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Nutrients
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Dietary Nutrients and Additives on Gut Microbiota and Immunity
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Dietary Nutrients and Additives on Gut Microbiota and Immunity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 4019

Special Issue Editor

Prof. Dr. Minqi Wang

E-Mail Website
Guest Editor
Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
Interests: probioticst; prebiotics; nutrients; intestinal health; immunity

Special Issue Information

Dear Colleagues,

Intestinal health and immunity are closely related to dietary nutrients and have received extensive attention in recent years. A considerable part of the dietary influences on human health and diseases are mediated or modified by the gut microbiome. Most diet-related chronic diseases are closely linked to gut microbiota and host immunity, which highlights the critical role of host immunity and microbial interactions in coordinating diet-related host health and disease.

The topic of this Special Issue is the impact of dietary nutrients and additives on gut microbiota and immunity, which will include manuscripts that focus on the complex dynamic relationship between dietary nutrients and intestinal microbiota or immunity, as well as the mechanisms by which additives such as prebiotics and probiotics, including their metabolites, act on the host intestinal nutrition and immunity, with the aim to provide nutritional strategies for intestinal microbiota regulation, improving intestinal immunity for human health. The content will be useful for enriching the theory of prevention and treatment of internal and external intestinal diseases and inspire further innovative research.

Prof. Dr. Minqi Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary
  • nutrients
  • intestinal health
  • microbiota
  • immunity

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Published Papers (2 papers)

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Research

18 pages, 5772 KiB  
Article
Indole-3-Acetic Acid Esterified with Waxy, Normal, and High-Amylose Maize Starches: Comparative Study on Colon-Targeted Delivery and Intestinal Health Impact
by Qian Gong, Xinyan Qu, Yisheng Zhao, Xingjing Zhang, Shuhua Cao, Xiao Wang, Yingying Song, Charles R. Mackay and Quanbo Wang
Nutrients 2024, 16(20), 3446; https://doi.org/10.3390/nu16203446 - 11 Oct 2024
Viewed by 2056
Abstract
Abstract: Background: Accumulating research suggests that metabolites produced by gut microbiota are essential for maintaining a balanced gut and immune system. Indole-3-acetic acid (IAA), one of tryptophan metabolites from gut microbiota, is critical for gut health through mechanisms such as activating aryl hydrocarbon [...] Read more.
Abstract: Background: Accumulating research suggests that metabolites produced by gut microbiota are essential for maintaining a balanced gut and immune system. Indole-3-acetic acid (IAA), one of tryptophan metabolites from gut microbiota, is critical for gut health through mechanisms such as activating aryl hydrocarbon receptor. Delivery of IAA to colon is beneficial for treatment of gastrointestinal diseases, and one promising strategy is IAA esterified starch, which is digested by gut microbes in colon and releases loaded IAA. Amylose content is a key structural characteristic that controls the physicochemical properties and digestibility of starch. Methods: In the current study, IAA was esterified with three typical starches with distinct amylose content to obtain indolyl acetylated waxy maize starch (WMSIAA), indolyl acetylated normal maize starch (NMSIAA), and indolyl acetylated high-amylose maize starch (HAMSIAA). The study comparatively analyzed their respective physicochemical properties, how they behave under in vitro digestion conditions, their ability to deliver IAA directly to the colon, and their effects on the properties of the gut microbiota. Results: The new characteristic peak of 1H NMR at 10.83 ppm, as well as the new characteristic peak of FTIR spectra at 1729 cm−1, represented the successful esterification of IAA on starch backbone. The following in vitro digestion study further revealed that treatment with indolyl acetylation significantly elevated the resistant starch content in the starch samples. In vivo experimental results demonstrated that WMSIAA exhibited the most significant increase in IAA levels in the stomach, whereas HAMSIAA and NMSIAA demonstrated the most remarkable increases in IAA levels in the small intestine and colon, respectively. The elevated IAA levels in the colon are conducive to promoting the growth of beneficial intestinal bacteria and significantly alleviating DSS-induced colitis. Conclusions: This research presents innovative insights and options for the advancement of colon-specific drug delivery systems aimed at preventing and curing gastrointestinal disorders. Full article
(This article belongs to the Special Issue Dietary Nutrients and Additives on Gut Microbiota and Immunity)
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21 pages, 12370 KiB  
Article
Monobutyrin Can Regulate the Gut Microbiota, Which Is Beneficial for the Development of Intestinal Barrier Function and Intestinal Health in Weaned Mice
by Haidong Wang, Ji Qiu, Minyao Zhou, Yanqiu Luo, Xinyu Li and Minqi Wang
Nutrients 2024, 16(13), 2052; https://doi.org/10.3390/nu16132052 - 27 Jun 2024
Cited by 2 | Viewed by 1627
Abstract
In this study, we investigated the effect of monobutyrin (MB) on the gut microbiota and intestinal health of weaned mice. MB was administered via gavage to 21-day-old weaned mice. Samples of small intestinal and ileal contents were collected on day 1, day 7, [...] Read more.
In this study, we investigated the effect of monobutyrin (MB) on the gut microbiota and intestinal health of weaned mice. MB was administered via gavage to 21-day-old weaned mice. Samples of small intestinal and ileal contents were collected on day 1, day 7, and day 21 post-administration. Seven days of MB administration enhanced the mucin layer and morphological structure of the intestine and the integrity of the intestinal brush border. Both MB and sodium butyrate (SB) accelerated tight junction development. Compared to SB, MB modulated intestinal T cells in a distinct manner. MB increased the ratio of Treg cells in the small intestine upon the cessation of weaning. After 21 days of MB administration, enhancement of the villus structure of the ileum was observed. MB increased the proportion of Th17 cells in the ileum. MB facilitated the transition of the small intestinal microbiota toward an adult microbial community structure and enhanced the complexity of the microbial community structure. An increase in Th17 cells enhanced intestinal barrier function. The regulatory effect of MB on Th17 cells may occur through the intestinal microbiota. Therefore, MB can potentially be used to promote intestinal barrier function, especially for weaning animals, with promising application prospects. Full article
(This article belongs to the Special Issue Dietary Nutrients and Additives on Gut Microbiota and Immunity)
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