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Nutrients
Special Issues
Hot Topics in Clinical Nutrition (2nd Edition)
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Special Issue "Hot Topics in Clinical Nutrition (2nd Edition)"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 November 2023 | Viewed by 2889

Special Issue Editors

Prof. Dr. Antonio Gasbarrini

grade E-Mail Website1 Website2
Guest Editor
1. Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy
2. Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: gastroenterology; oncology; digestive cancer; diverticular disease; cancer prevention; inflammatory bowel diseases; microbial communities; bioinformatics and computational biology
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuele Rinninella

E-Mail Website
Guest Editor
1. Research and Training Center in Human Nutrition, Catholic University of Sacred Heart, 00168 Rome, Italy
2. Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: clinical nutrition; perioperative nutrition; body composition; gut microbiota dietary modulation; digestive cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the previous collection of papers focusing on "Hot Topics in Clinical Nutrition", we would like to arrange another platform for scientific contributions on the matter in order to present new breakthrough articles in clinical nutrition science; this Special Issue maintains the same editorial line as the previous one. The modulation of gut microbiota and related health issues, such as metabolic, inflammatory, and neoplastic diseases, in addition to the impact of novel foods (including artificial foods) and additive as well as processed foods on human health are arguments of interest. Moreover, articles debating the role of nutritional support in disease-related malnutrition (due to cancer or acute and chronic inflammation) and perioperative nutrition are welcomed, as are manuscripts concerning the role of food waste (and environmental consequences) and strategies with which to deal with it. Original studies as well as meta-analyses/systematic reviews or well-prepared narrative ones are welcomed.

Prof. Dr. Antonio Gasbarrini
Dr. Emanuele Rinninella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • food additives
  • novel foods, artificial foods
  • processed foods
  • non-communicable diseases
  • cancer
  • malnutrition
  • food wasting
  • environment
  • ERAS (enhanced recovery after surgery)
  • nutritional support

Published Papers (3 papers)

