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The Effect of Dietary Bioactive Compounds on Inflammation-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 5 February 2026 | Viewed by 1239

Special Issue Editors


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Guest Editor
Department of Life and Environmental Sciences, Polytechnic University of Marche, 60121 Ancona, Italy
Interests: bioactive compounds; oxidative stress; inflammation; human nutrition; lipoproteins; paraoxonase 2

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Guest Editor
Department of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy
Interests: plant bioactive compounds; functional food and beverages; oxidative stress; antioxidants; lifestyle-related diseases
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Special Issue Information

Dear Colleagues,

Bioactive components are widely distributed in various plant species, where they perform several structural, metabolic, and defense functions.

These plant food elements have been shown to possess beneficial properties, including immunomodulatory, antioxidant, anti-inflammatory, and antimicrobial effects. The possible role that these compounds play in the prevention or treatment of several pathologies, such as cancer, diabetes, metabolic syndrome, or neurodegenerative diseases, is being continuously analyzed.

The purpose of this Special Issue, entitled "The Effect of Dietary Bioactive Compounds on Inflammation-Related Diseases", is to collect and discuss the recent developments in research regarding all of the aspects of bioactive compounds that are involved in various diseases, mediated by inflammatory and oxidative processes. More specifically, original papers should focus on the implication of dietary bioactive compounds in different molecular pathways and propose modern cell and molecular biology methodologies. Furthermore, considering bioavailability as a key element to ensure the bio-efficacy of these compounds, studies on the absorption and metabolism of dietary bioactive compounds are particularly welcome. This Special Issue welcomes the submission of both original scientific research and systematic reviews.

Dr. Camilla Morresi
Dr. Tiziana Bacchetti
Guest Editors

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Keywords

  • polyphenols
  • chronic diseases
  • inflammation
  • nutrients
  • diet
  • supplements
  • human health
  • oxidative stress

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Published Papers (1 paper)

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Research

28 pages, 5633 KiB  
Article
Investigation into Efficacy and Mechanisms of Neuroprotection of Ashwagandha Root Extract and Water-Soluble Coenzyme Q10 in a Transgenic Mouse Model of Alzheimer’s Disease
by Caleb Vegh, Gabrielle Walach, Keanna Dube, Bromleigh Dobson, Rohan Talukdar, Darcy Wear, Hasana Jayawardena, Kaitlyn Dufault, Lauren Culmone, Subidsa Srikantha, Iva Okaj, Rachel Huggard, Jerome Cohen and Siyaram Pandey
Nutrients 2025, 17(16), 2701; https://doi.org/10.3390/nu17162701 - 20 Aug 2025
Viewed by 266
Abstract
Background: Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders and the most common form of dementia. Although current treatments examine disease progression, many have side effects and primarily target symptomatic relief as opposed to halting further neurodegeneration. Objective: The current [...] Read more.
Background: Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders and the most common form of dementia. Although current treatments examine disease progression, many have side effects and primarily target symptomatic relief as opposed to halting further neurodegeneration. Objective: The current study aims to determine the neuroprotective effects of water-soluble coenzyme Q10 (Ubisol-Q10) and an ethanolic Ashwagandha extract (E-ASH) on a transgenic mouse model of AD. Methods: A variety of immunofluorescence staining of biomarkers was conducted to assess mechanisms commonly implicated in the disease. Additionally, spatial and non-spatial memory tests evaluated cognitive functions at two timepoints throughout the progression of the disease. Results: A substantial reduction in microglial activation and amyloid-β (Aβ) plaques when treated with a combination of natural health products (NHPs), Ubisol-Q10 and E-ASH. Moreover, activation of autophagy was upregulated in both the Ubisol-Q10 and combination (Ubisol-Q10+E-ASH given as a combined “Tonic” solution) groups. Oxidative stress was decreased across treated groups, while astrocyte activation was elevated in both the E-ASH and Tonic group. The Tonic group expressed an elevation in the fluorescent intensity of neuronal nuclei (NeuN) and brain-derived neurotrophic factor (BDNF) levels. Interestingly, treatment with E-ASH and Ubisol-Q10 enhanced synaptic vesicle formation compared to controls. Pre-mortem memory tests revealed the treatments to be effective at preserving cognitive abilities. Conclusions: Based on these findings, the combination of E-ASH and Ubisol-Q10 may effectively mitigate the various mechanisms implicated in AD and ultimately prevent further disease progression. Full article
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