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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Chemical-Biological Knowledge of Essential Oils

edited by

Andrea Maxia

and Emma Cocco

submission deadline 10 Nov 2025 | 4 articles | Viewed by 8563 | Submission Open

Keywords: essential oils (EOs); volatile compounds; chemical composition; biological activity; traditional botanical knowledge

(This special issue belongs to the Section Natural Products)

Therapeutic Potential of Chalcone Derivatives

edited by

Hélcio Silva Dos Santos

submission deadline 10 Nov 2025 | 2 articles | Viewed by 4619 | Submission Open

Keywords: chalcones; pharmacological potential; structural characterization; bioactivity; in silico study; cytotoxicity; quantum chemical calculations; ecapsulation

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals—Ethnopharmacology in Latin America

edited by

Angel Josabad Alonso-Castro

submission deadline 15 Nov 2025 | 8 articles | Viewed by 17267 | Submission Open

Keywords: Latin America; preclinical; clinical; ethnobotany; pharmacology; chemical standardization; herbal products

(This special issue belongs to the Section Natural Products)

Recent Advances in Stomach and Intestinal Drug Delivery Systems

edited by

Agustin Rascon-Chu

submission deadline 15 Nov 2025 | Viewed by 520 | Submission Open

Keywords: stomach delivery; intestinal delivery; meso– nanostructured carriers; micro– nanoparticles/capsules; permeability enhancement; stability; absorption enhancement; gut delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Prostate Cancer

edited by

Benyi Li

submission deadline 15 Nov 2025 | Viewed by 164 | Submission Open

Keywords: prostate cancer; clinical; treatment; prostate cancer imaging; targeted therapy; immunotherapy

(This special issue belongs to the Section Pharmacology)

Optimized or Precise Pharmacological Treatment of Bipolar Disorder

edited by

Shaohua Hu

submission deadline 20 Nov 2025 | 5 articles | Viewed by 32908 | Submission Open

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Diseases Affecting Urinary Tract

edited by

Priscila de Souza

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4260 | Submission Open

Keywords: natural products; plant extracts and isolated compounds; synthesized compounds; modified compounds; drug repositioning; kidney stone; urolithiasis; diuresis; urinary tract; urinary tract infection; cystitis; urethritis; nephritis; renal hypertension; diabetic nephropathy; nephrotoxicity; renal failure; urinary incontinence; overactive bladder; prostatitis; prostatic hyperplasia

(This special issue belongs to the Section Pharmacology)

Protein and Peptide-Based Drug Delivery

edited by Hoda M. Eltaher

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4130 | Submission Open

Keywords: proteolytic degradation; chemical stability; immunogenicity; oral bioavailability; scalability; off- target; effects; bioconjugation; peptide engineering; biodegradable polymers; regulatory and clinical considerations

(This special issue belongs to the Section Biopharmaceuticals)

Antiplatelet Therapy in Inflammatory Diseases

edited by

Patricia Pia Wadowski

submission deadline 20 Nov 2025 | Viewed by 352 | Submission Open

Keywords: atherosclerotic diseases; inflammatory diseases; antiplatelet therapy; platelet inhibition

(This special issue belongs to the Section Biopharmaceuticals)

Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 25 Nov 2025 | 8 articles | Viewed by 46571 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

Discovery of Novel Antidepressants and Anxiolytics

edited by James Oluwagbamigbe Fajemiroye and Gunnar P. H. Dietz

submission deadline 25 Nov 2025 | 7 articles | Viewed by 23097 | Submission Open

Keywords: biomarkers; depression; anxiety; anxiolytics; antidepressants; preclinical or clinical overview; experimental data; adverse effects; pharmacotherapy options; novel drugs

(This special issue belongs to the Section Pharmacology)

Multitargeted Compounds: A Promising Approach in Medicinal Chemistry

edited by Abdallah Hamze

submission deadline 25 Nov 2025 | 6 articles | Viewed by 18066 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 Nov 2025 | 5 articles | Viewed by 16666 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Peptide Synthesis and Drug Development: Exploring Progress and Potential

edited by

Othman Al Musaimi

, Da’san M.M. Jaradat and Vera D'Aloisio

submission deadline 25 Nov 2025 | 5 articles | Viewed by 12811 | Submission Open

Keywords: peptides; enzymatic degradation; drug discovery; formulation; draggability

(This special issue belongs to the Section Biopharmaceuticals)

Biosimilars Development Strategies

edited by

Sarfaraz K. Niazi

and Sesselja S. Ómarsdóttir

submission deadline 25 Nov 2025 | 4 articles | Viewed by 9455 | Submission Open

Keywords: biosimilars; generic medicines; drug development; biosimilar development

(This special issue belongs to the Section Medicinal Chemistry)

Artificial Intelligence-Assisted Drug Discovery

edited by Aldo Sena De Oliveira

submission deadline 25 Nov 2025 | 2 articles | Viewed by 8769 | Submission Open

Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova-Simkova

submission deadline 25 Nov 2025 | 4 articles | Viewed by 8277 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 25 Nov 2025 | 5 articles | Viewed by 6974 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

