Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.9
4.9
Journals
Pharmaceutics
Special Issues
Controlled-Release Drug Delivery Systems for Anti-Inflammatory and Wound Healing Action
share announcement

Controlled-Release Drug Delivery Systems for Anti-Inflammatory and Wound Healing Action

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3145

Special Issue Editors

Dr. Vladimir Zivkovic

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
Interests: chronic diseases; metabolic disorders; oxidative stress; inflammation; wound healing pathophysiology; natural products for biomedical application
Dr. Jovana Bradic

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
Interests: natural products; oxidative stress; development of dermocosmetic products; skin emulsions; plant extracts with anti-inflammatory and wound healing potential
Dr. Anica M. Petrović

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
Interests: plant-based products; skin semi-solid formulations; natural antioxidants; wound repair and regeneration; plant extracts and secondary metabolites as anti-inflammatory agents

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this new Special Issue, entitled “Controlled-Release Drug Delivery Systems for Anti-inflammatory and Wound Healing Action”.

Wound healing represents a natural bodily reaction that is formed as a tissue response to injury. The restoration of the structural and functional integrity of injured tissues is a highly coordinated process involving various overlapping phases such as hemostasis, inflammation, proliferation, and maturation. In recent years, drug delivery systems (DDSs) with controlled release have attracted considerable attention in wound healing and inflammation management due to their significant benefits compared to conventional drugs. The advantages of controlled DDSs for oral administration include enhanced bioavailability, the protection of the drug from metabolic deactivation and the maintenance of the drug concentration over a prolonged period. On the other hand, DDSs with controlled release intended for cutaneous application have led to improvements in drug permeation and modified release at a physiologically relevant rate.

The scope of this Special Issue includes the design and assessment of DDSs for the delivery of active compounds in pharmaceutical formulations with the potential to accelerate wound repair and reduce inflammation in various acute and chronic conditions.

This Special Issue welcomes the submission of articles that address the following topics: the development of DDSs; physicochemical characterization; the evaluation of rheological properties; stability tests; and in silico, in vitro and in vivo assessments of their anti-inflammatory and wound-healing effects. Moreover, formulations based on medicinal plants and natural products that act as major sources of wound healing and anti-inflammatory compounds are of particular interest.

Dr. Vladimir Zivkovic
Dr. Jovana Bradic
Dr. Anica M. Petrović
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • controlled drug delivery systems
  • systems for topical delivery
  • physicochemical characterization
  • stability studies
  • rheological properties
  • release and permeation testing
  • anti-inflammatory properties
  • wound-healing properties
  • natural products

