Adipose Tissue and Metabolic Disorders: The Impact of Diet on Diabetes and Beyond

This Special Issue will explore how dietary components influence the function of adipose tissue and contribute to the pathogenesis and prevention of metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. Adipose tissue plays a central role in systemic metabolism—not only as a site of energy storage, but also as an active endocrine organ. Recent advances highlight how different fat depots respond to nutritional stimuli in diverse and clinically relevant ways.

We welcome the submission of high-quality original research articles, reviews, and short communications that address the following topics:

• Dietary Modulation of Visceral and Subcutaneous Adipose Tissue Function

–            Impact of macronutrient composition on fat depot-specific metabolic outcomes

–            Role of dietary patterns (e.g., Mediterranean, ketogenic, plant-based diets)

• Metabolic Flexibility of Adipose Tissue in Response to Diet and Physical Activity

–            Nutrient-induced changes in mitochondrial function and substrate utilization

–            Synergistic effects of exercise and diet on adipocyte metabolism

• Postprandial Adipose Tissue Responses and Systemic Metabolic Regulation

–            Role of adipose tissue in glucose and lipid clearance after meals

–            Nutrient timing and its influence on adipose tissue dynamics

• Dietary Regulation of Adipokines and Inflammatory Signaling

–            Adiponectin, leptin, resistin, and novel adipokines in response to dietary factors

–            Anti-inflammatory diets and modulation of adipose-derived cytokines

• Micronutrients and Adipose Tissue: From Nutrient Sensing to Metabolic Control

–            Roles of vitamins (D, A, B12) and trace elements (zinc, selenium) in adipocyte health

–            Nutritional deficiencies and adipose tissue dysfunction

• Adipose Tissue Senescence and Dietary Interventions to Combat Adipoinflammation

–            Caloric restriction, fasting-mimicking diets, and senolytic nutrients

–            Role of senescent adipocytes in insulin resistance and chronic inflammation

• The Endocrine Role of Perivascular and Epicardial Adipose Tissue

–            Diet-induced changes in vascular-associated adipose tissue

–            Implications for cardiovascular disease and atherosclerosis

• Gut–Adipose Axis: Role of Diet and Microbiota in Adipose Tissue Metabolism

–            Influence of prebiotics, probiotics, and dietary fiber on adipose tissue function

–            Gut-derived metabolites (e.g., SCFAs, bile acids) and adipocyte signaling

• Nutritional Epigenomics and Transcriptomics of Adipose Tissue

–            Diet-induced epigenetic changes affecting adipogenesis and metabolic gene expression

–            Nutrient–gene interactions in adipose tissue remodeling

• Translational and Clinical Studies: Dietary Interventions in Adipose-Driven Metabolic Diseases

–            Human trials investigating diet-based therapies for obesity and diabetes

–            Biomarkers of the adipose tissue response to nutritional interventions

Please upload your submissions through the Nutrients submission system, selecting the Special Issue title during submission. All manuscripts will be peer-reviewed and published with rapid turnaround. Nutrients is an international, peer-reviewed open access journal published by MDPI, with an Impact Factor of 5.9 (2023). The journal ensures the high visibility and global accessibility of your research.

We look forward to your contributions to this important topic at the intersection of nutrition, adipose biology, and metabolic disease. For inquiries, please contact the Editorial Office or Dr. Krzysztof Czaja directly via the Special Issue webpage.

Dr. Krzysztof Czaja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• diet
• visceral
• metabolic disorders
• adipose tissue
• biomarkers
• diabetes
• obesity
• free fatty acids
• body mass index
• body composition
• microbiome