Nutrition in Bone and Vascular Health: The Journey from Pathophysiology to Treatment

Dear Colleagues,

Bone disease involving fragility fractures (FFs) from osteoporosis and cardiovascular disease (CVD) are the two major causes of death worldwide. Therefore, it is very important to maintain bone and the vascular system in good status in order to adopt better strategies to prevent FFs and CVD. In this context, the association with chronic kidney disease (CKD) amplifies both fractures and CVD, especially in patients in end-stage renal disease (ESRD).

A healthy diet combined with exercise represents the best preventive approach. It is well-established that a dietary supplementation with calcium and vitamin D in postmenopausal women can decrease fracture risk. Furthermore, adequate vitamin K intake, combined with calcium and vitamin D, not only improves bone health (especially in terms of bone quality) but also prevents soft tissue calcifications through the action of the matrix Gla protein (MGP: a vitamin-K-dependent protein). Magnesium is another relevant player both for the formation of hydroxyapatite and also to reduce vascular calcifications (VCs).

This supplement will collect reviews aimed at describing the best available evidence in the field.

Dr. Maria Fusaro
Dr. Giovanni Tripepi
Prof. Dr. Maurizio Gallieni
Guest Editor

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