New Development in Pharmacotherapy of Kidney Diseases

edited by Chihchao Yang

submission deadline 25 Nov 2025 | 4 articles | Viewed by 6896 | Submission Open

Keywords: chronic kidney disease (CKD); acute kidney injury (AKI); pharmacotherapy; cardiovascular protection; kidney protection; bone health; endocrine function; gut health; metabolism; neuromuscular function; nutrition; symptom management; sodium-glucose cotransporter-2 (SGLT-2) inhibitors; glucagon-like peptide-1 (GLP-1) receptor agonists; non-steroidal mineralocorticoid receptor antagonists (MRA); endothelin receptor antagonists; anemia management; electrolyte abnormalities; dialysis; nephrotoxicity; drug interactions; uremic toxin; clinical trials; innovative therapies; protein-energy wasting; chronic kidney disease and bone mineral disease; inflammation; oxidation; diabetes; hypertension; obesity; hyperlipidemia; pruritus; osteoporosis; fracture; sarcopenia; protein-energy wasting

(This special issue belongs to the Section Pharmacology)

Nanotechnology in Biomedical Applications

edited by

Luciano Paulino Silva

submission deadline 25 Nov 2025 | 6 articles | Viewed by 6758 | Submission Open

Keywords: nanotechnology; nanobiotechnology; biomedical applications; drug delivery; nanobiosensors; targeted therapy; diagnostics; nanomaterials; therapeutics; theranostics

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Therapeutic Strategies for Alzheimer’s Disease Treatment

edited by

Melvin Hayden

submission deadline 25 Nov 2025 | 1 articles | Viewed by 4949 | Submission Open

Keywords: Sporadic; late-onset Alzheimer’ s disease (LOAD); neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 3159 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Nov 2025 | 3 articles | Viewed by 3105 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety

edited by

Cristina Sofia De Jesus Monteiro

and

Samuel Martins Silvestre

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2856 | Submission Open

Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management

(This special issue belongs to the Section Pharmacology)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2225 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2168 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

Pharmacology and Toxicology of Opioids, 2nd Edition

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1837 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

Pharmaceutical Approaches to Orofacial Pain and Chronic Pain Conditions

edited by

Takahiko Nagamine

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1677 | Submission Open

Keywords: chronic orofacial pain; pharmaceutical approach; myofascial orofacial pain; temporomandibular joint pain; neurovascular orofacial pain; idiopathic orofacial pain; burning mouth syndrome; persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; tricyclic antidepressants; serotonin reuptake inhibitors; anticonvulsants

(This special issue belongs to the Section Pharmacology)

Antimicrobial Therapies Affect the Microbial Ecosystems Within Our Body: The Urinary Microbiome and Urolithiasis

edited by

Loredana Sabina Cornelia Manolescu

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1462 | Submission Open

Keywords: antibiotics; antimicrobials; resistance; microbiome; urolithiasis; biofilms; infections; pathogens; pharmacotherapy; inflammation

(This special issue belongs to the Section Pharmacology)

Advances in Hydrazone Compounds with Anticancer Activity

edited by

Boryana Nikolova-Mladenova

and

Mariyana Atanasova

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1369 | Submission Open

Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity

(This special issue belongs to the Section Medicinal Chemistry)

Epithelial Plasticity and Therapy Resistance in Cancer

edited by Naisana Seyedasli

submission deadline 25 Nov 2025 | 1 articles | Viewed by 981 | Submission Open

Keywords: cancer stem cells; epithelial– mesenchymal transition; epithelial reprogramming; resistance; drug targets; resistance mechanisms; biomarker discovery

(This special issue belongs to the Section Pharmacology)

Dental Medication

edited by

Michelle Franz-Montan

and

Camila Batista Da Silva

submission deadline 25 Nov 2025 | 1 articles | Viewed by 848 | Submission Open

Keywords: dental medication; local anesthetics; controlled drug delivery; nanotechnology in dentistry; therapeutic biomaterials; smart drug delivery systems; digital health in dental pharmacology; dental materials

(This special issue belongs to the Section Pharmaceutical Technology)

New Findings in Pharmacogenomics of Neuropsychiatric Disorders

edited by

Alireza Tafazoli

and

Mandana Hasanzad

submission deadline 25 Nov 2025 | Viewed by 488 | Submission Open

Keywords: pharmacogenomics; genome informatics; advanced DNA-sequencing technologies; bioinformatics of pharmacogenomics; diagnostic approaches in the pharmacogenomics of neuropsychiatric disorders

(This special issue belongs to the Section Pharmacology)

The Development and Application of Broad-Spectrum Antiviral Drugs

edited by Chieh-Wen Lo

submission deadline 25 Nov 2025 | Viewed by 480 | Submission Open

Keywords: broad-spectrum antiviral; direct-acting antiviral; host-targeted antiviral; emerging viruses; pandemic preparedness

