutic efficacy
(This special issue belongs to the Section Biopharmaceutics)
Natural Compounds in Drug Delivery Systems submission deadline 30 Nov 2025 | 1 articles | Viewed by 557 | Submission Open
Keywords: natural products; extraction techniques; phytochemical analyses; natural compounds; biological active compounds; new formulations; encapsulated technics; biotechnology; drug delivery systems; bioavailability; pharmacy
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Nanosystems for Advanced Diagnostics and Therapy submission deadline 30 Nov 2025 | 1 articles | Viewed by 549 | Submission Open
Keywords: nanosystems; theranostics; nanomedicine; molecular imaging; targeted drug delivery; radiolabeled nanoparticles; image guided therapy; smart nanocarriers; nanoradiopharmaceuticals; nanotechnology in diagnostics
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Carbon-Based Nanomaterials for Pharmaceutical Applications
edited by and Ivana Borišev
submission deadline 30 Nov 2025 | Viewed by 465 | Submission Open
Keywords: carbon-based nanomaterials; drug delivery; fullerenes; graphene; carbon nanotubes; nanodiamonds; carbon dots; biocompatibility; pharmaceutical applications
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Advancements and Innovations in Antibody Drug Conjugates
edited by , Shivaji Edupuganti and Ebaston Thankarajan
submission deadline 30 Nov 2025 | 1 articles | Viewed by 459 | Submission Open
Keywords: antibody– drug conjugates; monoclonal antibodies; targeted therapies; linker technologies; site-specific conjugation; bioimaging; pharmacokinetics; therapeutic index; next-generation ADCs; drug resistance; bispecific antibodies; combination therapies; off-target toxicity; efficacy and safety; tumor-specific antigens
(This special issue belongs to the Section Drug Targeting and Design)
Controlled Delivery of Cosmeceuticals Using Nanotechnology submission deadline 30 Nov 2025 | Viewed by 411 | Submission Open
Keywords: cosmeceuticals; skin; targeting; cosmetics; nanotechnology; delivery; formulation
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Advances in Solid and Semi-Solid Dosage Form Design for Enhanced Biopharmaceutical Performance submission deadline 30 Nov 2025 | Viewed by 316 | Submission Open
Keywords: solid dosage forms (tablets; capsules; pellets); novel formulation strategies; bioavailability enhancement; amorphous solid dispersions; lipid-based formulations; pharmaceutical cocrystals; excipient functionality and drug release; 3D printing in pharmaceuticals; hot melt extrusion (HME); spray drying in drug formulation; co-processing techniques; controlled and sustained drug release; targeted drug delivery systems; in vitro/in vivo correlation (IVIVC); quality-by-design (QbD) in pharmaceutics
(This special issue belongs to the Section Biopharmaceutics)
Nanoemulsions for Nose-to-Brain Drug Delivery
edited by Clóvis Orlando Pereira Da Fonseca and
submission deadline 30 Nov 2025 | Viewed by 304 | Submission Open
Keywords: nanoemulsion; intranasal; pharmacokinetics; nose-to-brain; neurology; olfactory; nanomedicine
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Developing Drug Delivery Approaches for Both Phage Therapeutics and Phage-Based Vectors
edited by and Daniel De Vos
submission deadline 30 Nov 2025 | Viewed by 280 | Submission Open
Keywords: phage vector; drug delivery; phage therapy; phage technology
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Smart Drug Delivery Systems for Immunotherapeutic Agents submission deadline 30 Nov 2025 | Viewed by 259 | Submission Open
Keywords: immunotherapy; drug delivery systems; nanomedicine; targeted therapy; cancer immunotherapy; lipid nanoparticles; biomaterials; controlled rel ease; immunoengineering; translational medicine
(This special issue belongs to the Section Gene and Cell Therapy)
Advances in Vaccine Delivery and Vaccine Administration submission deadline 30 Nov 2025 | 1 articles | Viewed by 243 | Submission Open
Keywords: vaccine delivery; vaccination; vaccine immunity; humoral immune response; cell-mediated immunity; infectious diseases; vaccine administration; novel routes of vaccination; nanoparticles
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Metal Nanoparticles in Therapeutics: Pioneering Drug Delivery Systems and Tissue Engineering submission deadline 30 Nov 2025 | Viewed by 237 | Submission Open
Keywords: metal nanoparticles; drug delivery systems; tissue engineering; cancer therapy; nanomedicine
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Advancing Block Co-Polymer Nanomedicines: Innovations in Effective Drug Delivery submission deadline 30 Nov 2025 | Viewed by 213 | Submission Open
Keywords: pluronic-based nanomedicines and hydrogels; gene delivery; advanced drug delivery systems; radiotherapy and photodynamic therapy; combination therapy; polymeric nanomedicines; immunotherapy; nanogels; small-molecule delivery systems; block co-polymers nanomedicines
(This special issue belongs to the Section Nanomedicine and Nanotechnology)
Advanced Drug Delivery Systems for Natural Products submission deadline 30 Nov 2025 | Viewed by 165 | Submission Open
