Special Issue "Modulation of Pathogenicity and Virulence by Molecules and Nanostructures"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (31 July 2016)
Dr. Alexandru Mihai Grumezescu
Department of Science and Engineereing of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, RO-011061, Bucharest, Romania
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Interests: synthesis and characterization of nanobiomaterials; pharmaceutical nanotechnology; drug targeting; drug delivery; anti-biofilm surfaces; nanomodified surfaces; thin films; natural products
Because of the huge medical, social, industrial and economic impact, antimicrobial resistance phenomenon is currently considered an aspect of worldwide interest. Alternative therapeutic approaches are intensively studied for the design of efficient antimicrobials in order to reduce morbidity and mortality associated with the emergence of resistant pathogens. Currently, strategies aiming to modulate pathogenicity and virulence of microorganisms are of a particular interest, since it is considered that they could reduce the rate of antibiotic resistance and limit the spread of difficult to treat infections. However, the scientific progress on this field is still limited mainly due to the difficulty to find and design efficient molecules and structures that could interact efficiently with the highly complicated molecular signalling pathways that control virulence. Many molecular signalling systems are yet unknown and their study progresses slowly due to their complexity and molecular and sub-molecular scale processes that are difficult to control. In this context, the science of nanometer size materials could provide the appropriate tools both to investigate alternative methods to modulate pathogenicity and virulence, but also to improve the investigation methods for the complex microbial signalling in order to facilitate the identification of new therapeutic targets. Moreover, nanostructures are currently utilized for multiple biomedical approaches that aim to develop novel antimicrobial therapies, significant progress being made on the field of drug delivery and targeted release of antimicrobials. Nanotechnology could also be useful for the stabilization and efficiency improvement of recently identified molecules able to interfere with microbial virulence and behaviour.
This Special Issue aims to bring together the most recent and interesting advances on the field of molecular microbiology and the impact of natural (i.e., microbial and host-related) molecules in the control of pathogenicity and virulence, and to highlight the impact of nanostructures in the development of novel and efficient antimicrobial approaches by exploitation of different molecular and nanosized structures.
Dr. Alexandru Mihai Grumezescu
Dr. Alina Maria Holban
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Molecular therapy
- Microbial signaling
- Host-pathogens interactions
- Virulence modulation
- Anti-biofilm strategies
- Natural antimicrobials
- Functionalized nanomaterials
- Antimicrobial drug delivery systems
- Nanosystems for infection control
- Nanosized materials in molecular signaling