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Nutrients
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Proceedings of the 7th International Conference “Vitamin D—Minimum, Maximum, Optimum”
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Proceedings of the 7th International Conference “Vitamin D—Minimum, Maximum, Optimum”

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 405

Special Issue Editor

Dr. Pawel Pludowski

E-Mail Website
Guest Editor
Department of Clinical Biochemistry, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
Interests: vitamin D and its pleiotropic action; guidelines of vitamin D supplementation; disturbances of calcium-phosphate metabolism; disturbances of bone tissue metabolism; body composition and biological development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

On behalf of the Organizing Committee and the Scientific Committee, I warmly welcome you all to publish your work in Nutrients, the work presented at the 7th International Conference "Vitamin D—minimum, maximum, optimum,” organized under the auspices of the European Vitamin D Association (EVIDAS). We are greatly honored to host you in this unique Special Issue (SI), graced by an exceptional group of experts from many countries around the world.

Currently, vitamin D deficiency is seen by some as a contributing factor and by others as a significant risk factor for many lifestyle diseases such as cancers, cardiovascular disease, hypertension, autoimmune diseases, metabolic diseases and disorders, infectious diseases resulting from weakened immunity, and many neurodegenerative disorders. From this SI of Nutrients, you will have the opportunity to expand your knowledge on the latest studies on the prevention and treatment of vitamin D deficiency and its impact on the development of various diseases, considering reports that document the pleiotropic effects of vitamin D.

Dear Colleagues, it remains essential and beneficial to disseminate knowledge about the importance of this crucial vitamin for the health of children, adolescents, working adults, and seniors.

Dr. Pawel Pludowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D
  • 25(OH)D
  • pleiotropic effect
  • endocrine society guidelines
  • prevention of vitamin D insufficiency
  • treatment of vitamin D deficiency

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Published Papers (1 paper)

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Research

12 pages, 209 KiB  
Article
Least Significant Change (LSC) for Serum Concentrations of 25-Hydroxyvitamin D
by Pawel Pludowski, Marek Wójcik, Maciej Jaworski, Agnieszka Ochocińska, William B. Grant and Michael F. Holick
Nutrients 2025, 17(13), 2246; https://doi.org/10.3390/nu17132246 - 7 Jul 2025
Viewed by 315
Abstract
Background: The least significant change (LSC) method should be introduced and considered a proper method to define the smallest clinically important difference between two consecutive measurements. Methods: The LSC was calculated based on 150 patients, with a total 25-hydroxyvitamin D [25(OH)D] IDS-iSYS assay [...] Read more.
Background: The least significant change (LSC) method should be introduced and considered a proper method to define the smallest clinically important difference between two consecutive measurements. Methods: The LSC was calculated based on 150 patients, with a total 25-hydroxyvitamin D [25(OH)D] IDS-iSYS assay performed in triplicate. The LSC was determined by multiplying the calculated root mean square precision error by a factor of 2.77. The study group was additionally divided into subgroups according to gender, age, serum 25(OH)D concentration, and date of assays. Results: The LSC was 4.0 ng/mL (13.2%) for the entire group (n = 150; 450 assays) and was not dependent on gender, age of patients, or the date of assays (p > 0.05). The LSC value depended only on the 25(OH)D concentration value. In the subgroup with vitamin D deficiency (<20 ng/mL), the obtained LSC value was 2.2 ng/mL (14.7%), which was lower compared to all other groups (p < 0.05 for insufficiency, and p < 0.0001 for the optimal concentration value). In the subgroup with 25(OH)D concentrations >50 ng/mL (n = 4; 12 assays), the calculated LSC was 11.8 ng/mL (16.9%) and differed statistically only from the subgroup with vitamin D deficiency (p < 0.005). Conclusions: An absolute LSC of 4.0 ng/mL was calculated for the IDS-iSYS assay used in our study and should be considered when two (or more) assay results of 25(OH)D performed for a single patient are compared. Full article
(This article belongs to the Special Issue Proceedings of the 7th International Conference “Vitamin D—Minimum, Maximum, Optimum”)
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