Special Issue "Novel Materials for Antimicrobial Application"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 1 August 2020.

Special Issue Editor

Special Issue Information

Dear Colleagues,

Infectious diseases still represent one of the leading cause of mortality and morbidity worldwide. Despite the huge effort in developing new antibiotics, the antimicrobial resistance phenomenon is constantly emerging, drastically limiting the available therapeutic options. Alternative options are intensively investigated to reduce the severe effects of increasingly inefficient antibiotics and in this context materials science steps forward with innovative and highly efficient solutions.

The aim of this special issue is to bring together newest progress made on the design and biomedical applications of new materials with antimicrobial properties. Among these, a special attention is paid to nanostructured materials, which could act as efficient drug delivery systems and would promote the antimicrobial effects of natural and synthetic antimicrobial agents. Also, materials which could modulate microbial virulence and social behaviours, such as attachment and biofilm formation, represent a new desirate on the emerging field of antimicrobial materials. New materials are also expected to be utilized in the design of medical devices, to produce tailored surfaces for medical, industrial (i.e. food and beverage, textile etc) and ecological purposes, which are able to avoid contamination and modulate microbial development. Research and review papers containing new findings and perspectives on this intringuing field are welcomed to be considered for this special issue.

Dr. Alina Maria Holban
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial materials
  • biofilm modulation
  • bioactive nanomaterials
  • antimicrobial surfaces, coatings and devices
  • contamination control
  • alternative antimicrobials

Published Papers (4 papers)

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Research

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Open AccessArticle
Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils
Materials 2020, 13(7), 1618; https://doi.org/10.3390/ma13071618 - 01 Apr 2020
Abstract
This research aimed to obtain biocompatible and antimicrobial nanofibres based on concentrated collagen hydrolysate loaded with thyme or oregano essential oils as a natural alternative to synthesis products. The essential oils were successfully incorporated using electrospinning process into collagen resulting nanofibres with diameter [...] Read more.
This research aimed to obtain biocompatible and antimicrobial nanofibres based on concentrated collagen hydrolysate loaded with thyme or oregano essential oils as a natural alternative to synthesis products. The essential oils were successfully incorporated using electrospinning process into collagen resulting nanofibres with diameter from 471 nm to 580 nm and porous structure. The presence of essential oils in collagen nanofibre mats was confirmed by Attenuated Total Reflectance -Fourier Transform Infrared Spectroscopy (ATR-FTIR), Ultraviolet–visible spectroscopy (UV–VIS) and antimicrobial activity. Scanning Electron Microscopy with Energy Dispersive Spectroscopy analyses allowed evaluating the morphology and constituent elements of the nanofibre networks. Microbiological tests performed against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans showed that the presence of essential oils supplemented the new collagen nanofibres with antimicrobial properties. The biocompatibility of collagen and collagen with essential oils was assessed by in vitro cultivation with NCTC clone 929 of fibroblastic cells and cell viability measurement. The results showed that the collagen and thyme or oregano oil composites have no cytotoxicity up to concentrations of 1000 μg·mL−1 and 500 μg mL−1, respectively. Optimization of electrospinning parameters has led to the obtaining of new collagen electrospun nanofibre mats loaded with essential oils with potential use for wound dressings, tissue engineering or protective clothing. Full article
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
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Open AccessFeature PaperArticle
Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications
Materials 2019, 12(16), 2521; https://doi.org/10.3390/ma12162521 - 08 Aug 2019
Abstract
We report on the synthesis and evaluation of biopolymeric spheres of poly(lactide-co-glycolide) containing different amounts of magnetite nanoparticles and Ibuprofen (PLGA-Fe3O4-IBUP), but also chitosan (PLGA-CS-Fe3O4-IBUP), to be considered as drug delivery systems. Besides morphological, structural, [...] Read more.
We report on the synthesis and evaluation of biopolymeric spheres of poly(lactide-co-glycolide) containing different amounts of magnetite nanoparticles and Ibuprofen (PLGA-Fe3O4-IBUP), but also chitosan (PLGA-CS-Fe3O4-IBUP), to be considered as drug delivery systems. Besides morphological, structural, and compositional characterizations, the PLGA-Fe3O4-IBUP composite microspheres were subjected to drug release studies, performed both under biomimetically-simulated dynamic conditions and under external radiofrequency magnetic fields. The experimental data resulted by performing the drug release studies evidenced that PLGA-Fe3O4-IBUP microspheres with the lowest contents of Fe3O4 nanoparticles are optimal candidates for triggered drug release under external stimulation related to hyperthermia effect. The as-selected microspheres and their chitosan-containing counterparts were biologically assessed on macrophage cultures, being evaluated as biocompatible and bioactive materials that are able to promote cellular adhesion and proliferation. The composite biopolymeric spheres resulted in inhibited microbial growth and biofilm formation, as assessed against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans microbial strains. Significantly improved antimicrobial effects were reported in the case of chitosan-containing biomaterials, regardless of the microorganisms’ type. The nanostructured composite biopolymeric spheres evidenced proper characteristics as prolonged and controlled drug release platforms for multipurpose biomedical applications. Full article
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
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Open AccessFeature PaperArticle
Antimicrobial Wound Dressings as Potential Materials for Skin Tissue Regeneration
Materials 2019, 12(11), 1859; https://doi.org/10.3390/ma12111859 - 08 Jun 2019
Cited by 5
Abstract
The most important properties of performant wound dressings are biocompatibility, the ability to retain large amount of exudate and to avoid complications related with persistent infection which could lead to delayed wound healing. This research aimed to obtain and characterize a new type [...] Read more.
The most important properties of performant wound dressings are biocompatibility, the ability to retain large amount of exudate and to avoid complications related with persistent infection which could lead to delayed wound healing. This research aimed to obtain and characterize a new type of antimicrobial dressings, based on zinc oxide/sodium alginate/polyvinyl alcohol (PVA). Zinc oxide nanostructures, obtained with different morphology and grain size by hydrothermal and polyol methods, are used as antimicrobial agents along with sodium alginate, which is used to improve the biocompatibility of the dressing. The nanofiber dressing was obtained through the electrospinning method. Characterization techniques such as X-ray diffraction (XRD) and scanning electron microscopy (SEM) were performed to determine the structural and morphological properties of the obtained powders and composite fibers. Their antimicrobial activity was tested against Gram negative Escherichia coli (E. coli), Gram positive Staphylococcus aureus (S. aureus) bacteria and Candida albicans (C. albicans) yeast strains. The in vitro biocompatibility of the obtained composites was tested on human diploid cells. The obtained results suggest that the composite fibers based on zinc oxide and alginate are suitable for antimicrobial protection, are not toxic and may be useful for skin tissue regeneration if applied as a dressing. Full article
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
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Review

