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Micronutrients and Breast Cancer
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Micronutrients and Breast Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 19921

Special Issue Editor

Prof. Dr. Caixia Zhang

E-Mail Website
Guest Editor
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Interests: chronic diseases epidemiology; nutritional factors and incidence and prognosis of breast and colorectal cancer; cancer epidemiology; maternal and child nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Breast cancer is the most commonly diagnosed cancer in women and the leading cause of cancer mortality globally, but with the emergence of new treatments and diagnostic techniques, survival rates have improved. Nutrition plays an important role in breast cancer development and progression. Micronutrients are chemical elements or substances (such as calcium or vitamin C) that are essential in trace amounts (mg or µg) for normal growth, development, and maintenance. The associations of micronutrient intake with breast cancer risk and prognosis have always been of interest to researchers; however, thus far, their results have been unclear. We hope that papers on the associations of micronutrient intake, through diet and supplements, with breast cancer risk and prognosis will strengthen the limited data on the protective roles of micronutrients in breast cancer. Moreover, we hope that the related clinical trial will provide strong evidence of the positive effects of micronutrient supplements on prognosis and on the prevention of breast cancer. The in vivo and in vitro studies would also help to elucidate the biological mechanism of the protective effect of micronutrients in the prevention of breast cancer.

Prof. Dr. Caixia Zhang
Guest Editor

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Keywords

  • micronutrients
  • vitamins
  • minerals
  • micronutrients supplements
  • occurrence of breast cancer
  • prognosis of breast cancer

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Published Papers (5 papers)