Keywords: natural products; advanced drug delivery systems; liposomes; niosomes; phytosomes; lipid nanoparticles; smart polymers; biodegradable nanoparticles; polymeric nanoparticles; drug carriers
(This special issue belongs to the Section Drug Delivery and Controlled Release)
A New Generation of Metal Anticancer Drugs
edited by
submission deadline 30 Nov 2025 | Viewed by 165 | Submission Open
Keywords: metal-based drugs; cytotoxicity; cancer; nanoparticles; drug delivery
(This special issue belongs to the Section Physical Pharmacy and Formulation)
Formulation, Characterization, and Performance Testing of Topical Semisolid Products
edited by and Seeprarani Rath
submission deadline 30 Nov 2025 | Viewed by 141 | Submission Open
Keywords: formulation of topical semisolid dosage forms; characterization of topical semisolid dosage forms; microstructure; in vitro release and permeation testing; bioavailability and bioequivalence; topical and transdermal delivery; quality-by-design
(This special issue belongs to the Section Physical Pharmacy and Formulation)
Biomaterials for Skin Drug Delivery
edited by
submission deadline 30 Nov 2025 | Viewed by 137 | Submission Open
Keywords: skin drug delivery; transdermal delivery; topical delivery; skin permeation; biomaterials; hydrogels; microneedles; nanocarriers; bioresponsive materials
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Biocompatible Polymer-Based Nanocarriers and Nanocomposites as Drug Delivery Systems
edited by
submission deadline 30 Nov 2025 | Viewed by 135 | Submission Open
Keywords: biocompatible nanocomposites; polymer-based nanocomposites; drug delivery; controlled-release systems; nanocarriers; nanomedicine; nanocomposite toxicity; vaccines; gene delivery; cancer therapy; neurodegenerative diseases
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Formulation of Lipid-Based Nanocapsules: Drug Release, Permeability, Biocompatibility, and Stability Studies
edited by and Carolina Arrúa
submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open
Keywords: drug delivery; lipid nanocapsules; permeability; biocompatibility; therapeutic efficacy
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Manipulation of the Blood–Brain Barrier for CNS Drug Delivery Enhancement
edited by David Fortin and
submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open
Keywords: blood– brain barrier (BBB); intra-arterial infusion; BBB manipulation; efflux transporters; CNS delivery
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Novel Therapeutic Agents and Innovative Delivery Systems Against Infectious Diseases
edited by Sara Consalvi
submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open
Keywords: medicinal chemistry; antibacterials; antivirals; antimicrobials; drug resistance; drug delivery; drug candidate; drug repurposing
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Recent Advances in Physiologically Based Biopharmaceutics Modeling
edited by Atsushi Kambayashi
submission deadline 30 Nov 2025 | Viewed by 91 | Submission Open
Keywords: oral drug absorption; bioavailability; bioequivalence; modeling and simulation; physiologically based biopharmaceutics modeling
(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics)
Innovative Therapies for Neurodegenerative Diseases submission deadline 30 Nov 2025 | Viewed by 88 | Submission Open
Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials
(This special issue belongs to the Section Gene and Cell Therapy)
Next-Generation Non-Viral Vectors for Gene Therapy and DNA Vaccination
edited by
submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open
Keywords: non-viral vectors; gene therapy; DNA vectors; plasmid vectors; mRNA vectors; lipid nanoparticles (LNPs); cell-free DNA synthesis; gene electrotransfer; targeted gene delivery; non-viral vector manufacturing; clinical translation of gene therapies
(This special issue belongs to the Section Gene and Cell Therapy)
The Preparation of an Exosome/Liposomal Nano-Drug Delivery System and Its Application in the Treatment of Inflammatory Bowel Disease
edited by and
submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open
Keywords: exosomes; liposomes; nano-drug delivery systems; inflammatory bowel disease (IBD); targeted therapy; mucosal drug delivery; drug encapsulation; immunomodulation; nanomedicine; extracellular vesicles; personalized medicine
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Innovations in Advanced Drug Delivery Systems: Overcoming Challenges for Personalized Medicine
edited by Hélcio Silva Dos Santos
submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: drug administration; polymers; structural characterization; nanoparticles; in silico studies; toxicity; bioavailability
(This special issue belongs to the Section Drug Delivery and Controlled Release)
Anti-Inflammatory Effects from Natural Bioactive Compounds—from Bench to Bedside, 3rd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open
Keywords: inflammation; bioproducts; isolated compounds; cytokines; macrophages; autoimmune diseases; in vivo assay; in vitro assay
(This special issue belongs to the Section Drug Targeting and Design)
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