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Special Issue "Vitamin A Update 2016"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (31 October 2016).
The requirement for proper vitamin A nutrition throughout the human life cycle is well established. Most of the functions of vitamin A (retinol) are attributable to its active form, retinoic acid (RA) and RA-linked gene transcription pathways regulating a multitude of cellular processes. In this Special Issue on vitamin A, the focus will be on topics in vitamin A area that have not been recently addressed, as well as on some recent discoveries regarding vitamin A metabolism and function. Among the topics covered will be the determination of vitamin A status, which is very important for providing proper nutritional guidelines, as well as for addressing health issues in world populations where vitamin A inadequacy still exists. Reliable methodology is crucial and particularly critical during gestation, so that adequate vitamin A supplementation can be implemented, reliable epidemiological studies conducted and educational approaches planned. Another review in this Special Issue will update the generation of vitamin A from its plant source pro-vitamins and will also address recent experimental findings regarding the vitamin A/beta-carotene and lipid interactions, pointing out some health-related concerns. Recent advances in metabolism and function of retinol and RA during vertebrate embryonic development will be the topic of another review, highlighting the identification of the crucial enzyme in the biogeneration of RA. This discovery has not only provided the missing regulatory link in the metabolic pathway to the active form of vitamin A, but has also opened up new avenues to study human birth defects that might be linked to errors in RA signaling. The important function of RA in the regulation of the immune system will be another topic addressed in this Special Issue. While the immune system in humans develops during gestation, hematopoiesis or the formation of blood, i.e., blood cells starts in the early embryo; these hematopoietic stem cells form new lineages during development, then expand to bone morrow where they remain after birth and during adulthood. This topic will also be covered in the Special Issue, as RA is one of the many signaling factors regulating hematopoiesis.
The Editors of Nutrients extend an invitation to scientists to submit original research or reviews on any of the above topics for this Special Issue on vitamin A.
Dr. Maija H. Zile
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Vitamin A, retinol
- Retinoic acid (RA), vitamin A active form at gene level
- Carotenoids, beta-carotene, provitamins A
- Vitamin A biosynthesis
- Assessment of vitamin A status
- Interventions to prevent vitamin A deficiency in populations at risk
- Vitamin A deficiency and infectious diseases in populations at risk
- RA and the immune system
- RA regulation of hematopoiesis
- Enzymes in RA biosynthesis
- Birth defects linked to errors in retinoic acid signaling