Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.1
5.0
Journals
Nutrients
Special Issues
Lipids and Lipoproteins in Cardiovascular Diseases
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Lipids and Lipoproteins in Cardiovascular Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1428

Special Issue Editor

Prof. Dr. Aline Marcadenti

E-Mail Website
Guest Editor
Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre 90620-001, RS, Brazil
Interests: nutritional assessment; nutrition; cardiology and endocrinology; obesity; hypertension; type 2 diabetes mellitus; dyslipidemia; cardiovascular disease of atherosclerotic origin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Disorders in lipid and fatty acid metabolism are among the primary risk factors for the development of atherosclerosis and the genesis of cardiovascular diseases. These molecules may undergo changes due to genetic alterations as well as secondary causes. In this context, the intake of specific nutrients and the selection of dietary patterns play a crucial role in both the progression and treatment of lipid and lipoprotein disorders. Furthermore, diet can interact with genomic elements in the modulation of these biomarkers.

In this Special Issue, we encourage the submission of articles that evaluate the role of dietary patterns and nutrients in the modulation of fatty acids, lipids, and lipoproteins within the context of primordial, primary, and secondary prevention of cardiovascular disease related to atherosclerosis. Additionally, articles describing interactions between diet and molecular elements concerning different phenotypes of hyperlipoproteinemia are welcome. We will consider original articles (pilot studies, experimental studies, and observational studies), as well as narrative, scoping, and systematic reviews (with or without meta-analyses) and clinical study protocols. Studies conducted on animal and cellular models, as well as those utilizing Mendelian randomization methods, will also be taken into account.

Prof. Dr. Aline Marcadenti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • dietary patterns
  • nutrients
  • fatty acids
  • lipids
  • lipoproteins
  • dyslipidemias
  • atherosclerosis
  • genomics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

23 pages, 858 KiB  
Article
An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial
by Erlon Oliveira de Abreu-Silva, Rachel Helena Vieira Machado, Bianca Rodrigues dos Santos, Flávia Cristina Soares Kojima, Renato Hideo Nakagawa Santos, Karina do Lago Negrelli, Letícia Barbante Rodrigues, Pedro Gabriel Melo de Barros e Silva, Andressa Gusmão de Lima, João Gabriel Sanchez, Fernanda Jafet El Khouri, Ângela Cristine Bersch-Ferreira, Adriana Bastos Carvalho, Thaís Martins de Oliveira, Maria Cristina Izar, Geni Rodrigues Sampaio, Nágila Raquel Teixeira Damasceno, Marcelo Macedo Rogero, Elizabeth Aparecida Ferraz da Silva Torres, Flávia De Conti Cartolano, Julia Pinheiro Krey, Patrícia Vieira de Luca, Cristiane Kovacs Amaral, Elisa Maia dos Santos, Rodrigo Morel Vieira de Melo, Eduardo Gomes Lima, André de Luca dos Santos, Thiago Gomes Heck, Ana Paula Perillo Ferreira Carvalho, Silvia Bueno Garofallo, Alexandre Biasi Cavalcanti and Aline Marcadentiadd Show full author list remove Hide full author list
Nutrients 2025, 17(12), 2008; https://doi.org/10.3390/nu17122008 - 15 Jun 2025
Viewed by 1099
Abstract
Background/Objectives: Familial hypercholesterolemia (FH) is an increasingly common inherited disorder that increases cardiovascular risk. Despite the importance of lifestyle interventions, adherence to a healthy diet among individuals with FH remains suboptimal. This pilot, multicenter, double-blind, placebo-controlled randomized trial aimed to evaluate the feasibility [...] Read more.
Background/Objectives: Familial hypercholesterolemia (FH) is an increasingly common inherited disorder that increases cardiovascular risk. Despite the importance of lifestyle interventions, adherence to a healthy diet among individuals with FH remains suboptimal. This pilot, multicenter, double-blind, placebo-controlled randomized trial aimed to evaluate the feasibility and preliminary effects of a culturally adapted cardioprotective diet (DICA-FH), alone or in combination with phytosterol and/or krill oil supplementation, on lipid parameters in Brazilian adults with probable or definitive FH. Methods: Between May and August 2023, 58 participants were enrolled across nine Brazilian centers and randomized (1:1:1:1) into four groups: DICA-FH + phytosterol placebo + krill oil placebo; DICA-FH + phytosterol 2 g/day + krill oil placebo; DICA-FH + phytosterol placebo + krill oil 2 g/day; and DICA-FH + phytosterol 2 g/day + krill oil 2 g/day. Interventions lasted 120 days. The primary outcomes were mean low-density lipoprotein cholesterol (LDL-c) and lipoprotein(a) (Lp[a]) levels, as well as adherence to treatment at follow-up. Secondary outcomes included mean levels of other lipids, frequency of adverse events, and assessment of protocol implementation components. All data were presented separately for the allocation groups: phytosterol vs. placebo and krill oil vs. placebo. Results: Mean age was 54.5 ± 13.7 years, and 58.6% were women. Both adherence to protocol (91.8% attendance; 79.1% investigational product intake) and retention (86.2%) were high. No significant differences between groups were found for LDL-c or Lp(a). However, regardless of allocation to active supplementation or placebo, a significant reduction in Lp(a) concentrations was observed following the DICA-FH intervention (median difference: −3.8 mg/dL [interquartile range: −7.5 to −1.2]; p < 0.01). Significant reductions in oxidized LDL (LDL-ox) and LDL-ox/LDL-c ratio were also observed in the overall sample (p < 0.01). Although not statistically significant, all groups showed improvements in diet quality after 120 days. No serious adverse events related to the interventions were reported. Additionally, most protocol implementation components were successfully achieved. Conclusions: The DICA-FH strategy, with or without supplementation, was safe and well-tolerated. Although not powered to detect clinical efficacy (which is acceptable in exploratory pilot trials), the study supports the feasibility of a larger trial and highlights the potential of dietary interventions in the management of HF. Full article
(This article belongs to the Special Issue Lipids and Lipoproteins in Cardiovascular Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop