Diet, the Exposome, and Immunity: Microbiota and Beyond

Dear Colleagues,

The interplay between diet, environmental exposures, and immunity is increasingly recognized as a critical factor influencing health and disease. The gastrointestinal microbiota mediates many of these effects, serving as a dynamic interface between host and environment. Emerging evidence highlights that not only nutritional factors but also broader exposomic influences—such as pollutants, lifestyle, and stress—modulate immune function through microbial and metabolic pathways.

This Special Issue invites original research and reviews exploring the complex relationships among diet, the exposome, and immune responses, with particular attention to the role of gut microbiota and related mechanisms. We welcome studies addressing the dietary components, essential nutrients, microbiota-derived metabolites, and environmental determinants that influence immune function.

We are particularly interested in work that examines these interactions across the lifespan, including early-life exposures, developmental windows of vulnerability, and aging-related immune changes. Submissions may span mechanistic, clinical, epidemiological, or translational approaches that contribute to advancing our understanding of the microbiota–nutrition–immunity axis in diverse contexts.

Dr. Akihito Harusato
Dr. Tingchao He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.