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Research

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15 pages, 4963 KiB  
Article
The Vitamin D Receptor as a Prognostic Marker in Breast Cancer—A Cohort Study
by Linnea Huss, Igis Gulz-Haake, Emma Nilsson, Helga Tryggvadottir, Linn Nilsson, Björn Nodin, Karin Jirström, Karolin Isaksson and Helena Jernström
Nutrients 2024, 16(7), 931; https://doi.org/10.3390/nu16070931 - 23 Mar 2024
Cited by 2 | Viewed by 3525
Abstract
Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The [...] Read more.
Previous research has indicated an association between the presence of the vitamin D receptor (VDR) in breast cancer tissue and a favorable prognosis. This study aimed to further evaluate the prognostic potential of VDR located in the nuclear membrane or nucleus (liganded). The VDR protein levels were analyzed using immunohistochemistry in tumor samples from 878 breast cancer patients from Lund, Sweden, included in the Breast Cancer and Blood Study (BCBlood) from October 2002 to June 2012. The follow-up for breast cancer events and overall survival was recorded until 30 June 2019. Univariable and multivariable survival analyses were conducted, both with complete case data and with missing data imputed using multiple imputation by chained equations (MICE). Tumor-specific positive nuclear membrane VDR(num) staining was associated with favorable tumor characteristics and a longer breast cancer free interval (BCFI; HR: 0.64; 95% CI: 0.44–0.95) and overall survival (OS; HR: 0.52; 95% CI: 0.34–0.78). Further analyses indicated that VDRnum status also was predictive of overall survival when investigated in relation to ER status. There were significant interactions between VDR and invasive tumor size (Pinteraction = 0.047), as well as mode of detection (Pinteraction = 0.049). VDRnum was associated with a longer BCFI in patients with larger tumors (HR: 0.36; 95% CI: 0.14–0.93) or clinically detected tumors (HR: 0.28; 95% CI: 0.09–0.83), while no association was found for smaller tumors and screening-detected tumors. Further studies are suggested to confirm our results and to evaluate whether VDR should and could be used as a prognostic and targetable marker in breast cancer diagnostics. Full article
(This article belongs to the Special Issue Micronutrients and Breast Cancer)
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16 pages, 4224 KiB  
Article
Plasma One-Carbon Metabolism-Related Micronutrients and the Risk of Breast Cancer: Involvement of DNA Methylation
by Fubin Liu, Huijun Zhou, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Kexin Chen and Fangfang Song
Nutrients 2023, 15(16), 3621; https://doi.org/10.3390/nu15163621 - 17 Aug 2023
Viewed by 3222
Abstract
Findings of epidemiologic studies focusing on the association between one-carbon metabolism-related micronutrients and breast cancer risk, along with the involvement of DNA methylation, have been inconsistent and incomprehensive. We conducted a case–control study in China including 107 paired participants and comprehensively detected 12 [...] Read more.
Findings of epidemiologic studies focusing on the association between one-carbon metabolism-related micronutrients and breast cancer risk, along with the involvement of DNA methylation, have been inconsistent and incomprehensive. We conducted a case–control study in China including 107 paired participants and comprehensively detected 12 plasma one-carbon metabolism-related micronutrients. Genomic DNA methylation was measured using an 850 K chip and differential methylation probes (DMPs) were identified. Multivariate logistic regression was performed to estimate the associations between plasma micronutrients and the odds of breast cancer. The mediation of selected DMPs in micronutrient breast cancer associations was examined using mediation analyses. An inverse association of plasma folate, methionine cycling-related micronutrients (methionine, S-adenosylmethionine, and S-adenosylhomocysteine), and all micronutrients in the choline metabolism and enzymatic factor groups, and a positive association of methionine cycling-related cysteine with breast cancer risk were observed. Nine micronutrients (methionine, cysteine, SAM, folate, choline, betaine, P5P, vitamins B2, and B12) were related to global or probe-specific methylation levels (p < 0.05). The selected DMPs mediated the micronutrient breast cancer associations with an average mediation proportion of 36.43%. This study depicted comprehensive associations between circulating one-carbon metabolism-related micronutrients and breast cancer risk mediated by DNA methylation. Full article
(This article belongs to the Special Issue Micronutrients and Breast Cancer)
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18 pages, 3852 KiB  
Article
Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women
by Kexin Tu, Kaiyan Liu, Yifan Wang, Yiling Jiang and Caixia Zhang
Nutrients 2023, 15(14), 3253; https://doi.org/10.3390/nu15143253 - 22 Jul 2023
Cited by 5 | Viewed by 4385
Abstract
As major nonenzymatic antioxidant components in the body, dietary Zinc (Zn) and Selenium (Se) may have an impact on breast cancer development. This study aimed to investigate the relationship between dietary Zn, Se intake and breast cancer risk in Chinese women. The case-control [...] Read more.
As major nonenzymatic antioxidant components in the body, dietary Zinc (Zn) and Selenium (Se) may have an impact on breast cancer development. This study aimed to investigate the relationship between dietary Zn, Se intake and breast cancer risk in Chinese women. The case-control study included 1591 cases and 1622 age-frequency matched controls. Dietary intake was collected using a validated food frequency questionnaire. Dietary Zn and Se were divided into four categories: Zn/Se from plants, Zn/Se from meat, Zn/Se from red meat, and Zn/Se from white meat. Unconditional logistic regression models and restricted cubic spline analyses were performed to identify potential associations. Zn from white meat intake was linearly and inversely associated with breast cancer risk, and Se from red meat intake was linearly and positively associated with breast cancer risk, with adjusted odds ratio and 95% confidence interval of 0.76 (0.61–0.95) and 1.36 (1.04–1.77), respectively. Non-linear relationships were found between total dietary Zn, Zn from meat, Zn from red meat intake and breast cancer risk (pnon-linearity < 0.05). In conclusion, dietary Zn and Se intake were associated with breast cancer risk in Chinese women, and the optimal intake of Zn may be beneficial for breast cancer prevention. Full article
(This article belongs to the Special Issue Micronutrients and Breast Cancer)
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36 pages, 2034 KiB  
Review
Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol
by Christine Meyer, Aranka Brockmueller, Constanze Buhrmann and Mehdi Shakibaei
Nutrients 2024, 16(5), 708; https://doi.org/10.3390/nu16050708 - 29 Feb 2024
Cited by 4 | Viewed by 3274
Abstract
Breast cancer (BC) is currently one of the most common cancers in women worldwide with a rising tendency. Epigenetics, generally inherited variations in gene expression that occur independently of changes in DNA sequence, and their disruption could be one of the main causes [...] Read more.
Breast cancer (BC) is currently one of the most common cancers in women worldwide with a rising tendency. Epigenetics, generally inherited variations in gene expression that occur independently of changes in DNA sequence, and their disruption could be one of the main causes of BC due to inflammatory processes often associated with different lifestyle habits. In particular, hormone therapies are often indicated for hormone-positive BC, which accounts for more than 50–80% of all BC subtypes. Although the cure rate in the early stage is more than 70%, serious negative side effects such as secondary osteoporosis (OP) due to induced estrogen deficiency and chemotherapy are increasingly reported. Approaches to the management of secondary OP in BC patients comprise adjunctive therapy with bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), and cortisone, which partially reduce bone resorption and musculoskeletal pain but which are not capable of stimulating the necessary intrinsic bone regeneration. Therefore, there is a great therapeutic need for novel multitarget treatment strategies for BC which hold back the risk of secondary OP. In this review, resveratrol, a multitargeting polyphenol that has been discussed as a phytoestrogen with anti-inflammatory and anti-tumor effects at the epigenetic level, is presented as a potential adjunct to both support BC therapy and prevent osteoporotic risks by positively promoting intrinsic regeneration. In this context, resveratrol is also known for its unique role as an epigenetic modifier in the regulation of essential signaling processes—both due to its catabolic effect on BC and its anabolic effect on bone tissue. Full article
(This article belongs to the Special Issue Micronutrients and Breast Cancer)
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18 pages, 2976 KiB  
Review
A Systematic Study on Zinc-Related Metabolism in Breast Cancer
by Zheng Qu, Qiang Liu, Xiangyi Kong, Xiangyu Wang, Zhongzhao Wang, Jing Wang and Yi Fang
Nutrients 2023, 15(7), 1703; https://doi.org/10.3390/nu15071703 - 31 Mar 2023
Cited by 15 | Viewed by 4712
Abstract
Breast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease [...] Read more.
Breast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease continue to pose significant difficulties. New treatment approaches are therefore urgently required. Zinc is an important trace element that is involved in regulating various enzymatic, metabolic, and cellular processes in the human body. Several studies have shown that abnormal zinc homeostasis can lead to the onset and progression of various diseases, including breast cancer. This review highlights the role played by zinc transporters in pathogenesis, apoptosis, signal transduction, and potential clinical applications in breast cancer. Additionally, the translation of the clinical applications of zinc and associated molecules in breast cancer, as well as the recent developments in the zinc-related drug targets for breast cancer treatment, is discussed. These developments offer novel insights into understanding the concepts and approaches that could be used for the diagnosis and management of breast cancer. Full article
(This article belongs to the Special Issue Micronutrients and Breast Cancer)
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