Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
10.2
5.8
Journals
Nutrients
Special Issues
Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the...
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle

A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Nutrition and Obesity".

Deadline for manuscript submissions: closed (25 May 2026) | Viewed by 3790

Editors

Dr. Cristian Álvarez

E-Mail Website
Guest Editor
Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile
Interests: physical exercise and vasculature in hypertension and type 2 diabetes; responders and non-responders to physical exercise; lifestyles and multiculturality risk factors; epidemiology of physical inactivity in health and disease
Special Issues, Collections and Topics in MDPI journals
Dr. Pedro Delgado-Floody

E-Mail Website
Guest Editor
1. Department of Physical Education, Sport and Recreation, University of La Frontera, Temuco 4811230, Chile
2. Strength & Conditioning Laboratory, CTS-642 Research Group, University of Granada, 18011 Granada, Spain
Interests: physical activity; lifestyle; physical exercise intervention; mental health; academic achievements
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite all those research colleagues interested in reporting the results of their studies to our next Special Issue entitled “Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle”.

In this issue, we would like to invite studies of different lifestyle strategies, including (but not limited to) physical exercise interventions, dietary interventions, their combination, or others for the rehabilitation of the obese condition and at the vascular level, and of those specific areas involved, such as cardiorespiratory fitness, muscle strength, and their effects on the vascular system. Studies on populations with diabetes, arterial hypertension, metabolic syndrome, fatty liver, kidney disease, and cancer will be especially welcome. Similarly, vascular abnormalities under the context of obesity, including endothelial dysfunction, peripheral vascular disease, and atherosclerotic populations, are also welcome.

Our Special Issue welcomes different types of studies, including descriptive, cohort, and longitudinal studies, but especially those of the experimental type in humans and preferably including different clinical and performance variables to report results of clinical and health variables as well as physical fitness and nutritional status in the following areas:

  • Obesity-related metabolic or vascular abnormalities;
  • Diet interventions for obesity-related conditions;
  • Nutritional and physical activity interventions in non-communicable diseases;
  • Exercise training and nutritional support in obesity-related vascular conditions;
  • Nutritional education for health promotion.

This Special Issue of Nutrients, entitled “Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle”, welcomes original research and reviews of the literature concerning this important topic.

Dr. Cristian Álvarez
Dr. Pedro Delgado-Floody
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • diabetes
  • high blood pressure
  • hypertension
  • diet
  • nutrition
  • physical activity
  • health promotion
  • lifestyle
  • exercise training

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

26 pages, 4227 KB  
Article
Sex-Specific Cytokine Responses and Metabolic Adaptation to Weight Loss in Obesity with Insulin Resistance
by Maria Dydoń, Anna Birková, Paweł Dolibog, Beáta Čižmárová, Beáta Hubková, Zenon Czuba, Paulina Zalejska-Fiolka, Agata Dydoń, Sławomir Kasperczyk, Bronisława Skrzep-Poloczek and Jolanta Zalejska-Fiolka
Nutrients 2026, 18(12), 1982; https://doi.org/10.3390/nu18121982 - 18 Jun 2026
Viewed by 1223
Abstract
Background/Objectives: Obesity-related insulin resistance is accompanied by chronic low-grade inflammation, but the extent to which weight loss modifies circulating cytokines in a sex-specific manner remains insufficiently understood. The aim of this study was to assess sex-specific cytokine responses and metabolic adaptation in [...] Read more.
Background/Objectives: Obesity-related insulin resistance is accompanied by chronic low-grade inflammation, but the extent to which weight loss modifies circulating cytokines in a sex-specific manner remains insufficiently understood. The aim of this study was to assess sex-specific cytokine responses and metabolic adaptation in adults with obesity and insulin resistance following a six-month weight-reduction program (WRP). Methods: Thirty-six participants (24 women and 12 men) with a value of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) ≥ 2 underwent an individualized low-calorie diet combined with moderate physical activity and health education. Anthropometric, body composition, biochemical, oxidative stress, and cytokine parameters were evaluated before and after the intervention. Results: Both women and men showed significant reductions in body mass, Body Mass Index (BMI), waist circumference, visceral fat area (VFA), body fat mass (BFM), fasting glucose, HOMA-IR, modified Atherogenic Index of Plasma (new-AIP), malondialdehyde (MDA), and Oxidative Stress Index (OSI). Women additionally showed significant decreases in fat-free mass (FFM), skeletal-muscle mass (SMM), total body water (TBW), glycated hemoglobin A1c (HbA1c), and triacylglycerols, whereas cholesterol in high-density lipoproteins (HDL-C) increased significantly in men. Cytokine changes were selective rather than uniform. Interleukin-1 receptor antagonist (IL-1ra), Interleukin 6 (IL-6), and Tumor Necrosis Factor alpha (TNF-α) decreased in both women and men. In sex-stratified analyses, IL-1β decreased significantly only in women, whereas IL-7 decreased significantly only in men. ClinicalTrials.gov Registration: [NCT07645105] (retrospectively registered on [11 June 2026]). Conclusions: A 6-month lifestyle-based weight-reduction program in adults with overweight or obesity and insulin resistance was associated with metabolic improvement, reduced oxidative stress, and partial attenuation of obesity-related low-grade inflammation. The observed cytokine and metabolic changes suggest sex-related patterns of immunometabolic adaptation to weight reduction. However, these findings should be interpreted cautiously because of the relatively small sex-stratified subgroups and the number of cytokine endpoints analyzed, and they require confirmation in larger, sex-balanced studies. Full article
(This article belongs to the Special Issue Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle)
►▼ Show Figures

