nutrients-logo

Journal Browser

Journal Browser

The Effect of Dietary Bioactive Compounds on Inflammation-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (5 February 2026) | Viewed by 4315

Special Issue Editors


E-Mail Website
Guest Editor
Department of Life Sciences, Health, and Health Professions, Link Campus University, 00165 Rome, Italy
Interests: bioactive compounds; oxidative stress; inflammation; human nutrition; lipoproteins; paraoxonase 2
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy
Interests: plant bioactive compounds; functional food and beverages; oxidative stress; antioxidants; lifestyle-related diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive components are widely distributed in various plant species, where they perform several structural, metabolic, and defense functions.

These plant food elements have been shown to possess beneficial properties, including immunomodulatory, antioxidant, anti-inflammatory, and antimicrobial effects. The possible role that these compounds play in the prevention or treatment of several pathologies, such as cancer, diabetes, metabolic syndrome, or neurodegenerative diseases, is being continuously analyzed.

The purpose of this Special Issue, entitled "The Effect of Dietary Bioactive Compounds on Inflammation-Related Diseases", is to collect and discuss the recent developments in research regarding all of the aspects of bioactive compounds that are involved in various diseases, mediated by inflammatory and oxidative processes. More specifically, original papers should focus on the implication of dietary bioactive compounds in different molecular pathways and propose modern cell and molecular biology methodologies. Furthermore, considering bioavailability as a key element to ensure the bio-efficacy of these compounds, studies on the absorption and metabolism of dietary bioactive compounds are particularly welcome. This Special Issue welcomes the submission of both original scientific research and systematic reviews.

Dr. Camilla Morresi
Dr. Tiziana Bacchetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • chronic diseases
  • inflammation
  • nutrients
  • diet
  • supplements
  • human health
  • oxidative stress

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1206 KB  
Article
Inhibitory Effect of Canavalia gladiata Extract on Aggregatibacter actinomycetemcomitans LPS Induced Nitric Oxide in Macrophages
by Eun-Sook Kim, Yun-Seong Lee, Jooyi Kang, Kang-Ju Kim and Yong-Ouk You
Nutrients 2025, 17(23), 3764; https://doi.org/10.3390/nu17233764 - 30 Nov 2025
Cited by 1 | Viewed by 609
Abstract
Objectives: Canavalia gladiata (Jacq.) DC. (C. gladiata) has been used in traditional medicine to treat suppurative inflammatory conditions. Its antibacterial activity against oral pathogens and potential use as a non-alcoholic mouthwash have also been reported. This study aimed to elucidate [...] Read more.
Objectives: Canavalia gladiata (Jacq.) DC. (C. gladiata) has been used in traditional medicine to treat suppurative inflammatory conditions. Its antibacterial activity against oral pathogens and potential use as a non-alcoholic mouthwash have also been reported. This study aimed to elucidate the biological activity of Con A from C. gladiata, evaluate nitric oxide (NO) production induced by Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), and as-sess its potential association with periodontal inflammation. Methods: In this study, a 0.5 M NaCl extract of C. gladiata (CGENa) was prepared, and its protein content was quantified. The Concanavalin A equivalent (Con Aeq.) of CGENa was determined via a hemagglutination assay, and its effect on NO production was evaluated in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS-A.a.) derived from A. actinomycetemcomitans. LPS was extracted from six A. actinomycetemcomitans strains and used to induce inflammatory activation. Result: CGENa treatment significantly inhibited LPS-induced NO production at concentrations below 6.25 μg/mL without cytotoxic effects, suggesting an anti-inflammatory potential associated with lectin-like components. Conclusions: These results suggest that C. gladiata extract suppresses LPS-A.a.-mediated macrophage activation. Further studies are required to determine whether Con A specifically mediates this response and to evaluate its therapeutic relevance in the context of periodontal inflammation. Full article
Show Figures

Graphical abstract

28 pages, 5633 KB  
Article
Investigation into Efficacy and Mechanisms of Neuroprotection of Ashwagandha Root Extract and Water-Soluble Coenzyme Q10 in a Transgenic Mouse Model of Alzheimer’s Disease
by Caleb Vegh, Gabrielle Walach, Keanna Dube, Bromleigh Dobson, Rohan Talukdar, Darcy Wear, Hasana Jayawardena, Kaitlyn Dufault, Lauren Culmone, Subidsa Srikantha, Iva Okaj, Rachel Huggard, Jerome Cohen and Siyaram Pandey
Nutrients 2025, 17(16), 2701; https://doi.org/10.3390/nu17162701 - 20 Aug 2025
Viewed by 2519
Abstract
Background: Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders and the most common form of dementia. Although current treatments examine disease progression, many have side effects and primarily target symptomatic relief as opposed to halting further neurodegeneration. Objective: The current [...] Read more.
Background: Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders and the most common form of dementia. Although current treatments examine disease progression, many have side effects and primarily target symptomatic relief as opposed to halting further neurodegeneration. Objective: The current study aims to determine the neuroprotective effects of water-soluble coenzyme Q10 (Ubisol-Q10) and an ethanolic Ashwagandha extract (E-ASH) on a transgenic mouse model of AD. Methods: A variety of immunofluorescence staining of biomarkers was conducted to assess mechanisms commonly implicated in the disease. Additionally, spatial and non-spatial memory tests evaluated cognitive functions at two timepoints throughout the progression of the disease. Results: A substantial reduction in microglial activation and amyloid-β (Aβ) plaques when treated with a combination of natural health products (NHPs), Ubisol-Q10 and E-ASH. Moreover, activation of autophagy was upregulated in both the Ubisol-Q10 and combination (Ubisol-Q10+E-ASH given as a combined “Tonic” solution) groups. Oxidative stress was decreased across treated groups, while astrocyte activation was elevated in both the E-ASH and Tonic group. The Tonic group expressed an elevation in the fluorescent intensity of neuronal nuclei (NeuN) and brain-derived neurotrophic factor (BDNF) levels. Interestingly, treatment with E-ASH and Ubisol-Q10 enhanced synaptic vesicle formation compared to controls. Pre-mortem memory tests revealed the treatments to be effective at preserving cognitive abilities. Conclusions: Based on these findings, the combination of E-ASH and Ubisol-Q10 may effectively mitigate the various mechanisms implicated in AD and ultimately prevent further disease progression. Full article
Show Figures

Figure 1

Back to TopTop