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Selenium and Iodine in Human Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 189

Special Issue Editors


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Guest Editor
Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Kraków, Poland
Interests: thyroid; iodine; selenium; vegetarian diet

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Guest Editor
Department of Food Chemistry and Toxicology, Berlin Institute of Technology, Straße des 17. Juni 135, 10623 Berlin, Germany
Interests: bioavailability, speciation and detection of trace metals; molecular mechanisms of the toxicity of metal ions; zinc as a second messenger

Special Issue Information

Dear Colleagues,

Iodine and selenium trace elements are crucial for maintaining proper thyroid function. However, their biological impact on the human body is much broader. Therefore, an inadequate supply can result in more than just disorder of the thyroid gland.

The scope of this Special Issue includes research on the importance of selenium and iodine for specific systems/organs, both in physiological state and in the course of disease. We would encourage publication of research related to nutritional aspects as well as supplementation.

This Special Issue of Nutrients, titled “Selenium and Iodine in Human Health and Disease”, welcomes original research and reviews of the literature concerning this important topic.

Dr. Jadwiga Kryczyk-Kozioł
Prof. Dr. Hajo Haase
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • selenium
  • iodine
  • diet
  • supplements
  • health
  • risk factors
  • disease

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Published Papers (1 paper)

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Research

13 pages, 416 KiB  
Article
Iodine and Selenium Status in Relation to Thyroid and Immune Functions—The Analysis of Their Dependencies in a Group of Women of Reproductive Age from the Southern Region of Poland
by Jadwiga Kryczyk-Kozioł, Ewelina Prochownik, Justyna Dobrowolska-Iwanek, Paweł Paśko, Krzysztof Kleszcz, Renata Francik, Halina Potok, Magdalena Nieckula, Urszula Cisoń-Apanasewicz, Paulina Jabłońska, Dorota Ogonowska, Grażyna Kuzera, Mirosław Krośniak, Sanja Klobučar and Paweł Zagrodzki
Nutrients 2025, 17(12), 1952; https://doi.org/10.3390/nu17121952 - 7 Jun 2025
Viewed by 111
Abstract
Objectives: Iodine and selenium are key elements for thyroid. There is also evidence of their immunoregulatory potential. However, the current state of knowledge of potential interactions among iodine—selenium—thyroid—immune system is not sufficient. The aim of the study was to evaluate iodine and selenium [...] Read more.
Objectives: Iodine and selenium are key elements for thyroid. There is also evidence of their immunoregulatory potential. However, the current state of knowledge of potential interactions among iodine—selenium—thyroid—immune system is not sufficient. The aim of the study was to evaluate iodine and selenium statuses and examine the relationship between them and the functioning of the thyroid and immune system in a group of women of reproductive age, without previously diagnosed disease. Methods: The study involved a group of 60 women aged 19–40 from southern Poland. The concentrations of iodine and selenium were determined in serum samples using the ICP-MS and AAS methods, respectively. Thyroid function was assessed by determining serum levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), and anti-thyroid peroxidase antibodies (anti-TPO) by electrochemiluminescence methods. Glutathione peroxidase 3 (GPX3) and ferric ion reducing antioxidant power (FRAP) in serum were measured by spectrophotometric methods. Immune functions were evaluated by analyzing cytokine levels using ELISA tests, including interferon-γ, interleukin-4, interleukin-17, and transforming growth factor-β. Results: No significant correlations between selenium and thyroid or immunological parameters were observed. The level of iodine in serum positively correlated with free thyroxine, indicating its importance for maintaining normal thyroid function, as well as with FRAP in serum, suggesting a protective role of iodine-mediated antioxidant activity on thyroid function. Conclusions: Our results underline the complexity of the system of correlations between iodine–selenium–thyroid–immune function. Nevertheless, understanding them may turn out to be crucial for developing preventive and therapeutic strategies in the context of thyroid diseases. Full article
(This article belongs to the Special Issue Selenium and Iodine in Human Health and Disease)
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