Special Issue "Nutrition and Metabolic (Non-alcoholic) Fatty Liver Disease (NAFLD)"
Deadline for manuscript submissions: closed (31 August 2020).
Interests: 1. Developmental programming of diabetes and obesity from mother to infant in Human and Non-Human Primates.
2. The Microbiome role in Innate Immunity and Non-alcoholic Fatty Liver Disease (NAFLD).
3. Metabolic/genomic determinants of Umbilical-cord derived Mesenchymal Stem Cell fate in Infants of Obese Mothers. 4. Nutritional intervention and epigenetic signatures in mothers and their infants in the developing world.
NAFLD is becoming an epidemic both in absolute and relative terms due to increasing prevalence of obesity and type 2 diabetes and the successful treatment of virus-induced liver diseases. As currently no drugs are approved for NAFLD, lifestyle modification with the main focus on diet remains key for its treatment. The overarching aim would be to illustrate the role of nutrients for NAFLD to allow for a conclusion on the optimized prevention and treatment by nutrients, and also to identify the obvious gap of knowledge as of today. Thus, the target readership is broad, from translational researchers, nutrition/obesity specialists, endocrinologists/diabetologists to hepatologists.
Such a comprehensive analysis of the role of nutrients for NAFLD requires discussion of the following:
- The epidemiological link between nutrients and NAFLD (systematic review)
- Description of the impact on liver metabolism and damage using different model organisms
- The role of macronutrients in the development and progression of NAFLD (fat, protein, carbohydrates)
- The specific relevance of fructose for fatty liver disease
- Clinical trials comparing low caloric vs specific nutrient-modified diets regarding liver-specific endpoints
Finally, one may also wish to compare the role of alcohol intake vs. overnutrition.
Prof. Dr. Jed Friedman
Manuscript Submission Information
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- energy metabolism