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12.5
6.9
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Pharmaceutics
Special Issues
Magnetic Nanoparticles in Regenerative Medicine and Tissue Engineering
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Magnetic Nanoparticles in Regenerative Medicine and Tissue Engineering

A Special Issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: 30 April 2027 | Viewed by 968

Editors

Dr. Mauricio César De Marzi

E-Mail Website
Guest Editor
Grupo de Investigaciones Básicas y Aplicadas en Inmunología y Bioactivos (GIBAIB, INEDES-CONICET), Departamento de Ciencias Básicas, Universidad Nacional de Luján (UNLu), Luján C6700, Argentina
Interests: magnetic nanoparticles; tissue regeneration; wound healing; burn healing
Prof. Dr. Martin Federico Desimone

E-Mail Website
Guest Editor
Facultad de Farmacia y Bioquímica, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires 1113, Argentina
Interests: biomaterials; nanomaterials; 3D printing; tissue engineering; bioinks
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As nanotechnology continues to advance, magnetic nanoparticles (MNPs) have demonstrated remarkable potential in enhancing regenerative therapies and tissue engineering strategies. Therefore, this Special Issue seeks high-quality original research articles, comprehensive reviews, and technical notes exploring the latest advances in the design, synthesis, functionalization, and biomedical applications of magnetic nanoparticles. Topics of particular interest include but are not limited to:

  • Magnetic nanoparticle-based drug delivery systems for regenerative therapies;
  • Magnetically triggered drug release and controlled therapy;
  • Cell tracking and imaging using magnetic nanoparticles;
  • Magnetic hyperthermia and its role in tissue regeneration;
  • Safety, biocompatibility, and clinical translation of magnetic nanomaterials.

We invite researchers, clinicians, and industry experts to contribute their recent findings and insights. This Special Issue aims to foster interdisciplinary collaboration and promote translational research that bridges nanotechnology with regenerative medicine. We encourage the submission of original research articles and reviews focused on specific topics related to magnetic nanoparticles.

We look forward to receiving your contributions.

Dr. Mauricio César De Marzi
Prof. Dr. Martin Federico Desimone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • regenerative medicine
  • tissue engineering
  • targeted drug delivery
  • magnetically responsive scaffolds

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Published Papers (1 paper)

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Research

22 pages, 3494 KB  
Article
3D-Printing of Magnetoactive Gelatin–Alginate Scaffolds
by Sofía Municoy, Exequiel Giorgi, María Edith Farías, Romina B. Currá, Hina N. Chaudhari, Rajshree B. Jotania, Robert C. Pullar, Mauricio De Marzi and Martín F. Desimone
Pharmaceutics 2026, 18(9), 1186; https://doi.org/10.3390/pharmaceutics18091186 (registering DOI) - 19 Sep 2026
Abstract
Background/Objectives: Magnetically responsive biomaterials have emerged as promising platforms for tissue engineering as they allow remote stimulation of cells and improved control over tissue regeneration. Although gelatin–alginate hydrogels incorporating iron oxide nanoparticles have been reported, the use of U-type hexaferrite particles, particularly Al [...] Read more.
Background/Objectives: Magnetically responsive biomaterials have emerged as promising platforms for tissue engineering as they allow remote stimulation of cells and improved control over tissue regeneration. Although gelatin–alginate hydrogels incorporating iron oxide nanoparticles have been reported, the use of U-type hexaferrite particles, particularly Al3+-substituted compositions, remains largely unexplored. This study aimed to develop and characterize extrusion-based 3D-printed gelatin–alginate scaffolds containing U-type hexaferrite particles and to evaluate the influence of particle composition and loading on the rheological, physicochemical and magnetic properties of the resulting biomaterials, as well as their in vitro compatibility with macrophages. Methods: Gelatin–alginate inks containing two U-type hexaferrite compositions (Ba4Co2Fe36−xAlxO60; x = 0.0 and x = 1.0) at two particle loadings (20 and 200 mg) were prepared and processed by extrusion-based 3D printing. The scaffolds were characterized by rheological analysis, SEM-EDS, FTIR, swelling measurements, magnetic responsiveness, and in vitro biological evaluation using RAW264.7 macrophages. Results: The inks exhibited suitable shear-thinning behavior and viscoelastic properties for extrusion-based printing. Increasing particle loading enhanced the thermal resistance of the network, whereas Al3+ substitution modified the viscoelastic response of the polymeric network. The 3D scaffolds successfully responded to an external magnetic field and SEM-EDS confirmed the homogeneous incorporation of hexaferrite particles. The magnetic scaffolds did not compromise macrophage metabolic activity. Conclusions: U-type hexaferrite particles provide an effective strategy for producing 3D-printed magnetically responsive scaffolds with tunable rheological properties without inducing an inflammatory response. The combined modulation of particle composition and loading represents a versatile approach for designing multifunctional inks with potential applications in tissue engineering. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles in Regenerative Medicine and Tissue Engineering)
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