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Nutrients
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Health and Disease: What Will the Future of Immunometabolism and...
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Health and Disease: What Will the Future of Immunometabolism and Immunonutrition Be?

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (10 July 2025) | Viewed by 287

Special Issue Editor

Prof. Dr. Ronaldo Vagner Thomatieli-Santos

E-Mail Website
Guest Editor
Department of Biosciences, Universidade Federal de São Paulo, Santos, SP, Brazil
Interests: immunometabolism; immunonutrition; health; disease; immune system; metabolic pathways; nutrient modulation; inflammation; cellular energy; metabolism; cellular signaling; exercise
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunometabolism involves communication between the immune system, metabolism, and nutrition, and it has a strong influence on communication between various physiological systems. This Special Issue will discuss the importance of immunometabolism in promoting health and various diseases. Our focus will be on discussing possible cellular and physiological mechanisms in different contexts, such as physical exercise, acute and chronic diseases, nutrition, aging, inflammation, and other situations, that reflect the relevance of immunometabolism and can shed light on the future of the immune system, factoring in the availability of nutrients and the regulation of the human metabolism. For this Special Issue, original and review studies offering perspectives on the importance of immunometabolism are welcome.

Prof. Dr. Ronaldo Vagner Thomatieli-Santos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • immune response
  • chronic diseases
  • physical exercise
  • gut–brain axis
  • gut microbiota
  • pro-inflammatory cytokines
  • adipokines
  • bioactive compounds
  • myokines

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Published Papers (1 paper)

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Research

33 pages, 2400 KiB  
Article
Anti-Inflammatory, Antithrombotic and Antioxidant Efficacy and Synergy of a High-Dose Vitamin C Supplement Enriched with a Low Dose of Bioflavonoids; In Vitro Assessment and In Vivo Evaluation Through a Clinical Study in Healthy Subjects
by Vasiliki Chrysikopoulou, Aikaterini Rampaouni, Eleni Koutsia, Anna Ofrydopoulou, Nikolaos Mittas and Alexandros Tsoupras
Nutrients 2025, 17(16), 2643; https://doi.org/10.3390/nu17162643 - 14 Aug 2025
Abstract
Background/Objectives: Vitamin C is frequently used in several dietary supplements due to its proposed health-promoting properties, while phenolic compounds and especially flavonoids have been suggested to provide synergistic antioxidant and cardiovascular benefits. However, the specific interactions between these compounds and their individual contributions [...] Read more.
Background/Objectives: Vitamin C is frequently used in several dietary supplements due to its proposed health-promoting properties, while phenolic compounds and especially flavonoids have been suggested to provide synergistic antioxidant and cardiovascular benefits. However, the specific interactions between these compounds and their individual contributions to biological activity remain underexplored. This study aimed to evaluate the antioxidant potential and anti-inflammatory and antiplatelet biological effects of a high-dose (1 g) vitamin C–low-dose (50 mg) bioflavonoid (VCF)-based supplement using both in vitro and in vivo approaches in human platelets. Methods: Total phenolic content was quantified and antioxidant capacity was assessed using DPPH, FRAP, and ABTS assays and compared to individual phenolic standard compounds, including (simple phenolics like gallic acid, flavonoids like quercetin and catechin, and polyphenols like curcumin and tannin), and a standard supplement containing only high-dose vitamin C (VC). ATR-FTIR spectroscopy was used to assess molecular interactions between vitamin C and flavonoids. In vitro anti-inflammatory and antiplatelet activities of all supplements and standards were assessed by quantifying their IC50 values against ADP, PAF, and thrombin-induced platelet aggregation. The in vivo evaluation of the efficacy and synergy of VCF supplement versus VC was achieved by a two-arm clinical study in healthy volunteers by quantifying their platelet reactivity, which was measured via EC50 values on the aforementioned platelet agonists (PAF, ADP, and Thrombin) before (t = 0) and after receiving either solely VC or VCF supplementation for four weeks. Results: From all phenolic standards, the flavonoids and especially a mixture of flavonoids (catechin + quercetin) showed higher in vitro antioxidant capacity and anti-inflammatory and antiplatelet efficacy, followed by polyphenols and then simple phenolics. The VCF supplement showed the most potent antioxidant capacity, but also the strongest anti-inflammatory and antiplatelet activities too, in comparison to the VC and the mixture of flavonoids, suggesting higher synergy and thus bio-efficacy as a result of the co-presence of flavonoids and vitamin C in this supplement. Platelet reactivity decreased over time for PAF and thrombin in both arms of the trial, but no significant differences were observed between treatment groups, suggesting that the number of flavonoids used was not sufficient to translate the in vitro findings to the in vivo setting. Conclusions: VC-containing supplements provide antioxidant, anti-inflammatory, and antiplatelet benefits, while the incorporation of flavonoids may provide synergistic health benefits, but more in vivo assessment is needed to fully evaluate the dose efficacy. Full article
(This article belongs to the Special Issue Health and Disease: What Will the Future of Immunometabolism and Immunonutrition Be?)
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