Antibacterial Nanoformulations Based on Natural Products

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 308

Special Issue Editors


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Laboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Departamento de Ciencias y Geografía, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile
Interests: composition of essential oils and their antimicrobial and cytotoxic activity; resinous exudate against microorganisms and cancer; hemisynthetic drugs derived from natural compounds; structural determination of new and known natural molecules; structure-activity relationship of synthetic and natural molecules
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Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile
Interests: nanoemulsiones; formulaciones; natural products; extractos

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Departamento de Ciencias Básicas, Campus Fernando May Universidad del Biobío, Av. Andrés Bello s/n casilla 447, Chillán 3780000, Chile
Interests: biochemistry; cell biology; enzymes

Special Issue Information

Dear Colleagues,

This Special Issue includes in vitro and in vivo studies of the antifungal activity and associated properties of products obtained from native, medicinal, and ornamental plants such as sequential and total extracts, essential oils, resinous exudates, and derivatives of secondary metabolites contained in these products, such as semisynthetic compounds, hybrids, and analogues. With the aim of finding solutions in free state and/or more effective nanoformulates, with less adverse effects and a greater bioavailability of the active principle to face pathologies of fungal origin that increase their incidence year after year affecting humans at clinical, agricultural, and animal levels in pathogenic fungoid that affect productive animals such as bees, salmon, and cattle.

We welcome authors to contribute original articles and reviews that delve into the latest advancements in antimicrobial agents, adjuvants, and drug delivery systems, with a special emphasis on the role of nanotechnology in revolutionizing the treatment and prevention of bacterial infections.

Dr. Alejandro Madrid
Dr. Iván Jose Montenegro Venegas
Dr. Enrique Werner
Guest Editors

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Keywords

  • nanoformulation
  • essential oil
  • extract
  • semisynthetic compound
  • hybrid compound
  • resinous exudate
  • antimicrobial agents
  • natural products

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Published Papers (1 paper)

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Research

13 pages, 2021 KiB  
Article
Nanoemulsion of Gomortega keule Essential Oil: Characterization, Chemical Composition, and Anti-Yeast Activity Against Candida spp.
by Iván Montenegro, Bastián Fuentes, Valentina Silva, Francisca Valdés, Enrique Werner, Rocío Santander, Daniel Moraga-Espinoza and Alejandro Madrid
Pharmaceutics 2025, 17(6), 755; https://doi.org/10.3390/pharmaceutics17060755 (registering DOI) - 8 Jun 2025
Abstract
Background/Objectives: Candidiasis, an opportunistic fungal infection caused by Candida species, is a major health problem, particularly in immunocompromised individuals. Increasing resistance of yeasts such as Candida spp. to pharmacological antifungal agents makes it necessary to explore alternative treatments. The aim of this study [...] Read more.
Background/Objectives: Candidiasis, an opportunistic fungal infection caused by Candida species, is a major health problem, particularly in immunocompromised individuals. Increasing resistance of yeasts such as Candida spp. to pharmacological antifungal agents makes it necessary to explore alternative treatments. The aim of this study was to evaluate the antifungal potential of Gomortega keule essential oil (GKEO) against Candida spp. by assessing growth and development at 24 and 48 h. Encapsulation and characterization of a stable nanoemulsion were carried out to enhance efficacy. Methods: The anti-yeast activity of both free GKEO and the nanoemulsion against Candida albicans, C. glabrata, and C. guilliermondii was evaluated using a microdilution method to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) at 24 and 48 h. Results: GC-MS/MS analysis identified forty-one components in GKEO, the main ones being eucalyptol (21.41%), 4-terpineol (19.62%), and α-terpinyl acetate (13.89%). Antifungal assays revealed that both free and nanoemulsion-formulated GKEO inhibited the growth of all tested Candida strains. At 48 h, the nanoformulated GKEO achieved a MIC value of 32 µg/mL and an MFC of 64 µg/mL for C. albicans and C. glabrata and showed higher antifungal activity compared to the free oil, in particular against C. albicans, exhibiting a four-fold lower MFC value. The activity of the nanoformulation was comparable to or better than fluconazole against C. glabrata and C. guilliermondii. Conclusions: The GKEO nanoemulsion potentiated anti-yeast activity against Candida spp. The formulation improved the efficacy of GKEO, suggesting its potential as an alternative or adjunctive treatment for candidiasis. Full article
(This article belongs to the Special Issue Antibacterial Nanoformulations Based on Natural Products)
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