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Nutrients
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Chronic Kidney Diseases: Multimodal Nutrition Management and Outcomes
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Chronic Kidney Diseases: Multimodal Nutrition Management and Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (26 September 2023) | Viewed by 1791

Special Issue Editor

Dr. Ko-Lin Kuo

E-Mail Website
Guest Editor
Division of Nephrology, Taipei Tzu-Chi Hospital, New Taipei 231, Taiwan
Interests: anemia; angiogenesis; atherosclerosis; dialysis; endothelial dysfunction; epidemiology; iron metabolism; kidney disease; oxidative stress; renal nutrition; uremic toxins; vegetarian diet

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is characterized by a progressive decline in glomerular filtration rate or persistent proteinuria for more than 3 months. CKD itself may lead to maladaptive repair and accelerated renal fibrosis by hyperactivity of the sympathetic tone, renin–angiotensin–aldosterone system, deregulation of redox homeostasis and inflammatory response, as well as increased accumulation of gut-derived uremic toxin. These metabolic changes further accelerate glomerular sclerosis and sequential tubulointerstitial fibrosis. The current pharmacologic treatment of CKD is not satisfactory; CKD patients are also suggested for dietary intervention with protein restriction to lessen kidney disease progression. On the other hand, CKD and dialysis patients are associated with a high risk of malnutrition. Keeping a balance between protein restriction and malnutrition is of the utmost importance. Therefore, seeking potential, nutritional interventions for CKD with improvement of the clinical outcome will be needed. To this end, we sincerely invite researchers to contribute their research works to the Special Issue, entitled " Chronic Kidney Diseases: Multimodal Nutrition Management and Outcomes ", which aims to provide a research platform for the collection of original research articles and the latest reviews which cover all aspects of kidney diseases or dialysis.

Dr. Ko-Lin Kuo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • dietary pattern
  • gut–kidney axis
  • microbiota
  • nutriceuticals
  • reactive oxygen species
  • renal nutrition
  • uremic toxins

Published Papers (1 paper)

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Research

15 pages, 1329 KiB  
Article
Exploring the Link between Chronic Kidney Disease and Parkinson’s Disease: Insights from a Longitudinal Study Using a National Health Screening Cohort
by Mi Jung Kwon, Jwa-Kyung Kim, Ji Hee Kim, Joo-Hee Kim, Min-Jeong Kim, Nan Young Kim, Hyo Geun Choi and Eun Soo Kim
Nutrients 2023, 15(14), 3205; https://doi.org/10.3390/nu15143205 - 19 Jul 2023
Cited by 1 | Viewed by 1292
Abstract
Chronic kidney disease (CKD) and Parkinson’s disease (PD) are common illnesses found in the geriatric population. A potential link between CKD and PD emergence has been hypothesized; however, existing conclusions are disputed. In this longitudinal research, we analyzed data acquired from the Korean [...] Read more.
Chronic kidney disease (CKD) and Parkinson’s disease (PD) are common illnesses found in the geriatric population. A potential link between CKD and PD emergence has been hypothesized; however, existing conclusions are disputed. In this longitudinal research, we analyzed data acquired from the Korean National Health Insurance Service-Health Screening Cohort. The dataset comprised the health information of 16,559 individuals clinically diagnosed with CKD and 66,236 control subjects of comparable ages, all aged ≥40 years. These subjects participated in health examinations from 2002 to 2019. To assess the correlation between CKD and PD, we employed overlap-weighted Cox proportional hazard regression models. The unadjusted, crude hazard ratio for PD was greater in the CKD group than in the control group (crude hazard ration (HR) 1.20; 95% confidence interval (CI) = 1.04–1.39; p = 0.011). However, the Cox proportional hazard regression analysis, incorporating propensity score overlap weighting, revealed no significant discrepancy after considering confounding variables such as demographic factors, socio-economic status, lifestyle, and concurrent health conditions (adjusted HR (aHR), 1.09; 95% CI = 0.97–1.22; p = 0.147). Subgroup analyses showed a higher probability of PD development among certain CKD individuals, including those who resided in rural areas (aHR, 1.19; 95% CI = 1.03–1.37; p = 0.022), maintained a normal weight (aHR, 1.29; 95% CI = 1.08–1.56; p = 0.006), or had fasting blood glucose levels ≥100 mg/dL (aHR, 1.18; 95% CI = 1.00–1.39; p = 0.046). Therefore, these clinical or environmental factors may influence the incidence of PD in CKD patients. In conclusion, our results suggest that the general CKD population may not exhibit a greater propensity for PD than their non-CKD counterparts. However, this might be contingent upon specific lifestyle and comorbid conditions. Thus, certain lifestyle alterations could be crucial in mitigating the potential manifestation of PD in patients diagnosed with CKD. Full article
(This article belongs to the Special Issue Chronic Kidney Diseases: Multimodal Nutrition Management and Outcomes)
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