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Female Reproductive Cancer: Nutrition and Wellness Perspectives

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: closed (25 May 2026) | Viewed by 1724

Special Issue Editors


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Guest Editor
Department of Clinical Science and Community Medicine, University of Milan, 20122 Milan, Italy
Interests: reproduction; gynecological disease; diet; epidemiology; risk factors
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Clinical Science and Community Medicine, University of Milan, 20122 Milan, Italy
Interests: reproduction; pregnancy outcomes; perinatal care; epidemiology; risk factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Female cancers, including breast and gynaecological malignancies, pose a significant threat to women’s health worldwide.

There is emerging evidence to suggest that diet plays a critical role in modulating cancer risk, progression and survivorship. Nutritional factors can affect key biological processes involved in the development of cancer, such as cell proliferation, apoptosis, inflammation, hormone regulation and immune function.

A healthy, balanced diet rich in fruits, vegetables, whole grains, legumes, and lean proteins may support immune function, improve tolerance to treatments, aid recovery, and potentially reduce the risk of recurrence. For example, higher intake of cruciferous vegetables and dietary fiber has been associated with reduced breast cancer risk in some epidemiological studies, while diets high in saturated fats and processed foods may exacerbate inflammation and tumor progression.

Although dietary supplements can help to address specific nutrient deficiencies, they should be used with caution and on a personalised basis. Incorporating nutrition into wider strategies for reproductive health, cancer prevention and survivorship can improve quality of life and clinical outcomes.

The aim of this Special Issue is to explore the links between diet and female cancers, including their risk, prevention, and progression, from epidemiological, molecular, and clinical perspectives. We will consider both original research and comprehensive meta-analyses or systematic reviews.

Prof. Dr. Fabio Parazzini
Dr. Giovanna Esposito
Guest Editors

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Keywords

  • female reproductive cancer
  • nutrition intervention
  • dietary pattern
  • wellness
  • gynecological oncology
  • nutritional support
  • reproductive health
  • post-treatment wellness
  • dietary supplements
  • breast cancer
  • ovarian cancer
  • cervical cancer
  • endometrial cancer

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Published Papers (1 paper)

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Research

13 pages, 381 KB  
Article
Plant-Based Diets and Ovarian Cancer Risk
by Giovanna Esposito, Federica Turati, Silvia Mignozzi, Fabio Parazzini, Livia S. A. Augustin, Sara Vitale, Jerry Polesel, Luigino Dal Maso, Eva Negri and Carlo La Vecchia
Nutrients 2026, 18(3), 536; https://doi.org/10.3390/nu18030536 - 5 Feb 2026
Cited by 2 | Viewed by 1453
Abstract
Objective: To assess the relationship between adherence to various plant-based diets, as measured by overall, healthy, and unhealthy plant-based diet indices (PDI, hPDI, uPDI), and ovarian cancer risk. Methods: We obtained data on 1031 cases of ovarian cancer and 2411 controls [...] Read more.
Objective: To assess the relationship between adherence to various plant-based diets, as measured by overall, healthy, and unhealthy plant-based diet indices (PDI, hPDI, uPDI), and ovarian cancer risk. Methods: We obtained data on 1031 cases of ovarian cancer and 2411 controls from a case-control study conducted in Italy. PDI, hPDI, and uPDI were calculated using data from a validated food frequency questionnaire. We used logistic regression to calculate the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) of ovarian cancer for PDI, hPDI, and uPDI, adjusting for several possible confounders. Results: PDI and hPDI were inversely related to ovarian cancer risk (OR = 0.70 for the fourth compared to the first quartile, 95% CI: 0.55–0.89, and OR = 0.67, 95% CI: 0.53–0.84, respectively). On the other hand, a higher uPDI was related to a higher risk of ovarian cancer (OR = 1.78, 95% CI: 1.40–2.28). The estimates for a 5-point increment in the indices were 0.88 (95% CI: 0.81–0.95) for PDI, 0.90 (95% CI: 0.83–0.96) for hPDI, and 1.15 (95% CI: 1.07–1.23) for uPDI. Consistent associations for the three indices were observed across strata of age, family history of breast/ovarian cancer, educational level, parity, oral contraceptives use, and menopausal status. Conclusions: Plant-based diets favorably influence ovarian cancer risk; plant-based diets characterized by a high intake of unhealthy plant foods are linked to an increased risk. Promoting diets rich in healthy plant foods could support the reduction of ovarian cancer risk. Full article
(This article belongs to the Special Issue Female Reproductive Cancer: Nutrition and Wellness Perspectives)
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