Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and Applications

Dear Colleagues,

Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach utilized to predict the absorption, distribution, metabolism, and excretion (ADME) of both synthetic and naturally occurring chemical substances in humans and various animal species. The utility of physiologically based pharmacokinetic (PBPK) models has been substantiated across multiple academic and industrial domains, encompassing stages of drug development, clinical simulations, and regulatory science.

Since its inception and initial phases, this model has exhibited considerable utility in the field of drug development. During the early stages, in vitro data and physicochemical properties can be employed to generate pharmacokinetic profiles, which are subsequently validated through in vivo studies. In the later phases of clinical development, simulations may be utilized to elucidate drug performance within specific populations.

In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following: PBPK modeling and simulation, including the pharmacokinetics of populations, drug–drug interactions, the integration of tissue concentration, PBPK-based precision dosing, PBPK/PD modeling, PBPK-based quantitative systems pharmacology (QSP) approaches, etc.

Dr. Dong‑Gyun Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.