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Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 727

Special Issue Editors


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Guest Editor
Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile
Interests: physical exercise and vasculature in hypertension and type 2 diabetes; responders and non-responders to physical exercise; lifestyles and mul-ti-culturality risk factors; epidemiology of physical inactivity in health and disease
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Physical Education, Sport and Recreation, University of La Frontera, Temuco 4811230, Chile
2. Strength & Conditioning Laboratory, CTS-642 Research Group, University of Granada, 18011 Granada, Spain
Interests: physical activity; lifestyle; physical exercise intervention; mental health; academic achievements
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite all those research colleagues interested in reporting the results of their studies to our next Special Issue entitled “Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle”.

In this issue, we would like to invite studies of different lifestyle strategies, including (but not limited to) physical exercise interventions, dietary interventions, their combination, or others for the rehabilitation of the obese condition and at the vascular level, and of those specific areas involved, such as cardiorespiratory fitness, muscle strength, and their effects on the vascular system. Studies on populations with diabetes, arterial hypertension, metabolic syndrome, fatty liver, kidney disease, and cancer will be especially welcome. Similarly, vascular abnormalities under the context of obesity, including endothelial dysfunction, peripheral vascular disease, and atherosclerotic populations, are also welcome.

Our Special Issue welcomes different types of studies, including descriptive, cohort, and longitudinal studies, but especially those of the experimental type in humans and preferably including different clinical and performance variables to report results of clinical and health variables as well as physical fitness and nutritional status in the following areas:

  • Obesity-related metabolic or vascular abnormalities;
  • Diet interventions for obesity-related conditions;
  • Nutritional and physical activity interventions in non-communicable diseases;
  • Exercise training and nutritional support in obesity-related vascular conditions;
  • Nutritional education for health promotion.

This Special Issue of Nutrients, entitled “Lifestyle Interventions for Obesity-Related Metabolic and Vascular Disturbances Through the Life Cycle”, welcomes original research and reviews of the literature concerning this important topic.

Dr. Cristian Álvarez
Dr. Pedro Delgado-Floody
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • diabetes
  • high blood pressure
  • hypertension
  • diet
  • nutrition
  • physical activity
  • health promotion
  • lifestyle
  • exercise training

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Published Papers (1 paper)

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Research

19 pages, 944 KB  
Article
Association of Life’s Essential 8 with Hepatic Fibrosis, MASLD, and MetALD in the Framingham Heart Study
by Alejandro Campos, Tianyu Liu, Brenton Prescott, Jiantao Ma, Madeleine G. Haff, Maura E. Walker, Arpan Mohanty and Vanessa Xanthakis
Nutrients 2026, 18(8), 1276; https://doi.org/10.3390/nu18081276 - 17 Apr 2026
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Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and related fibrosis are increasingly prevalent conditions. The relation of the American Heart Association’s (AHA) cardiovascular health (CVH) metric Life’s Essential 8 (LE8) with MASLD, MetALD, and hepatic fibrosis [...] Read more.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and related fibrosis are increasingly prevalent conditions. The relation of the American Heart Association’s (AHA) cardiovascular health (CVH) metric Life’s Essential 8 (LE8) with MASLD, MetALD, and hepatic fibrosis remains unclear. We aimed to investigate the associations of CVH with MASLD, MetALD, and hepatic fibrosis. Methods: We defined significant hepatic fibrosis as a liver stiffness ≥8.2 kPa measured by vibration-controlled transient elastography. MASLD was defined as steatosis (controlled attenuation parameter of ≥274 dB/m) with ≥1 cardiometabolic risk factor and mild alcohol intake (≤140 g/week [women]; ≤210 g/week [men]). MetALD was defined as steatosis with ≥1 cardiometabolic risk factor and moderate alcohol intake (141–350 g/week [women]; 211–420 g/week [men]). Data from 2962 participants in the Framingham Heart Study (mean age 59 years, 57% women) were used in multivariable-adjusted logistic regression models, accounting for demographic and clinical covariates to relate CVH and liver outcomes. Results: Our study included 2704 participants with mild and 258 with moderate alcohol use. MASLD and MetALD prevalence was 34% and 40%, respectively, and 9% had significant hepatic fibrosis. Each 10-point increase in LE4 score (composite of diet, sleep health, physical activity, and smoking) was associated with 16% lower odds of MASLD (Odds Ratio [OR] 0.84; 95% CI: 0.80–0.90; p < 0.001) but not MetALD. Each 10-point increase in LE8 score was associated with 17% lower odds of hepatic fibrosis (OR 0.83; 95% CI: 0.78–0.89; p < 0.001). Conclusions: Better CVH is related to lower odds of MASLD and significant hepatic fibrosis. Full article
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