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Nutrients
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Vitamin, Mineral, and Diet Supplementation for Women Health
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Vitamin, Mineral, and Diet Supplementation for Women Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 23074

Special Issue Editors

Prof. Dr. Kai Joachim Bühling

E-Mail Website
Guest Editor
Univ Klinikum Hamburg Eppendorf, Hormone Consultation, Klin & Poliklin Gynakol, Hamburg, Germany
Interests: obstetrics; gynecology; endocrinology; pregnancies; fertility; hormone
Dr. Elena Laakmann

E-Mail Website
Guest Editor
Department of Gynecology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
Interests: obstetrics; gynecology; endocrinology; pregnancies; fertility; hormone

Special Issue Information

Dear Colleagues,

Substitution of vitamins and minerals is widespread in a preventive and therapeutic setting, as well as in the field of complementary medicine. Several substances have been discussed for the prevention of cardiovascular diseases as well as cancer. Vitamin D, selenium, vitamin a, omega-3-fatty acid, as well as lycopene are just some of them. Additionally, ginkgo biloba is known as a substance not only for the prevention of cognitive disorders but also for cardiovascular diseases.

In the field of gynecological oncology, for example, in the treatment of breast and ovarian cancer as well as uterine cancer, a big interest of patients and physicians concerning the supplementation of vitamins and minerals in addition to the standard oncological therapy can be recorded. The substitution of selenium and vitamin D is especially widespread.

Despite the wide use, the database for the substitution of vitamins and minerals is often rare.

The aim of this Special Issue is to provide an overview of the evidence-based use of vitamins and minerals in the clinical fields mentioned above. Furthermore, new findings concerning the mechanisms of action of the micronutrients are of relevant interest.

Therefore, we invite clinicians and basic researchers to share their research results about supplementation of vitamins and minerals with the aim of prevention of diseases in women, as well as in the field of complementary medicine in addition to standard cancer therapy.

The original research articles, as well as meta-analyses, are welcome.

Prof. Dr. Kai Joachim Bühling
Dr. Elena Laakmann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • women disease
  • cancer
  • vitamins
  • minerals
  • supplementation
  • preventive
  • complementary medicine

Published Papers (7 papers)

