Innovative Oral and Topical Drug Delivery Systems for Enhanced Bioavailability

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 2

Special Issue Editors


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Guest Editor
1. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, Consejo Nacional de Investigaciones Científicas y Tecnológicas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Av. Haya de la Torre y Medina Allende, Córdoba 5000, Argentina
2. Pill.AR Apotheke Revolution S.A, Córdoba 5000, Argentina
Interests: materials chemistry; nanotechnology; nanoparticles; vaccines; nanomaterials; gels; surfactants; solid dispersion; formulations; rheology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (UNC), Córdoba X5000HUA, Argentina
2. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET-UNC), Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba X5000HUA, Argentina
Interests: drug delivery; nanomedicine; pediatric formulation

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Guest Editor
Facultad de Ingeniería de la UNSa, INIQUI (Instituto de Investigaciones para la Industria Química), UNSa (Universidad Nacional de Salta), CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Salta 4400, Argentina
Interests: pharmaceutical technology; controlled release; drug delivery systems; drug release; neglected infectious diseases; mathematical modeling

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the development and characterization of oral and topical pharmaceutical formulations designed to enhance the bioavailability of active pharmaceutical ingredients (APIs), particularly those with limited solubility or permeability. The scope encompasses both conventional and advanced drug delivery strategies, designed to enhance absorption, prolong retention at the site of action, and overcome physiological barriers. Emphasis is placed on formulation approaches, including lipid-based systems, polymeric hydrogels, solid dispersions, mucoadhesive platforms, and micro/nanoparticulate carriers. Additionally, contributions addressing the physicochemical optimization, in vitro–in vivo correlation, and innovative techniques for formulation design (e.g., 3D printing or hot-melt extrusion) are welcome. The issue aims to highlight the latest research efforts that contribute to improving the therapeutic performance of oral and topical drug products, with relevance in both pharmaceutical development and clinical practice. 

Prof. Dr. Santiago Daniel Palma
Prof. Dr. Alvaro Jimenez-Kairuz
Dr. José Bermudez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral drug delivery
  • topical formulations
  • bioavailability enhancement
  • polymeric drug delivery systems
  • mucoadhesive systems
  • solubility and permeability improvement
  • in situ forming systems
  • 3D printing in pharmaceutics

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Published Papers

This special issue is now open for submission.
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