Special Issue "Osteoporosis Prevention and Nutrition"
Deadline for manuscript submissions: 15 August 2020.
Interests: vitamin D; calcium; dairy; fragility fractures; physical activity; osteoporosis; epidemiology
It is estimated that 25 million men and 140 million women globally will have a fracture each year. About 3.5 million new fragility fractures occur annually in Europe alone and fragility fractures can, in some high-incidence countries, encompass 10% of the total health care costs. Fragility fractures therefore impose a huge personal and economic toll, and high mortality rates are often an additional consequence. With a growing number of elderly individuals, the number of fragility fracture cases is expected to double worldwide over the next 40 years, presenting significant challenges to medical systems, health care budgets and the well-being of older populations.
Hip fractures are considered the most devastating type of fragility fracture associated with substantial pain and suffering, disability, increased mortality for the individual and high costs for the society. Worldwide 1.6 million hip fractures are estimated to occur each year at an average of 80 years of age. As for fragility fractures in general, Scandinavian countries have the highest rates. Thus, a Swedish man has a higher risk of having a hip fracture than a woman from the United Kingdom, the Netherlands, or Finland, an observation that cannot readily be explained by known lifestyle or genetic determinants, climate, vitamin D status, longevity, or geographical differences in bone mineral density (BMD). The risk of hip fracture increases 44 fold in Swedish women from 55 to 85 years of age, so that the lifetime cumulative incidence of hip fracture is 25% in women and 12% in men. Hip fractures account for half of all costs imposed by fractures in the middle-aged and older populations and on average 1% total health care costs in Europe. The impact is even greater in Scandinavia given our high incidences.
To reduce the burden from fractures in society, it is important to explore preventive strategies that may impact risk and which are modifiable by intervention. According to twin studies, lifestyle for the occurrence of fragility fracture as well as bone loss prevention is becoming of greater importance with growing age. One such modifiable lifestyle factor is our diet. Much research relating to diet and bone health has historically been spent on calcium and vitamin D. However, many other nutrients and food components in our diets, as well as individual foods may influence bone health. We aim to provide a selection of different nutritional aspects for the prevention of fragility fractures in this special issue ‘Osteoporosis Prevention and Nutrition’ of Nutrients. Although not restricted to only these, some topics might be:
- Calcium and vitamin D supplementation for the prevention of fragility fractures. Who needs it?
- Dairy consumption for the prevention of fragility fractures
- A healthy diet also suitable for the prevention of fragility fractures?
- Advantages and limitations of Mendelian randomization studies to disentangle nutrients of causal importance for bone and prevention of fractures.
- Vitamin A in relation to bone health.
- Vitamin K in relation to bone turnover markers, bone health and fractures.
- Magnesium intake and bone.
- The effects of phytoestrogens on bone mineral density and fractures in postmenopausal women
- Osteomicrobiology – a novel field of research connecting intestinal microbiota with skeletal health.
Prof. Dr. Karl Michaëlsson
Manuscript Submission Information
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- Vitamin D
- Vitamin A and retinol
- Healthy diet