Recent Advances in Nanotechnology-Based Approaches for Pharmaceutical Applications, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 481

Special Issue Editors


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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
Interests: nanomedicine; biomaterials; toxicology; biological response; tissue engineering; materials characterization
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
Interests: nanotoxicology; nanomedicine; proteomics; ceall death; oxidative stress; nanoparticles; gadolinium nanogels; quantum dots; human and murine melanoma animal models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology is a highly advantageous and promising tool that encompasses a wide range of applications in the medical field. For decades, pharmaceutical sciences have used nanoparticles to reduce the toxicity and side effects of drugs. In clinical practice, many nanodrugs are used for both diagnostic and therapeutic applications. Nanoparticles are used in the treatments of kidney diseases, tuberculosis, skin conditions, Alzheimer’s disease and different types of cancer, as well as the preparation of COVID-19 vaccines. Since of engineered nanomaterials have a vast range of chemical compositions, this Special Issue focuses on recent advances in nanomedical applications and new synthesis routes of different types of nanosystems (carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, etc.) designed for pharmaceutics. In this regard, we cordially invite researchers working in relevant fields to submit their innovative contributions on relevant topics. Original research articles and reviews are welcome.

Dr. Ionela Cristina Voinea
Dr. Sorina Nicoleta Petrache Voicu
Guest Editors

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Keywords

  • nanoparticles
  • drug delivery
  • biological barriers
  • pharmaceutical
  • diagnosis
  • therapy
  • efficacy and safety assessment
  • in vitro and in vivo studies

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Published Papers (1 paper)

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45 pages, 4112 KiB  
Review
Recent Advances in Nanotechnology-Based Approaches for Ferroptosis Therapy and Imaging Diagnosis in Pancreatic Cancer
by Xiaoyan Yang, Wangping Luo, Yining Wang, Yongzhong Du and Risheng Yu
Pharmaceutics 2025, 17(7), 937; https://doi.org/10.3390/pharmaceutics17070937 - 20 Jul 2025
Viewed by 149
Abstract
Pancreatic cancer is a highly lethal malignant tumor characterized by challenges in early diagnosis and limited therapeutic options, leading to an exceptionally low clinical cure rate. With the advent of novel cancer treatment paradigms, ferroptosis—a form of iron-dependent regulated cell death driven by [...] Read more.
Pancreatic cancer is a highly lethal malignant tumor characterized by challenges in early diagnosis and limited therapeutic options, leading to an exceptionally low clinical cure rate. With the advent of novel cancer treatment paradigms, ferroptosis—a form of iron-dependent regulated cell death driven by lipid peroxidation—has emerged as a promising therapeutic strategy, particularly for tumors harboring RAS mutations. However, the poor bioavailability and insufficient tumor-targeting capabilities of conventional drugs constrain the efficacy of ferroptosis-based therapies. Recent advancements in nanotechnology and imaging-guided treatments offer transformative solutions through targeted drug delivery, real-time monitoring of treatment efficacy, and multimodal synergistic strategies. This article aims to elucidate the mechanisms underlying ferroptosis in pancreatic cancer and to summarize the latest identified therapeutic targets for ferroptosis in this context. Furthermore, it reviews the recent progress in nanotechnology-based ferroptosis therapy for pancreatic cancer, encompassing ferroptosis monotherapy, synergistic ferroptosis therapy, and endogenous ferroptosis therapy. Subsequently, the integration of imaging-guided nanotechnology in ferroptosis therapy is summarized. Finally, this paper discusses innovative strategies, such as stroma-targeted ferroptosis therapy, immune-ferroptosis synergy, and AI-driven nanomedicine development, offering new insights and directions for future research in pancreatic cancer treatment. Full article
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