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Research

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15 pages, 1853 KiB  
Article
Association of Gut Microbiota Enterotypes with Blood Trace Elements in Women with Infertility
by Xinrui Yao, Na Zuo, Wenzheng Guan, Lingjie Fu, Shuyi Jiang, Jiao Jiao and Xiuxia Wang
Nutrients 2022, 14(15), 3195; https://doi.org/10.3390/nu14153195 - 4 Aug 2022
Cited by 3 | Viewed by 2365
Abstract
Infertility is defined as failure to achieve pregnancy within 12 months of unprotected intercourse in women. Trace elements, a kind of micronutrient that is very important to female reproductive function, are affected by intestinal absorption, which is regulated by gut microbiota. Enterotype is [...] Read more.
Infertility is defined as failure to achieve pregnancy within 12 months of unprotected intercourse in women. Trace elements, a kind of micronutrient that is very important to female reproductive function, are affected by intestinal absorption, which is regulated by gut microbiota. Enterotype is the classification of an intestinal microbiome based on its characteristics. Whether or not Prevotella-enterotype and Bacteroides-enterotype are associated with blood trace elements among infertile women remains unclear. The study aimed to explore the relationship between five main whole blood trace elements and these two enterotypes in women with infertility. This retrospective cross-sectional study recruited 651 Chinese women. Whole blood copper, zinc, calcium, magnesium, and iron levels were measured. Quantitative real-time PCR was performed on all fecal samples. Patients were categorized according to whole blood trace elements (low levels group, <5th percentile; normal levels group, 5th‒95th percentile; high levels group, >95th percentile). There were no significant differences in trace elements between the two enterotypes within the control population, while in infertile participants, copper (P = 0.033), zinc (P < 0.001), magnesium (P < 0.001), and iron (P < 0.001) in Prevotella-enterotype was significantly lower than in Bacteroides-enterotype. The Chi-square test showed that only the iron group had a significant difference in the two enterotypes (P = 0.001). Among infertile patients, Prevotella-enterotype (Log(P/B) > −0.27) predicted the low levels of whole blood iron in the obesity population (AUC = 0.894; P = 0.042). For the high levels of iron, Bacteroides-enterotype (Log(P/B) <−2.76) had a predictive power in the lean/normal group (AUC = 0.648; P = 0.041) and Log(P/B) <−3.99 in the overweight group (AUC = 0.863; P = 0.013). We can infer that these two enterotypes may have an effect on the iron metabolism in patients with infertility, highlighting the importance of further research into the interaction between enterotypes and trace elements in reproductive function. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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12 pages, 541 KiB  
Article
CYP7A1, NPC1L1, ABCB1, and CD36 Polymorphisms Associated with Coenzyme Q10 Availability Affect the Subjective Quality of Life Score (SF-36) after Long-Term CoQ10 Supplementation in Women
by Michiyo Takahashi, Tetsu Kinoshita, Koutatsu Maruyama and Toshikazu Suzuki
Nutrients 2022, 14(13), 2579; https://doi.org/10.3390/nu14132579 - 22 Jun 2022
Cited by 3 | Viewed by 1890
Abstract
The single nucleotide polymorphisms (SNPs) rs3808607, rs2072183, rs2032582, and rs1761667 are associated with coenzyme Q10 (CoQ10) bioavailability in women after long-term CoQ10 supplementation. However, the beneficial aspects of the association between these SNPs and CoQ10 supplementation remain unknown. [...] Read more.
The single nucleotide polymorphisms (SNPs) rs3808607, rs2072183, rs2032582, and rs1761667 are associated with coenzyme Q10 (CoQ10) bioavailability in women after long-term CoQ10 supplementation. However, the beneficial aspects of the association between these SNPs and CoQ10 supplementation remain unknown. We investigated their relationship using the subjective quality of life score SF-36 by reanalyzing previous data from 92 study participants who were receiving ubiquinol (a reduced form of CoQ10) supplementation for 1 year. Two-way repeated-measures analysis of variance revealed a significant interaction between rs1761667 and the SF-36 scores of role physical (p = 0.016) and mental health (p = 0.017) in women. Subgrouping of participants based on the above four SNPs revealed significant interactions between these SNPs and the SF-36 scores of general health (p = 0.045), role emotional (p = 0.008), and mental health (p = 0.019) and increased serum CoQ10 levels (p = 0.008), suggesting that the benefits of CoQ10 supplementation, especially in terms of psychological parameters, are genotype-dependent in women. However, significant interactions were not observed in men. Therefore, inclusion of SNP subgrouping information in clinical trials of CoQ10 supplementation may provide conclusive evidence supporting other beneficial health effects exerted by the association between these SNPs and CoQ10 on women. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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Review

