Synergistic Nanomedicines: Integrating Chemotherapy and Phototherapy for Enhanced Cancer Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 558

Special Issue Editor


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Department of Physical and Environmental Sciences, Texas A& M University-Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412-5850, USA
Interests: plasmonics; nanoparticles; nanomedicine; physical chemistry

Special Issue Information

Dear Colleagues,

We are pleased to invite submissions for a Special Issue titled "Synergistic Nanomedicines: Integrating Chemotherapy and Phototherapy for Enhanced Cancer Treatment". This Special Issue aims to explore the intersection of nanotechnology and cancer research, focusing on innovative approaches that combine chemotherapy with photothermal therapy to improve treatment efficacy.

Nanomedicine has revolutionized cancer treatment by offering precise drug delivery systems while minimizing side effects. The integration of chemotherapy and photothermal therapy presents a promising strategy to target cancer cells more effectively, enhancing patient outcomes. This Special Issue will highlight the latest advancements in the design, synthesis, and application of nanomaterials for this synergistic treatment approach.

We welcome contributions covering a wide range of topics, including but not limited to the following:

  • Novel nanomedicine formulations for chemo-photothermal therapy;
  • Mechanistic studies on the synergistic effects of combined therapies;
  • Preclinical and clinical studies demonstrating enhanced treatment efficacy.

We look forward to your valuable contributions to this rapidly growing field.

Dr. Nasrin Hooshmand
Guest Editor

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Keywords

  • nanomaterial
  • nanomedicine
  • chemo-photothermal therapy
  • cancer
  • drug delivery

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Published Papers (1 paper)

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Review

49 pages, 24112 KiB  
Review
Synergistic Cancer Therapies Enhanced by Nanoparticles: Advancing Nanomedicine Through Multimodal Strategies
by Seyed Mohamad Sadegh Mousavi-Kiasary, Ahmood Senabreh, Ashkan Zandi, Rogelio Pena, Frances Cruz, Ali Adibi and Nasrin Hooshmand
Pharmaceutics 2025, 17(6), 682; https://doi.org/10.3390/pharmaceutics17060682 - 22 May 2025
Viewed by 282
Abstract
Cancer remains a formidable global health challenge due to its complex pathophysiology and resistance to conventional treatments. In recent years, the convergence of nanotechnology and oncology has paved the way for innovative therapeutic platforms that address the limitations of traditional modalities. This review [...] Read more.
Cancer remains a formidable global health challenge due to its complex pathophysiology and resistance to conventional treatments. In recent years, the convergence of nanotechnology and oncology has paved the way for innovative therapeutic platforms that address the limitations of traditional modalities. This review examines how nanoparticle (NP)-based strategies enhance the efficacy of chemotherapy, radiotherapy, phototherapy, immunotherapy, and gene therapy by enabling targeted delivery, controlled drug release, and tumor-specific accumulation via the enhanced permeability and retention (EPR) effect. We discuss the design and functionalization of various organic, inorganic, and hybrid NPs, highlighting their roles in improving pharmacokinetics, overcoming multidrug resistance, and modulating the tumor microenvironment. Particular emphasis is placed on dual and multimodal therapies, such as chemo-phototherapy, chemo-immunotherapy, and gene-radiotherapy, that leverage nanoparticle carriers to amplify synergistic effects, minimize systemic toxicity, and improve clinical outcomes. We also explore cutting-edge advances in gene editing and personalized nanomedicine, as well as emerging strategies to address biological barriers and immunosuppressive mechanisms in the tumor niche. Despite the undeniable promise of nanoparticle-based cancer therapies, challenges related to toxicity, scalable manufacturing, regulatory oversight, and long-term biocompatibility must be overcome before they can fully enter clinical practice. By synthesizing recent findings and identifying key opportunities for innovation, this review provides insight into how nanoscale platforms are propelling the next generation of precision oncology. Full article
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