(This special issue belongs to the Section Medicinal Chemistry)

Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases

edited by

Edoardo V. Savarino

and Brigida Barberio

submission deadline 25 Nov 2025 | Viewed by 374 | Submission Open

Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics

(This special issue belongs to the Section Medicinal Chemistry)

Anticancer Compounds in Medicinal Plants—4th Edition

edited by

Paulo Santos

and

Lillian Barros

submission deadline 25 Nov 2025 | Viewed by 319 | Submission Open

Keywords: natural products; phytochemicals; cancer; secondary metabolites; medicinal plants

(This special issue belongs to the Section Natural Products)

Application of Nanotechnology in Drug Delivery

edited by

Camila Batista Da Silva

and

Michelle Franz-Montan

submission deadline 25 Nov 2025 | 1 articles | Viewed by 303 | Submission Open

Keywords: drug discovery; drug combinations; nanotechnology; drug liberation

(This special issue belongs to the Section Pharmaceutical Technology)

Metal Complexes in Medicinal Chemistry: From Coordination Chemistry to Pharmaceutical Applications

edited by

Laura Rodriguez-Silva

and Cristina Núñez González

submission deadline 25 Nov 2025 | Viewed by 177 | Submission Open

Keywords: medicinal inorganic chemistry; metallodrugs; coordination compounds; bioinorganic chemistry; anticancer agents; antimicrobial agents; therapeutic applications; diagnostic applications; bioactive metal complexes; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development

edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes

submission deadline 25 Nov 2025 | Viewed by 170 | Submission Open

Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization

(This special issue belongs to the Section Medicinal Chemistry)

Small Molecules to Fight Cancer and Neurodegenerative Diseases

edited by

Daniela Catarzi

Vittoria Colotta

and

Flavia Varano

submission deadline 25 Nov 2025 | Viewed by 139 | Submission Open

Keywords: small molecules; cancer; neurodegenerative diseases; receptor ligands; enzyme modulators; targeted drugs; multitarget agents; PROTACs; immunomodulators; natural products; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Targeting Bacterial Metabolism with Natural and Synthetic Inhibitors

edited by

Mihaela Ileana Ionescu

Cristina Nastasă

and

Ovidiu Oniga

submission deadline 25 Nov 2025 | Viewed by 117 | Submission Open

Keywords: bacterial metabolism; protein kinases; therapeutic strategy; clinical studies; natural inhibitors; enzymatic activity; drug design; structural studies

(This special issue belongs to the Section Medicinal Chemistry)

Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology

edited by

Marvin Antonio Soriano-Ursúa

and

Andrei Biță

submission deadline 28 Nov 2025 | 5 articles | Viewed by 9242 | Submission Open

Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization

(This special issue belongs to the Section Medicinal Chemistry)

Medicinal Plants: Current Insights into Their Biological Activities and Integration with Micro- or Nanotechnologies

edited by

Jorge L. Mejía Méndez

Gildardo Sanchez-Ante

and

Edgar R. López-Mena

submission deadline 28 Nov 2025 | 2 articles | Viewed by 4215 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive nanomaterials; inorganic materials; organic materials; drug delivery systems

Next-Generation Targeted Therapy: vNARs as Drug Carriers and Intracellular Neutralizing Agents

edited by

Tanya Camacho-Villegas

and

Mirna Burciaga-Flores

submission deadline 28 Nov 2025 | Viewed by 144 | Submission Open

Keywords: vNAR; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single-domain antibody

(This special issue belongs to the Section Pharmacology)

New Insights of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Biomedical Applications

edited by

Afif Nakhleh

, Bshara Mansour and Naim Shehadeh

submission deadline 30 Nov 2025 | 3 articles | Viewed by 11925 | Submission Open

Keywords: SGLT2 Inhibitors; cardiovascular protection; renal health; metabolic benefits

(This special issue belongs to the Section Pharmacology)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2833 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

Pharmacological Strategies to Modulate Symptoms in Autism Spectrum Disorders (ASD)

edited by

Jaime Mella Raipan

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2687 | Submission Open

Keywords: pharmacological treatment of ASD; neurodevelopmental disorders; molecular modeling and ASD; drug discovery for autism; repurposing drugs for ASD; 5-HT receptors; GABAergic system; TRPC6; mGluR5

(This special issue belongs to the Section Pharmacology)

Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment

edited by

Zlatina Gospodinova

and

Michael Danilenko

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1085 | Submission Open

Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies

(This special issue belongs to the Section Natural Products)

Comprehensive Strategies in Cancer Immunotherapy

edited by Yee Peng Phoon

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1042 | Submission Open

Keywords: immunotherapy; CAR-T; TIL therapy; predictive biomarker; neoadjuvant; cytokine therapy; bispecific antibodies; personalized treatment; combination therapies; tumor microenvironment; immune modulation; interaction and mechanism

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Metabolic Diseases Prevention and Intervention

edited by