Special Issue "The Role of Triglycerides and Triglyceride Metabolism in Human Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 May 2021.

Special Issue Editors

Prof. John Mamo
E-Mail Website
Guest Editor
Faculty of Health Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; postprandial lipoproteins; cardiovascular disease; cerebrovascular disease; neurodegenerative disorders
Assoc. Prof. Ryu Takechi
E-Mail Website
Guest Editor
Faculty of Health Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; triglyceride-rich lipoproteins; cardiovascular disease; neurodegenerative disorders; endocrine disorders
Dr. Virginie Lam
E-Mail Website
Guest Editor
School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; triglyceride-rich lipoproteins; cardiovascular disease; neurodegenerative disorders; endocrine disorders

Special Issue Information

Dear Colleagues,

There is accumulating evidence that elevated plasma triglyceride levels are a risk factor for cardiovascular and cerebrovascular disorders including stroke, and for metabolic diseases such as diabetes. Aberrations in the metabolism of triglyceride-rich lipoproteins and their remnants are increasingly considered pathogenic, much like low-density lipoprotein, however the mechanisms of causality are less clear.

The Nutrients Special Issue titled “The Role of Triglycerides and Triglyceride Metabolism in Human Health” seeks to provide contemporary consideration of how the metabolism of triglycerides and of triglyceride-rich lipoproteins contributes to human health, especially the etiology of vascular-based disorders. The Special Issue seeks to include, but to also expand knowledge beyond, cardiovascular disease and atherosclerosis. Submissions with a focus on cerebrovascular and neurodegenerative disorders, peripheral vascular disease, as well as metabolic and/or endocrine dysfunction are strongly encouraged.

We hope you find this Special Issue “The Role of Triglycerides and Triglyceride Metabolism in Human Health” to be timely, and appreciate your positive consideration to submit.

Prof. John Mamo 
Assoc. Prof. Ryu Takechi
Dr. Virginie Lam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Triglycerides
  • Triglyceride-rich lipoproteins
  • Vascular disease
  • Metabolic health

Published Papers (1 paper)

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Research

Open AccessArticle
Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein
Nutrients 2021, 13(4), 1224; https://doi.org/10.3390/nu13041224 - 08 Apr 2021
Viewed by 366
Abstract
Impaired triglyceride-rich lipoprotein plasma catabolism is considered the most important factor for hypertriglyceridemia development. The aim of this study was to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL)-triglyceride lipolysis and the role of [...] Read more.
Impaired triglyceride-rich lipoprotein plasma catabolism is considered the most important factor for hypertriglyceridemia development. The aim of this study was to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL)-triglyceride lipolysis and the role of high-density lipoprotein (HDL) in this process. Subjects with no history of cardiovascular disease (CVD) and untreated with lipid-lowering agents were recruited into the study and divided into normolipidemic, hypercholesterolemic, and hyperlipidemic groups. VLDL was isolated from serum and incubated with LPL in the absence or presence of HDL. For the hypercholesterolemic and hyperlipidemic groups, a significantly lower percentage of hydrolyzed VLDL-triglyceride was achieved compared to the normolipidemic group (p < 0.01). HDL enhanced the lipolysis efficiency in the hypercholesterolemic and hyperlipidemic groups on average by ~7% (p < 0.001). The lowest electrophoretic mobility of the VLDL remnants indicating the most effective lipolysis was obtained in the normolipidemic group (p < 0.05). HDL presence significantly reduced the electrophoretic mobility of the VLDL remnants for the hypercholesterolemic and hyperlipidemic groups (p < 0.05). The results of our study indicate that VLDL obtained from hypercholesterolemic and hyperlipidemic subjects are more resistant to lipolysis and are additional evidence of the need for early implementation of hypocholesterolemic treatment, already in asymptomatic CVD subjects. Full article
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
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