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 7070 KiB  
Article
Colon-Targeted Poly(ADP-ribose) Polymerase Inhibitors Synergize Therapeutic Effects of Mesalazine Against Rat Colitis Induced by 2,4-Dinitrobenzenesulfonic Acid
by Changyu Kang, Jaejeong Kim, Yeonhee Jeong, Jin-Wook Yoo and Yunjin Jung
Pharmaceutics 2024, 16(12), 1546; https://doi.org/10.3390/pharmaceutics16121546 - 2 Dec 2024
Viewed by 1023
Abstract
Background/Objectives: In addition to oncological applications, poly(ADP-ribose) polymerase (PARP) inhibitors have potential as anti-inflammatory agents. Colon-targeted delivery of PARP inhibitors has been evaluated as a pharmaceutical strategy to enhance their safety and therapeutic efficacy against gut inflammation. Methods: Colon-targeted PARP inhibitors 5-aminoisoquinoline (5-AIQ) [...] Read more.
Background/Objectives: In addition to oncological applications, poly(ADP-ribose) polymerase (PARP) inhibitors have potential as anti-inflammatory agents. Colon-targeted delivery of PARP inhibitors has been evaluated as a pharmaceutical strategy to enhance their safety and therapeutic efficacy against gut inflammation. Methods: Colon-targeted PARP inhibitors 5-aminoisoquinoline (5-AIQ) and 3-aminobenzamide (3-AB) were designed and synthesized by azo coupling with salicylic acid (SA), yielding 5-AIQ azo-linked with SA (AQSA) and 3-AB azo-linked with SA (ABSA). Additional conjugation of AQSA with acidic amino acids yielded glutamic acid-conjugated AQSA (AQSA-Glu) and aspartic acid-conjugated AQSA, which further increased the hydrophilicity of AQSA. Results: The distribution coefficients of PARP inhibitors were lowered by chemical modifications, which correlated well with drug permeability via the Caco-2 cell monolayer. All derivatives were effectively converted to their corresponding PARP inhibitors in the cecal contents. Compared with observations in the oral administration of PARP inhibitors, AQSA-Glu and ABSA resulted in the accumulation of much greater amounts of each PARP inhibitor in the cecum. ABSA accumulated mesalazine (5-ASA) in the cecum to a similar extent as sulfasalazine (SSZ), a colon-targeted 5-ASA prodrug. In the DNBS-induced rat colitis model, AQSA-Glu enhanced the anticolitic potency of 5-AIQ. Furthermore, ABSA was more effective against rat colitis than SSZ or AQSA-Glu, and the anticolitic effects of AQSA-Glu were augmented by combined treatment with a colon-targeted 5-ASA prodrug. In addition, the colon-targeted delivery of PARP inhibitors substantially reduced their systemic absorption. Conclusions: Colon-targeted PARP inhibitors may improve the therapeutic and toxicological properties of inhibitors and synergize the anticolitic effects of 5-ASA. Full article
(This article belongs to the Special Issue Controlled-Release Drug Delivery Systems for Anti-Inflammatory and Wound Healing Action)
►▼ Show Figures

Figure 1

23 pages, 8929 KiB  
Article
Development of a Multilayer Film Including the Soluble Eggshell Membrane Fraction for the Treatment of Oral Mucosa Lesions
by Karthik Neduri, Giorgia Ailuno, Guendalina Zuccari, Anna Maria Bassi, Stefania Vernazza, Anna Maria Schito, Gabriele Caviglioli and Sara Baldassari
Pharmaceutics 2024, 16(10), 1342; https://doi.org/10.3390/pharmaceutics16101342 - 19 Oct 2024
Cited by 1 | Viewed by 1499
Abstract
Background/Objectives: Oral diseases causing mucosal lesions are normally treated with local or systemic anti-inflammatory, analgesic and antimicrobial agents. The development of topical formulations, including wound-healing promoters, might speed up the recovery process, improving patients’ quality of life, and reduce the risk of deterioration [...] Read more.
Background/Objectives: Oral diseases causing mucosal lesions are normally treated with local or systemic anti-inflammatory, analgesic and antimicrobial agents. The development of topical formulations, including wound-healing promoters, might speed up the recovery process, improving patients’ quality of life, and reduce the risk of deterioration in health conditions. In this study, a mucoadhesive multilayer film, including a novel biocompatible substance (solubilized eggshell membrane, SESM), was rationally designed. Methods: The SESM preparation procedure was optimized and its biological effects on cell proliferation and inflammation marker gene expression were evaluated in vitro; preformulation studies were conducted to identify the most promising polymers with film-forming properties; then, trilayer films, consisting of an outer layer including chlorhexidine digluconate as a model drug, a supporting layer and a mucoadhesive layer, incorporating SESM, were prepared using the casting method and their mechanical, adhesion and drug release control properties were evaluated. Results: SESM proved to possess a notable wound-healing capacity, inducing a wound closure of 84% in 24 h without inhibiting blood clotting. The films revealed a maximum detachment force from porcine mucosa of approx. 1.7 kPa and maximum in vivo residence time of approx. 200–240 min; finally, they released up to 98% of the loaded drug within 4 h. Conclusions: The formulated trilayer films were found to possess adequate properties, making them potentially suitable for protecting oral lesions and favoring their rapid healing, while releasing antimicrobial substances that might be beneficial in reducing the risk of bacterial infections. Full article
(This article belongs to the Special Issue Controlled-Release Drug Delivery Systems for Anti-Inflammatory and Wound Healing Action)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop