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Nutrition and Retinal Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 5636

Special Issue Editor


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Guest Editor
BIO5 Institute, Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA
Interests: human nutrition; retinal health and disease; integrative omics; physiological imaging; model human microphysiological systems
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Special Issue Information

Dear Colleagues,

Food-based compounds and their metabolites affect the structure and function of the human retina. 

Global health research and practice initiatives are now aimed at elucidating fundamental knowledge on variations in human nutrient sensing and signaling systems for the purposes of enhancing retinal health and reducing visual impairment in diverse populations. Central to this effort are creative discoveries and innovative research strategies based on molecular nutrition.

In this Special Issue of Nutrients, we welcome state-of-the-science original research reports and systematic reviews advancing the knowledge linking the integrated roles of genetics, epigenetics, age, and gender to actions of food and nutrients in the pathogenesis and pathophysiology of common, chronic, and complex retinal diseases. 

Potential topics include, but are not limited to, the following:

  • Structural and ultrastructural studies on nutrient distributions in human and primate retinal laminae and cell types.
  • Functional studies on human microphysiological systems to characterize the mechanisms of action linking diet to retinal health and disease.
  • In vivo human studies using omics technologies and physiological imaging to identify the timing and mechanisms of action linking diet to retinal health and disease.
  • In vivo and mechanistic studies on the gut–retina axis.

Dr. John Paul SanGiovanni
Guest Editor

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Keywords

  • retina
  • nutritional biochemistry
  • nutritional biophysics keyword
  • physiological imaging

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Published Papers (1 paper)

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Review

17 pages, 1598 KiB  
Review
Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism
by Xiaonan Zhang, Mengxue Xia, Yingjie Wu and Fang Zhang
Nutrients 2023, 15(9), 2161; https://doi.org/10.3390/nu15092161 - 30 Apr 2023
Cited by 13 | Viewed by 5267
Abstract
Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein [...] Read more.
Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein synthesis, glucose metabolism, lipid metabolism, inflammation, and oxidative stress in metabolic tissues of diabetes and aging-related diseases. Recently, it has been shown that BCAAs are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. Therefore, this review summarizes the alterations of BCAA levels in retinopathy, especially diabetic retinopathy and aging-related macular disease, and the genetics, functions, and mechanisms of BCAAs in the retina as well as other metabolic tissues for reference. All of these efforts aim to provide fundamental knowledge of BCAAs for further discoveries and research on retina health based on the sensing and signaling of essential amino acids. Full article
(This article belongs to the Special Issue Nutrition and Retinal Health)
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