Microfluidic Devices for Encapsulating and Delivering Large Biomolecules
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 5
Special Issue Editors
Interests: controlled release; solid state properties; organic and inorganic nano- microparticles; inhaled dry powders; drug physical modification; cell microencapsulation and engineering
Special Issues, Collections and Topics in MDPI journals
Interests: polymers; hydrogels; biomaterials; colloids hemostatic materials; polymer capsules; foam; emulsion; porous gels; biopolymers; polymer beads; microfluidics; superabsorbents; absorbents materials; superporous
Special Issue Information
Dear Colleagues,
Microfluidic devices have emerged as a versatile and powerful technique for delivering large biomolecules, including nucleic acids, proteins, and polymers, which are essential for vaccine development, cancer treatment, and cell and protein therapies. These large molecules often face challenges due to their instability, bulkiness, and difficulty in effective delivery. Microfluidics enables precise and scalable encapsulation of these biomolecules into delivery vectors, enhancing their functionality and transport. Technologies such as flow-focusing and chaotic advection-based micromixers, droplet microfluidics, and co-axial systems facilitate the creation of lipid nanoparticles, hydrogel beads, and polymer carriers, all of which can be tailored to release their cargo at targeted organs, thus supporting applications from mRNA delivery to gene editing and cancer immunotherapy. The precise encapsulation of lipid carriers protects nucleic acids, hydrogel beads stabilize proteins, and microgels facilitate tissue regeneration and immune modulation.
In this Special Issue, we invite original research papers and review articles that focus on the advancements and challenges in developing microfluidic devices and methods for the fabrication of state-of-the-art and next-generation nanocarriers for the delivery of biomolecules. Submissions can cover various aspects of microfluidics for large biomolecule delivery, including, but not limited to, recent progress in the manufacturing of lipid and polymeric nanoparticles and biohybrid and biomimetic nanoparticles for protein and nucleic acid delivery. Moreover, cutting-edge applications of microfluidics in areas such as single-cell sequencing and tissue regeneration are welcome.
Dr. Stefano Giovagnoli
Dr. Hema Choudhary
Prof. Dr. Sheng Zhao
Guest Editors
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Keywords
- microfluidics
- lipid nanoparticles
- biohybrid and biomimetic nanoparticles
- nucleic acid delivery
- delivery vectors
- microfluidic mixing
- droplet microfluidics
- protein delivery
- encapsulation
- vaccine development
- microgels
- single-cell sequencing
- biomolecules
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