Probiotics, Gut Microbiota, and Metabolic Health: From Mechanisms to Therapeutics

Dear Colleagues,

The gut microbiota stands as a critical interface between our internal milieu and the external environment, playing an indispensable role in maintaining host nutritional metabolism and systemic health. Dysbiosis of the gut microbial ecosystem is increasingly recognized as a pivotal contributor to a wide spectrum of metabolic disorders.

While the association between gut microbiota and metabolic health is well established, the underlying mechanisms remain incompletely understood. It is crucial to understand how nutrition and diet shape microbial community structure and function, and how these changes are transduced into host signals that modulate immune responses, energy homeostasis, and organ function. The molecular links—including microbial metabolites, endocrine signals, and neural pathways—that connect gut microbes to improved host metabolic phenotypes are under intense investigation.

This Special Issue aims to bridge the gap between fundamental mechanistic insights and therapeutic applications. We welcome submissions of original research articles and comprehensive reviews that explore the tripartite relationship among probiotics, gut microbiota, and metabolic health. We are particularly interested in studies that unravel the causal mechanisms and demonstrate translational potential.

Topics of interest include, but are not limited to:

• Mechanisms of Action by which gut microbiota affects metabolism and Key Microbial Metabolites.
• Cross-Talk of Probiotics and Host Systems.
• The Gut–Organ Axis in Metabolism.
• Clinical and Pre-clinical Evidence about gut microbiota and metabolic health.
• Next-Generation Probiotics.

Dr. Dandan Han
Dr. Xiaolong Gu
Guest Editors

Manuscript Submission Information

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