Interactions Between Diet and Gut Microbiota: The Prevention and Management of Obesity and Diabetes

Dear Colleagues,

Diet–microbiota crosstalk is emerging as a modifiable axis in the prevention and management of obesity and type 2 diabetes; nevertheless, important evidence gaps persist. We still need robust new studies, rigorous syntheses, and practice-relevant conclusions. This Special Issue will gather original articles and reviews that clarify how dietary patterns, foods, and bioactives shape the gastrointestinal microbiome and its metabolites to influence glycemic control, energy metabolism, adiposity, inflammation, and overall metabolic health; we invite you to be part of it.

We invite original research, brief reports, and reviews that, among others, (i) integrate diet assessment with microbiome and metabolome profiling to define microbiome-directed nutrition; (ii) test prebiotic/probiotic/synbiotic/postbiotic and dietary strategies to improve glycemia and adiposity; (iii) use longitudinal cohorts, randomized controlled trials, and well-designed preliminary studies to link microbiome dynamics with obesity and diabetes outcomes; and (iv) state-of-the-art review articles that synthesize current knowledge at the interface of diet, the gastrointestinal microbiome, and metabolic disease. Methodological papers are also encouraged.

This Special Issue aims to consolidate this evidence into clinically meaningful nutrition. We welcome contributions across the continuum—from mechanistic and multi-omics studies to pilot and pragmatic intervention trials, as well as authoritative narrative reviews—that clarify mechanisms, document and contextualize effect sizes on glycemia and adiposity, and outline biomarkers and frameworks for risk stratification and therapy. As a researcher focused on cardiometabolic risk, I am intrigued by the microbiome’s therapeutic potential and invite contributions that advance actionable nutrition for obesity and diabetes.

Dr. Anna Maria Rychter
Guest Editor

Manuscript Submission Information

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