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Nutrition, Metabolites, and Human Health—3rd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 451

Special Issue Editor


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Guest Editor
1. Institute of Health Pere Virgili (IISPV), 43204 Reus, Spain
2. Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University, 72300 Siteia, Greece
Interests: nutrition; lifestyle behaviors; epidemiology; metabolomics; cardiometabolic diseases; dementia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in high-throughput metabolomics profiling have allowed epidemiology research to advance our understanding in relation to many aspects of human health. Nutritional epidemiology has not been an exception, and the integration of metabolomics into traditional nutritional research has already provided new functional insight into the role of nutrition in health. Furthermore, metabolomics holds considerable promise for discovering new biomarkers of nutrient intake that may more precisely define nutritional exposure, complementing self-report dietary assessment methods and providing better estimates of disease risk in epidemiological studies.

We are pleased to announce the launch of our third Special Issue, "Nutrition, Metabolites, and Human Health—3rd Edition". Building on the success of our previous Special Issues, this collection aims to showcase the latest research on the role of nutrition and metabolites in promoting human health. We encourage submissions of original research, narrative or systematic reviews, and meta-analyses that employ cutting-edge techniques such as metabolomics, and also other omics techniques, such as genomics and metagenomics. Specifically, we welcome contributions that investigate the relationship between nutrition and metabolomics, and other omics with health outcomes, through observational and interventional studies in human or animal models. 

Dr. Christopher Papandreou
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolomics
  • microbial metabolites
  • gut microbiota
  • diet
  • food
  • nutrition
  • aging
  • cardiometabolic outcomes
  • cancer

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Published Papers (1 paper)

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11 pages, 1685 KiB  
Brief Report
In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment
by Parisa Rafiei, Huda S. Mian, Shruthi H. Iyer, Samantha B. Draves, Stephanie A. Matthews, Daniel E. Rendon, Emma J. Neesen, Madeline Dunlay, McKenna Revis, Adrianna L. Glisan, Timothy A. Simeone and Kristina A. Simeone
Nutrients 2025, 17(11), 1824; https://doi.org/10.3390/nu17111824 - 28 May 2025
Viewed by 311
Abstract
Background/Objectives: Hyperexcitable neuronal activity associated with seizures may disrupt brain homeostasis resulting in abnormal glucose and nutrient management and metabolism. Specialized ependymal cells known as tanycytes line the third ventricle wall bridging communication between the brain, CSF, and blood. Despite their positional importance, [...] Read more.
Background/Objectives: Hyperexcitable neuronal activity associated with seizures may disrupt brain homeostasis resulting in abnormal glucose and nutrient management and metabolism. Specialized ependymal cells known as tanycytes line the third ventricle wall bridging communication between the brain, CSF, and blood. Despite their positional importance, whether tanycytes are impacted by epilepsy is unknown. Here, known protein markers of tanycytes were assessed in the Kcna1-null mouse model of genetic epilepsy with spontaneous recurrent seizures (SRS mice). Further, whether an anti-seizure metabolic ketogenic diet (KD), previously proven effective in SRS mice, restored protein levels was determined. Methods: Known tanycyte proteins, including glucose transporter 1 (GLUT1), glial fibrillary acidic protein (GFAP), and doublecortin (DCX, to determine potential neurogenic differences) were examined throughout the anterior–posterior axis of the third ventricle using immunofluorescent histochemistry. Results: Decreased GLUT1 immunoreactivity and elevated GFAP levels were found in the SRS cohorts. The number of neurogenic DCX-expressing cells did not differ. Two weeks of KD treatment reduced GFAP to WT levels. GLUT1 remained low in KD-treated SRS mice. Conclusions: These data suggest that the expression of proteins important for the structure and function of tanycytes is altered in preclinical epilepsy and is differentially restored with KD treatment. Whether tanycytes actively participate in the pathophysiology of epilepsy or associated comorbidities is an intriguing possibility given their integral role in brain homeostasis. Full article
(This article belongs to the Special Issue Nutrition, Metabolites, and Human Health—3rd Edition)
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