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10 pages, 1274 KiB  
Review
Role of Vitamin K in Selected Malignant Neoplasms in Women
by Anna Markowska, Michał Antoszczak, Janina Markowska and Adam Huczyński
Nutrients 2022, 14(16), 3401; https://doi.org/10.3390/nu14163401 - 18 Aug 2022
Cited by 13 | Viewed by 3397
Abstract
The main function of vitamin K in the human organism is its activity in the blood clotting cascade. Epidemiological studies suggest that reduced intake of vitamin K may contribute to an increased risk of geriatric diseases such as atherosclerosis, dementia, osteoporosis, and osteoarthritis. [...] Read more.
The main function of vitamin K in the human organism is its activity in the blood clotting cascade. Epidemiological studies suggest that reduced intake of vitamin K may contribute to an increased risk of geriatric diseases such as atherosclerosis, dementia, osteoporosis, and osteoarthritis. A growing number of studies also indicate that vitamin K may be involved not only in preventing the development of certain cancers but it may also support classical cancer chemotherapy. This review article summarizes the results of studies on the anticancer effects of vitamin K on selected female malignancies, i.e., breast, cervical, and ovarian cancer, published over the past 20 years. The promising effects of vitamin K on cancer cells observed so far indicate its great potential, but also the need for expansion of our knowledge in this area by conducting extensive research, including clinical trials. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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19 pages, 4738 KiB  
Review
Biomarkers Regulated by Lipid-Soluble Vitamins in Glioblastoma
by Dina El-Rabie Osman, Brandon Wee Siang Phon, Muhamad Noor Alfarizal Kamarudin, Stephen Navendran Ponnampalam, Ammu Kutty Radhakrishnan and Saatheeyavaane Bhuvanendran
Nutrients 2022, 14(14), 2873; https://doi.org/10.3390/nu14142873 - 13 Jul 2022
Cited by 1 | Viewed by 2219
Abstract
Glioblastoma (GBM), a highly lethal form of adult malignant gliomas with little clinical advancement, raises the need for alternative therapeutic approaches. Lipid-soluble vitamins have gained attention in malignant brain tumors owing to their pleiotropic properties and their anti-cancer potential have been reported in [...] Read more.
Glioblastoma (GBM), a highly lethal form of adult malignant gliomas with little clinical advancement, raises the need for alternative therapeutic approaches. Lipid-soluble vitamins have gained attention in malignant brain tumors owing to their pleiotropic properties and their anti-cancer potential have been reported in a number of human GBM cell lines. The aim of this paper is to systematically review and describe the roles of various biomarkers regulated by lipid-soluble vitamins, such as vitamins A, D, E, and K, in the pathophysiology of GBM. Briefly, research articles published between 2005 and 2021 were systematically searched and selected from five databases (Scopus, PubMed, Ovid MEDLINE, EMBASE via Ovid, and Web of Science) based on the study’s inclusion and exclusion criteria. In addition, a number of hand-searched research articles identified from Google Scholar were also included for the analysis. A total of 40 differentially expressed biomarkers were identified from the 19 eligible studies. The results from the analysis suggest that retinoids activate cell differentiation and suppress the biomarkers responsible for stemness in human GBM cells. Vitamin D appears to preferentially modulate several cell cycle biomarkers, while vitamin E derivatives seem to predominantly modulate biomarkers related to apoptosis. However, vitamin K1 did not appear to induce any significant changes to the Raf/MEK/ERK signaling or apoptotic pathways in human GBM cell lines. From the systematic analysis, 12 biomarkers were identified that may be of interest for further studies, as these were modulated by one or two of these lipid-soluble vitamins. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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17 pages, 1031 KiB  
Review
Role of Vitamin C in Selected Malignant Neoplasms in Women
by Anna Markowska, Michał Antoszczak, Janina Markowska and Adam Huczyński
Nutrients 2022, 14(4), 882; https://doi.org/10.3390/nu14040882 - 19 Feb 2022
Cited by 8 | Viewed by 3874
Abstract
Since the first reports describing the anti-cancer properties of vitamin C published several decades ago, its actual effectiveness in fighting cancer has been under investigation and widely discussed. Some scientific reports indicate that vitamin C in high concentrations can contribute to effective and [...] Read more.
Since the first reports describing the anti-cancer properties of vitamin C published several decades ago, its actual effectiveness in fighting cancer has been under investigation and widely discussed. Some scientific reports indicate that vitamin C in high concentrations can contribute to effective and selective destruction of cancer cells. Furthermore, preclinical and clinical studies have shown that relatively high doses of vitamin C administered intravenously in ‘pharmacological concentrations’ may not only be well-tolerated, but significantly improve patients’ quality of life. This seems to be particularly important, especially for terminal cancer patients. However, the relatively high frequency of vitamin C use by cancer patients means that the potential clinical benefits may not be obvious. For this reason, in this review article, we focus on the articles published mainly in the last two decades, describing possible beneficial effects of vitamin C in preventing and treating selected malignant neoplasms in women, including breast, cervical, endometrial, and ovarian cancer. According to the reviewed studies, vitamin C use may contribute to an improvement of the overall quality of life of patients, among others, by reducing chemotherapy-related side effects. Nevertheless, new clinical trials are needed to collect stronger evidence of the role of this nutrient in supportive cancer treatment. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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Other

