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Nutrients
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Diet and Prevention of Alzheimer’s Disease or Age-Related Cognitive Decline
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Diet and Prevention of Alzheimer’s Disease or Age-Related Cognitive Decline

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (28 July 2023) | Viewed by 9065

Special Issue Editors

Dr. Vincenza Frisardi

E-Mail Website
Guest Editor
Geriatric Unit, Neuro-Rehabilitation Department, AUSL-IRCCS Reggio Emilia, 46123 Reggio Emilia, Italy
Interests: biological psychiatry; geriatrics and gerontology; physical therapy; sports therapy and rehabilitation
Dr. Emanuele Rocco Villani

E-Mail Website
Co-Guest Editor
1. UOC Geriatra - Disturbi Cognitivi e Demenze, Dipartimento di Cure Primarie. AUSL Modena, 41012 Modena, Italy
2. Department of Geriatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy
Interests: modifiable lifestyle factors and plasma biomarkers of Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Fabbo

E-Mail Website
Co-Guest Editor
Geriatric Service—Cognitive Disorders and Dementia, Department of Primary Care, Health Authority and Services of Modena, 41124 Modena, Italy
Interests: dementia care and management; nonpharmacological approach to behavioral disorders in dementia

Special Issue Information

Dear Colleagues,

This Research Topic’s primary goal is to increase our knowledge of the role of diet in the prevention of age-related cognitive decline, with a particular focus on Alzheimer’s Disease neuropathology, by exploring underpinning mechanisms to characterize dietary pattern and lifestyle factors able to counteract the dreadful consequences of aging. Furthermore, we want to give space to innovative research on the biological mechanisms of nutrients for therapeutic use, not only for cognitive disorders but also for the management of AD-related behavioral disturbance.

Finally, because neuropathological changes occur decades before the onset of clinical manifestation of cognitive disorders, we encourage authors to describe the impact of diet in terms of lifespan perspective. Our overarching aim is to build a comprehensive framework where theory, diverse methodological analyses, perspectives and new technological advancements could converge.

This Research Topic aims to stimulate research and give a multi-layered pyramidal perspective on diet, covering various critical points (in particular, whether the Mediterranean Diet still feasible in a fast-evolving society, and whether current “healthy foods” are still valid in the prevention of AD pathology). We encourage authors to explore the topic under the lens of a gender- and ethnicity-oriented personalized nutrition.

We welcome reviews (systematic and narrative) and mini reviews, original research papers (in vitro and in vivo), perspective papers, hypothesis and theory papers, methods papers and case reports.

Dr. Vincenza Frisardi
Dr. Emanuele Rocco Villani
Dr. Andrea Fabbo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • dietary pattern
  • age-related cognitive decline
  • Alzheimer’s disease
  • neuropathology
  • cognitive frailty
  • eating behavior

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Published Papers (2 papers)

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Research

16 pages, 742 KiB  
Article
Effect of Mediterranean Dietary Pattern on Cognitive Status in Community-Dwelling Older Adults
by Nathalie Yaghi, Rita El Hayeck, Christa Boulos, Marianne Abifadel and César Yaghi
Nutrients 2023, 15(18), 3911; https://doi.org/10.3390/nu15183911 - 8 Sep 2023
Viewed by 1837
Abstract
Modifiable factors associated with cognitive decline (CD) require more attention, particularly dietary patterns. This study aimed to investigate the link between cognitive decline and associated factors, particularly dietary patterns (DPs), in community-dwelling older Lebanese of modest economic status. Our cross-sectional national study included [...] Read more.
Modifiable factors associated with cognitive decline (CD) require more attention, particularly dietary patterns. This study aimed to investigate the link between cognitive decline and associated factors, particularly dietary patterns (DPs), in community-dwelling older Lebanese of modest economic status. Our cross-sectional national study included 352 participants above 60 years old, from the medico-social centers of the ministry of social affairs all over the country. CD was screened based on literacy. Nutritional and dietary data were collected through a validated food frequency questionnaire. DPs were extracted by the K-mean cluster analysis. CD was found in 32.7% and 61.5% of literate and illiterate groups, respectively. Identified DPs included a Westernized type and Mediterranean type, with high and moderate food intakes. In the context of literacy, independent factors associated with CD were age above 80 years, living in Beirut, frailty, and adopting a Westernized (OR = 3.08, 95% CI: 1.22–7.8) and a high-intake Mediterranean DP (OR = 2.11, 95% CI: 1.05–4.22). In the context of illiteracy, the same factors were associated with CD, but not DP nor frailty, with an age cut-off at 78 years. In a Lebanese sample of older adults, factors associated with CD depend on the level of literacy, with DP only associated with CD in the context of literacy. Full article
(This article belongs to the Special Issue Diet and Prevention of Alzheimer’s Disease or Age-Related Cognitive Decline)
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14 pages, 293 KiB  
Article
Study of Diet Habits and Cognitive Function in the Chinese Middle-Aged and Elderly Population: The Association between Folic Acid, B Vitamins, Vitamin D, Coenzyme Q10 Supplementation and Cognitive Ability
by Xinting Jiang, Yihan Guo, Liang Cui, Lin Huang, Qihao Guo and Gaozhong Huang
Nutrients 2023, 15(5), 1243; https://doi.org/10.3390/nu15051243 - 1 Mar 2023
Cited by 17 | Viewed by 6767
Abstract
A growing body of evidence suggests that vitamin supplements play a role in the prevention of cognitive decline. The objective of the present cross-sectional study was to evaluate the relationship between cognitive ability and folic acid, B vitamins, vitamin D (VD) and Coenzyme [...] Read more.
A growing body of evidence suggests that vitamin supplements play a role in the prevention of cognitive decline. The objective of the present cross-sectional study was to evaluate the relationship between cognitive ability and folic acid, B vitamins, vitamin D (VD) and Coenzyme Q10 (CoQ10) supplementation. The sample consisted of 892 adults aged above 50 who were assessed for their cognitive status in the Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (China) from July 2019 to January 2022. According to the degree of cognitive impairment, the subjects were divided into a normal control (NC) group, subjective cognitive decline (SCD) group, mild cognitive impairment (MCI) group and Alzheimer’s disease (AD) group. The results indicated a lower risk of AD in the daily VD-supplemented subjects with MCI compared to those who were not supplemented; a lower risk of cognitive impairment in those with normal cognitive who consumed VD, folic acid or CoQ10 on a daily basis compared those who did not; and a lower risk of cognitive impairment in subjects with normal cognitive performance who consumed B vitamin supplements, either daily or occasionally, compared to those who did not. The correlation was independent of other factors that potentially affect cognition, such as education level, age, etc. In conclusion, our findings confirmed a lower prevalence of cognitive impairment in those who took vitamins (folic acid, B vitamins, VD, CoQ10) daily. Therefore, we would recommend daily supplementation of vitamins (folic acid, B vitamins, VD, CoQ10), especially group B vitamins, as a potential preventive measure to slow cognitive decline and neurodegeneration in the elderly. However, for the elderly who have already suffered from cognitive impairment, VD supplementation may also be beneficial for their brains. Full article
(This article belongs to the Special Issue Diet and Prevention of Alzheimer’s Disease or Age-Related Cognitive Decline)
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