Special Issue "Dietary Restriction and Lifespan"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Macronutrients and Human Health".

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editor

Prof. Dr. Thomas Roeder
E-Mail Website1 Website2
Guest Editor
Department of Molecular Physiology, Institute of Zoology, Kiel University, Kiel, Germany
Interests: Metabolic disorder; Dietary restriction; Disease model; Lifespan; Lung diseases; Microbiome

Special Issue Information

Dear Colleagues,

Dietary restriction (DR) is one of the few natural interventions that can lead to a longer and more healthy life. DR is an umbrella term for various forms of nutritional intervention, including caloric reduction, the reduction of macronutrients, and the temporal limitation of food intake. In this Special Issue of Nutrients, particular attention will be paid to studies using these different forms of DR to extend the life or health span. A main focus of this Special Issue of Nutrients will be on human studies, but studies employing cell culture systems or informative animal models are also welcome. Furthermore, mechanistic studies addressing those signaling pathways and effector systems that are of central importance to transducing DR into a longer life or those employing potential DR mimetics will also be considered.

Prof. Dr. Thomas Roeder
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary restriction
  • caloric restriction
  • time-restricted food intake
  • recurrent diet
  • protein restriction
  • starvation-mimicking diet
  • mTOR signaling
  • insulin signaling
  • sirtuins

Published Papers (1 paper)

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Research

Open AccessArticle
A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in C. elegans
Nutrients 2020, 12(2), 486; https://doi.org/10.3390/nu12020486 (registering DOI) - 14 Feb 2020
Abstract
Background: We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and C. elegans, and compare them with calorie restriction. Methods: [...] Read more.
Background: We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and C. elegans, and compare them with calorie restriction. Methods: Whole transcriptomic analysis was performed in the brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. Longevity and vitality were tested in C. elegans. Results: The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and different from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to aging, were the most affected. Furthermore, a functional analysis in C. elegans was used. We found that feeding C. elegans the micronutrient blend increased longevity as well as vitality. Conclusions: We describe a micronutrient supplement that causes similar changes (transcriptomic and promoting longevity and vitality) as a calorie restriction in mice and C. elegans, respectively, but further studies are required to confirm these effects in humans. Full article
(This article belongs to the Special Issue Dietary Restriction and Lifespan)
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