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35 pages, 1107 KiB  
Systematic Review
Inflammatory Response in Oral Biofilm during Pregnancy: A Systematic Review
by Berit Lieske, Nataliya Makarova, Bettina Jagemann, Carolin Walther, Merle Ebinghaus, Birgit-Christiane Zyriax and Ghazal Aarabi
Nutrients 2022, 14(22), 4894; https://doi.org/10.3390/nu14224894 - 19 Nov 2022
Cited by 3 | Viewed by 2466
Abstract
Understanding the inflammatory response in oral biofilm during pregnancy and its association with oral and maternal health is essential for identifying biomarker patterns that may serve as markers of pregnancy-related complications. We aimed to conduct a systematic review of the available literature to [...] Read more.
Understanding the inflammatory response in oral biofilm during pregnancy and its association with oral and maternal health is essential for identifying biomarker patterns that may serve as markers of pregnancy-related complications. We aimed to conduct a systematic review of the available literature to assess: (1) inflammatory responses in oral biofilm during pregnancy, (2) the association between inflammatory responses in oral biofilm during pregnancy and maternal, oral or systemic conditions, (3) changes in the response of inflammatory biomarkers found in the oral biofilm during different pregnancy stages, and (4) the value of other risk factors such as nutrition and lifestyle. PubMed, Web of Science and Cochrane Library were systematically searched from inception until April 2022. From 5441 records, 39 studies were included for qualitative assessment. The oral biofilm in pregnant women was associated with increased inflammatory biomarkers when compared to non-pregnant women. Levels of inflammatory biomarkers in the oral biofilm were found to be highest in pregnant women with systemic conditions. Increased inflammatory biomarkers in the oral biofilm were also associated with worse oral health outcomes. Given the importance of nutrition and lifestyle for pregnancy and oral health outcomes and the fact that these factors were largely excluded in the included studies, future research should consider a holistic view of the mother during pregnancy to capture physiological, hormonal, immunologic, and metabolic changes in the context of inflammatory responses. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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17 pages, 2638 KiB  
Systematic Review
Effectiveness of Dietary Interventions to Treat Iron-Deficiency Anemia in Women: A Systematic Review of Randomized Controlled Trials
by Dominika Skolmowska, Dominika Głąbska, Aleksandra Kołota and Dominika Guzek
Nutrients 2022, 14(13), 2724; https://doi.org/10.3390/nu14132724 - 30 Jun 2022
Cited by 9 | Viewed by 5921
Abstract
Iron-deficiency anemia is the most frequent nutritional deficiency, with women of reproductive age being particularly at risk of its development. The aim of the systematic review was to assess the effectiveness of dietary interventions to treat iron-deficiency anemia in women based on the [...] Read more.
Iron-deficiency anemia is the most frequent nutritional deficiency, with women of reproductive age being particularly at risk of its development. The aim of the systematic review was to assess the effectiveness of dietary interventions to treat iron-deficiency anemia in women based on the randomized controlled trials. The systematic review was conducted according to the PRISMA guidelines and registered in the PROSPERO database (CRD42021261235). The searching procedure was based on PubMed and Web of Science databases, while it covered records published until June 2021. It included all randomized controlled trials assessing effectiveness of various dietary interventions on treatment of iron-deficiency anemia in women of childbearing age. The total number of 7825 records were screened, while 14 of them were finally included in the systematic review. The studies were screened, included, and reported, and the risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials by two independent researchers. The included studies compared the effectiveness of various dietary interventions with supplementation, placebo, control, or any other dietary intervention, while the assessed dietary interventions were based either on increasing iron supply and/or on increasing its absorption (by increasing vitamin C or vitamin D or decreasing phytate intake). The duration of applied intervention was diversified from 3 months or less, through 4 or 5 months, to half of a year or more. Among the assessed biochemical measures, the following were analyzed in majority of studies: hemoglobin, ferritin, transferrin receptor, hematocrit, and transferrin. The majority of included studies supported the influence of dietary interventions on the treatment of iron-deficiency anemia, as the applied dietary intervention was not effective in only three studies. The majority of included studies were assessed as characterized by medium risk of bias, while the overall risk was high for only four studies, which resulted from the randomization process, deviations from the intended interventions, and selection of the reported result. The majority of included studies were conducted for increasing iron supply and/or increasing vitamin C supply; however, only for the interventions including increasing iron supply and simultaneously increasing its absorption by vitamin C supply were all results confirmed effective. Vitamin D also seems to be an effective dietary treatment, but further studies are necessary to confirm the observations. Considering this fact, dietary interventions recommended for anemic female patients should include increased intake of iron and vitamin C. Full article
(This article belongs to the Special Issue Vitamin, Mineral, and Diet Supplementation for Women Health)
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