Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and Applications
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 1370
Special Issue Editor
Special Issue Information
Dear Colleagues,
Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach utilized to predict the absorption, distribution, metabolism, and excretion (ADME) of both synthetic and naturally occurring chemical substances in humans and various animal species. The utility of physiologically based pharmacokinetic (PBPK) models has been substantiated across multiple academic and industrial domains, encompassing stages of drug development, clinical simulations, and regulatory science.
Since its inception and initial phases, this model has exhibited considerable utility in the field of drug development. During the early stages, in vitro data and physicochemical properties can be employed to generate pharmacokinetic profiles, which are subsequently validated through in vivo studies. In the later phases of clinical development, simulations may be utilized to elucidate drug performance within specific populations.
In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following: PBPK modeling and simulation, including the pharmacokinetics of populations, drug–drug interactions, the integration of tissue concentration, PBPK-based precision dosing, PBPK/PD modeling, PBPK-based quantitative systems pharmacology (QSP) approaches, etc.
Dr. Dong‑Gyun Han
Guest Editor
Manuscript Submission Information
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Keywords
- physiologically based pharmacokinetic (PBPK) modeling
- IVIVE
- pharmacokinetics
- ADME
- modeling and simulation
- PK/PD
- biopharmaceutics
- quantitative systems pharmacology
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