Recent Advances in Metal-Based Drug Delivery Systems for Cancer Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1568

Editors


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Guest Editor
1. Departamento de Biología, y Geología, Física y Química Inorgánica, Universidad Rey Juan Carlos, Móstoles, Spain
2. Instituto de Investigación en Tecnologías para la Sostenibilidad (ITPS), Móstoles, Madrid
3. Grupo de Investigación COMET-NANO, Móstoles, Madrid
Interests: metallodrugs; platinum; ruthenium; bioinorganic chemistry; coordination chemistry; chemotherapy; photochemistry; drug design

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Guest Editor
Chemistry Department, University of Burgos, Pza. Misael Bañuelos s/n, 09001 Burgos, Spain
Interests: metal complexes; organometallics; bioinorganic chemistry; photodynamic therapy; photoactivated chemotherapy; anticancer drugs; photosensitizer

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue “Recent Advances in Metal-Based Drug Delivery Systems for Cancer Therapy”. Metal-based compounds have long played a pivotal role in oncology, with platinum-based drugs such as cisplatin forming the cornerstone of many chemotherapeutic regimens. However, challenges related to toxicity, resistance, and lack of selectivity have spurred extensive research into novel metal complexes and innovative delivery strategies. This Special Issue aims to showcase the latest developments in the design, synthesis, and application of metal-based agents for targeted and controlled drug delivery in cancer treatment.

Special attention will be given to systems involving prodrugs activated by internal stimuli (such as pH or enzymatic activity) or external triggers (including light or ultrasound), offering precise spatiotemporal control over drug release.

We particularly welcome original research and reviews from interdisciplinary fields such as medicinal chemistry, nanomedicine, materials science, pharmacology, and molecular biology that contribute to the advancement of metal-based drug delivery systems for cancer therapy.

Dr. Maria Jesus Moran Plata
Dr. Marta Martínez-Alonso
Guest Editors

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Keywords

  • metal-based drug delivery systems
  • cancer therapy
  • stimuli-responsive prodrugs
  • nanomedicine
  • coordination complexes
  • targeted chemotherapy

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Published Papers (1 paper)

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Review

10 pages, 1385 KB  
Review
A Cursory Gaze at Solitary Radiopharmaceutical Chelators Incorporating Macrocyclic and Acyclic Moieties
by Stephen Ahenkorah and Danni Ramdhani
Pharmaceutics 2025, 17(12), 1508; https://doi.org/10.3390/pharmaceutics17121508 - 22 Nov 2025
Cited by 1 | Viewed by 1063
Abstract
Radiopharmaceutical development usually requires chelators to route radiometals to specific cancer targets. However, there is no universal chelator. To reduce off-target side effects, new chelators are needed as the radiometal toolset grows. DOTA is the most often used chelator for radiometals in radiopharmaceutical [...] Read more.
Radiopharmaceutical development usually requires chelators to route radiometals to specific cancer targets. However, there is no universal chelator. To reduce off-target side effects, new chelators are needed as the radiometal toolset grows. DOTA is the most often used chelator for radiometals in radiopharmaceutical development, however DOTA’s extreme conditions make it unsuitable for labeling heat sensitive biological vectors. The ideal chelator should be thermodynamically and kinetically stable, allowing labeling under mild conditions (~37 °C). In recent years, new hybrid chelators with enhanced characteristics have emerged, warranting further investigation for medical applications. This paper aims to discuss some of these promising chelators. Full article
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