Figure 1

18 pages, 2271 KB  
Article
Effects of Concurrent Training on Resting and Progressive Exercise Metabolism in Breast Cancer Survivors with Metabolic Syndrome Risk Factors
by Cristian Álvarez, Alejandra Soto, Valeska Subiábre, Paulina Ibacache-Saavedra, Luis Peñailillo, Cristóbal Durán-Marín, Igor Cigarroa, Cézane P. Reuter, Anelise R. Gaya, Pedro Delgado-Floody, David C. Andrade, Emmanuel Gomes Ciolac, Mikel Izquierdo and Gabriel Rojas-Rojas
Nutrients 2026, 18(12), 1882; https://doi.org/10.3390/nu18121882 - 11 Jun 2026
Viewed by 874
Abstract
Background/Objectives: Cancer pathophysiology involves metabolic disturbances, and exercise improves muscle metabolism, but little is known about the effect of concurrent high-intensity interval plus resistance training (CTHIIT+RT) on the resting and exercise metabolism of breast cancer survivors with risk factors related [...] Read more.
Background/Objectives: Cancer pathophysiology involves metabolic disturbances, and exercise improves muscle metabolism, but little is known about the effect of concurrent high-intensity interval plus resistance training (CTHIIT+RT) on the resting and exercise metabolism of breast cancer survivors with risk factors related to metabolic syndrome (MetS). The purpose of this study was to determine the effects of 8 weeks of CTHIIT+RT on the fat and carbohydrate (CHO) metabolism during rest and progressive exercise post-exercise intervention in breast cancer survivors with histories of high- and low-volume chemotherapy. Methods: An experimental study was conducted in which (n = 21) women breast cancer survivors (age: 58.7 ± 8.7 years) were divided by history of high- (HVchemo, ≥8 to 16 sessions, n = 10) or low-volume (LVchemo, ≤7 chemo sessions, n = 11) chemotherapy. The fat (RFATox) and CHO oxidation during 10 min of resting was measured (i.e., including the area under curve [AUC] points within this time), as well as the fat (ExFATox) and CHO (ExCHOox) oxidation during progressive exercise, before and after 8 weeks of CTHIIT+RT by indirect calorimetry. Additionally, risk factors related to MetS were described from pre- to post-intervention. Results: At rest, the HVchemo group showed significant increases in the AUC of RFATox (∆ + 23.7, p < 0.0001), similar to the LVchemo group (∆ + 14.0, p < 0.0001). The HVchemo group showed significant increases in the AUC of RCHOox (∆ + 109.7, p < 0.0001), similar to the LVchemo group (∆ + 107.5, p < 0.0001). During progressive exercise, the ExFATox was increased in the HVchemo group (∆ + 0.12 g/min, p = 0.006), similar to the ExCHOox (∆ + 0.52 g/min, p = 0.013) of this group. The proportion of subjects categorized with MetS were significantly reduced in blood pressure, Glu and triglyceride components. Conclusions: Eight weeks of CTHIIT+RT may promote favorable metabolic and cardiometabolic adaptations in breast cancer survivors regardless of the chemotherapy exposure volume. However, these findings should be interpreted cautiously due to the small sample size and lack of a true non-exercise control group. Full article
(This article belongs to the Special Issue Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle)
►▼ Show Figures

Figure 1

19 pages, 944 KB  
Article
Association of Life’s Essential 8 with Hepatic Fibrosis, MASLD, and MetALD in the Framingham Heart Study
by Alejandro Campos, Tianyu Liu, Brenton Prescott, Jiantao Ma, Madeleine G. Haff, Maura E. Walker, Arpan Mohanty and Vanessa Xanthakis
Nutrients 2026, 18(8), 1276; https://doi.org/10.3390/nu18081276 - 17 Apr 2026
Viewed by 1079
Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and related fibrosis are increasingly prevalent conditions. The relation of the American Heart Association’s (AHA) cardiovascular health (CVH) metric Life’s Essential 8 (LE8) with MASLD, MetALD, and hepatic fibrosis [...] Read more.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and related fibrosis are increasingly prevalent conditions. The relation of the American Heart Association’s (AHA) cardiovascular health (CVH) metric Life’s Essential 8 (LE8) with MASLD, MetALD, and hepatic fibrosis remains unclear. We aimed to investigate the associations of CVH with MASLD, MetALD, and hepatic fibrosis. Methods: We defined significant hepatic fibrosis as a liver stiffness ≥8.2 kPa measured by vibration-controlled transient elastography. MASLD was defined as steatosis (controlled attenuation parameter of ≥274 dB/m) with ≥1 cardiometabolic risk factor and mild alcohol intake (≤140 g/week [women]; ≤210 g/week [men]). MetALD was defined as steatosis with ≥1 cardiometabolic risk factor and moderate alcohol intake (141–350 g/week [women]; 211–420 g/week [men]). Data from 2962 participants in the Framingham Heart Study (mean age 59 years, 57% women) were used in multivariable-adjusted logistic regression models, accounting for demographic and clinical covariates to relate CVH and liver outcomes. Results: Our study included 2704 participants with mild and 258 with moderate alcohol use. MASLD and MetALD prevalence was 34% and 40%, respectively, and 9% had significant hepatic fibrosis. Each 10-point increase in LE4 score (composite of diet, sleep health, physical activity, and smoking) was associated with 16% lower odds of MASLD (Odds Ratio [OR] 0.84; 95% CI: 0.80–0.90; p < 0.001) but not MetALD. Each 10-point increase in LE8 score was associated with 17% lower odds of hepatic fibrosis (OR 0.83; 95% CI: 0.78–0.89; p < 0.001). Conclusions: Better CVH is related to lower odds of MASLD and significant hepatic fibrosis. Full article
(This article belongs to the Special Issue Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop