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Special Issue "The Health Aspects of Dietary Choline"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (15 September 2018).
Interests: one-carbon metabolism; folate; B-vitamins; choline; methylation; epigenetics; maternal nutrition; cancer nutrition; nutrition epidemiology; public health nutrition; nutritional biomarkers
Special Issues and Collections in MDPI journals
The journal Nutrients is planning a Special Issue on “The Health Aspects of Dietary Choline”. I kindly invite you and your co-workers to be part of this Special Issue by publishing your original results or a review article on the topic.
Choline is an essential nutrient for lipid metabolism, synthesis of acetylcholine, and as a source of methyl groups. Choline deficiency causes liver dysfunction and perturbations in lipid metabolism and transfer. The requirements for choline nutrients may depend on the intake of other cluster-related nutrients, such as betaine and folate. The recommendations for choline and betaine intakes and the actual intakes of these two nutrients have not been worked out in many countries. Foods contain several forms of choline, but the differential importance for health is not well established. Choline nutrient has recently gained additional interest because of its potential role in foetal programming, cognitive function at early and late ages, type 2 diabetes, and cancer.
Recent studies also suggested possible negative effects of choline on health, through interaction with gut microbiome that produces trimethylamine that in turn is absorbed and metabolized in the liver or in muscles by flavin-dependent monoaminooxydase (FMO3) to Trimethylamine-N-oxide (TMAO). TMAO is mainly excreted via the kidney. Elevated TMAO shows significant associations with vascular diseases. Consumption of foods that contain large amounts of choline or TMAO (e.g., fish) has not been shown to be associated with atherosclerosis. Most of the associations between TMAO and disease outcome could be explained by renal dysfunction.
This Special Issue will be published in the journal Nutrients and intends to address the different aspects relating choline to health and disease conditions. The aim is to communicate the newest results in the field (both original articles and review articles are accepted) to scientist working in the field. We encourage all authors to discuss the impact of their results on future studies, and to specify gaps in knowledge that would be necessary to solve in the following steps.
I welcome your proposed publication title with 3-6 explanatory sentences (max. 150 words) until 20th January 2018. The final deadline for submitting the articles is 15 July 2018. All articles will be peer reviewed and articles received before the deadline will be immediately processed. Please take note of the deadline.
It would be a great pleasure to have you as part of this Special Issue.Prof. Dr. Rima Obeid
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Choline concentration
- Nutrient-Nutrient interaction
- Randomized controlled trials
- Gut microbiome
- Choline intake