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Open AccessReview
Nanomaterials for Wound Healing and Infection Control
Materials 2019, 12(13), 2176; https://doi.org/10.3390/ma12132176 - 06 Jul 2019
Cited by 11
Abstract
Wound healing has been intensely studied in order to develop an “ideal” technique that achieves expeditious recovery and reduces scarring to the minimum, thus ensuring function preservation. The classic approach to wound management is represented by topical treatments, such as antibacterial or colloidal [...] Read more.
Wound healing has been intensely studied in order to develop an “ideal” technique that achieves expeditious recovery and reduces scarring to the minimum, thus ensuring function preservation. The classic approach to wound management is represented by topical treatments, such as antibacterial or colloidal agents, in order to prevent infection and promote a proper wound-healing process. Nanotechnology studies submicroscopic particles (maximum diameter of 100 nm), as well as correlated phenomena. Metal nanoparticles (e.g., silver, gold, zinc) are increasingly being used in dermatology, due to their beneficial effect on accelerating wound healing, as well as treating and preventing bacterial infections. Other benefits include: ease of use, less frequent dressing changes and a constantly moist wound environment. This review highlights recent findings regarding nanoparticle application in wound management. Full article
(This article belongs to the Special Issue Novel Materials for Antimicrobial Application)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Alexandru Mihai Grumezescu
Affiliation: Politehnica University of Bucharest, Romania

Author: Ficai Anton
Affiliation:
Politehnica University of Bucharest, Romania

Author: Bogdan Stefan Vasile
Affiliation: Politehnica University of Bucharest, Romania

Author:Alina Maria Holban
Affiliation:
University of Bucharest, Romania

Author: Mariana Carmen Chifiriuc
Affiliation:
University of Bucharest, Romania

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