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Research

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Article
n-3 PUFA-Enriched Diet Preserves Skeletal Muscle Mitochondrial Function and Redox State and Prevents Muscle Mass Loss in Mice with Chronic Heart Failure
by
Gianluca Gortan Cappellari
,
Aneta Aleksova
,
Matteo Dal Ferro
,
Antonio Cannatà
,
Annamaria Semolic
,
Alberto Guarnaccia
,
Michela Zanetti
,
Mauro Giacca
,
Gianfranco Sinagra
and
Rocco Barazzoni
Nutrients 2023, 15(14), 3108; https://doi.org/10.3390/nu15143108 - 11 Jul 2023
Viewed by 797
Abstract
Rationale and Methods: Skeletal muscle derangements, potentially including mitochondrial dysfunction with altered mitochondrial dynamics and high reactive oxygen species (ROS) generation, may lead to protein catabolism and muscle wasting, resulting in low exercise capacity and reduced survival in chronic heart failure (CHF). We [...] Read more.
Rationale and Methods: Skeletal muscle derangements, potentially including mitochondrial dysfunction with altered mitochondrial dynamics and high reactive oxygen species (ROS) generation, may lead to protein catabolism and muscle wasting, resulting in low exercise capacity and reduced survival in chronic heart failure (CHF). We hypothesized that 8-week n-3-PUFA isocaloric partial dietary replacement (Fat = 5.5% total cal; EPA + DHA = 27% total fat) normalizes gastrocnemius muscle (GM) mitochondrial dynamics regulators, mitochondrial and tissue pro-oxidative changes, and catabolic derangements, resulting in preserved GM mass in rodent CHF [Myocardial infarction (MI)-induced CHF by coronary artery ligation, left-ventricular ejection fraction <50%]. Results: Compared to control animals (Sham), CHF had a higher GM mitochondrial fission-fusion protein ratio, with low ATP and high ROS production, pro-inflammatory changes, and low insulin signalling. n-3-PUFA normalized all mitochondrial derangements and the pro-oxidative state (oxidized to total glutathione ratio), associated with normalized GM cytokine profile, and enhanced muscle-anabolic insulin signalling and prevention of CHF-induced GM weight loss (all p < 0.05 vs. CHF and p = NS vs. S). Conclusions: n-3-PUFA isocaloric partial dietary replacement for 8 weeks normalizes CHF-induced derangements of muscle mitochondrial dynamics regulators, ROS production and function. n-3-PUFA mitochondrial effects result in preserved skeletal muscle mass, with potential to improve major patient outcomes in clinical settings. Full article
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition (2nd Edition))
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Article
Effects of Treatment with Liraglutide Early after Surgical Intervention on Clinical Outcomes in Patients with Short Bowel Syndrome: A Pilot Observational “Real-Life” Study
by
Fabio Dario Merlo
,
Umberto Aimasso
,
Marta Ossola
,
Mirko Ippolito
,
Leila Cravero
,
Valentina Ponzo
and
Simona Bo
Nutrients 2023, 15(12), 2740; https://doi.org/10.3390/nu15122740 - 14 Jun 2023
Viewed by 772
Abstract
Liraglutide, a glucagon-like peptide-1 agonist, has been shown to have beneficial effects on fecal output in short bowel syndrome (SBS) by small human studies. Its potential effects early after gut resection are not known. In this pilot observational study, we described the 1- [...] Read more.
Liraglutide, a glucagon-like peptide-1 agonist, has been shown to have beneficial effects on fecal output in short bowel syndrome (SBS) by small human studies. Its potential effects early after gut resection are not known. In this pilot observational study, we described the 1- and 6-month liraglutide effects in 19 adult patients with a new SBS diagnosis within 1 month after surgical resection. Stomal/fecal and urinary outcomes, serum/urinary electrolytes, and body composition were assessed. Both within-group differences and between-group comparisons with 20 SBS patients refusing liraglutide treatment were evaluated. The main liraglutide-related side effect was mild nausea, except in one patient, who experienced severe nausea/vomiting. The median ostomy/fecal output was significantly reduced by −550 mL/day after 6 months of treatment (vs. −200 mL/day in untreated, p = 0.04). The number of patients reaching a ≥20% output reduction was 10/19 (52.6%) treated vs. 3/20 (15.0%) untreated patients (p = 0.013) at 1 month and 12/19 (63.2%) vs. 6/20 (30.0%) (p = 0.038) at 6 months, respectively. Participants with a clinically relevant output reduction at 6 months had a significantly lower baseline weight and BMI. Energy parenteral supply significantly decreased, while infused volumes, oral energy, and fluid intakes slightly decreased, though not significantly. This pilot study supports liraglutide benefits in ostomy/fecal output early after surgical gut resection in SBS patients, particularly in those with lower baseline weight values. Full article
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition (2nd Edition))
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Article
New Insights and Evidence on “Food Intolerances”: Non-Celiac Gluten Sensitivity and Nickel Allergic Contact Mucositis
by
Nicoletta Greco
,
Annalinda Pisano
,
Laura Mezzatesta
,
Marta Pettinelli
,
Arianna Meacci
,
Maria Gemma Pignataro
,
Carla Giordano
and
Antonio Picarelli
Nutrients 2023, 15(10), 2353; https://doi.org/10.3390/nu15102353 - 17 May 2023
Viewed by 1118
Abstract
The clinical examination of patients often includes the observation of the existence of a close relationship between the ingestion of certain foods and the appearance of various symptoms. Until now, the occurrence of these events has been loosely defined as food intolerance. Instead, [...] Read more.
The clinical examination of patients often includes the observation of the existence of a close relationship between the ingestion of certain foods and the appearance of various symptoms. Until now, the occurrence of these events has been loosely defined as food intolerance. Instead, these conditions should be more properly defined as adverse food reactions (AFRs), which can consist of the presentation of a wide variety of symptoms which are commonly identified as irritable bowel syndrome (IBS). In addition, systemic manifestations such as neurological, dermatological, joint, and respiratory disorders may also occur in affected patients. Although the etiology and pathogenesis of some of them are already known, others, such as non-celiac gluten sensitivity and adverse reactions to nickel-containing foods, are not yet fully defined. The study aimed to evaluate the relationship between the ingestion of some foods and the appearance of some symptoms and clinical improvements and detectable immunohistochemical alterations after a specific exclusion diet. One hundred and six consecutive patients suffering from meteorism, dyspepsia, and nausea following the ingestion of foods containing gluten or nickel were subjected to the GSRS questionnaire which was modified according to the “Salerno experts’ criteria”. All patients underwent detection of IgA antibodies to tissue transglutaminase, oral mucosal patch tests with gluten and nickel (OMPT), and EGDS, including biopsies. Our data show that GSRS and OMPT, the use of APERIO CS2 software, and the endothelial marker CD34 could be suggested as useful tools in the diagnostic procedure of these new pathologies. Larger, multi-center clinical trials could be helpful in defining these emerging clinical problems. Full article
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition (2nd Edition))
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