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Advances in Nutrition for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management: Current Perspectives from the Bench to the Bedside

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 1858

Special Issue Editor


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Guest Editor
Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: bioactive compounds; oxidative stress; MASLD; gut–liver axis; precision nutricion in MASLD; nutrigenomics and MASLD
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue in Nutrients welcomes leading experts and researchers to present the current research perspectives in nutrition focused on metabolic dysfunction-associated steatotic liver disease (MASLD, former non-alcoholic fatty liver disease (NAFLD)) management. MASLD gathers a spectrum of hepatic diseases, including simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, and MASH-related hepatocellular carcinoma (HCC). MASLD is the most common chronic liver disease worldwide, and it affects one quarter of the global population. Despite the increasing research in the area, changes in food habits and exercise are the main preventive strategy. The purpose of this call is to explore the current evidence in nutrition, which encompasses factors from basic research in molecular mechanisms of action of certain nutrients and bioactive compounds to nutritional guidelines recommended in clinical research to manage MASLD. Thus, this Special Issue aims to include original works and literature reviews that explore nutritional approaches with novel food bioactive compounds or functional foods, innovative dietary strategies based on precision nutrition, as well as dietary recommendations from randomised controlled trials focused on MASLD management.

Dr. Ildefonso Rodríguez-Ramiro
Guest Editor

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Keywords

  • metabolic dysfunction-associated steatotic liver disease (MASLD)
  • non-alcoholic fatty liver disease (NAFLD)
  • healthy diet
  • Mediterranean diet
  • functional food
  • bioactive compounds
  • precision nutrition
  • liver metabolism
  • nutrigenetics in MASLD
  • nutrigenomics in MASLD
  • nutritional guidelines in MASLD

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Published Papers (1 paper)

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Review

24 pages, 2267 KiB  
Review
Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review
by Deepa Handu, Kim Stote and Tami Piemonte
Nutrients 2025, 17(3), 453; https://doi.org/10.3390/nu17030453 - 26 Jan 2025
Cited by 2 | Viewed by 1576
Abstract
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition affecting a broad population. This review aimed to identify and summarize the current evidence on bioactive-substance-based interventions for adults with MASLD, formerly known as nonalcoholic fatty liver disease (NAFLD), covering publications [...] Read more.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition affecting a broad population. This review aimed to identify and summarize the current evidence on bioactive-substance-based interventions for adults with MASLD, formerly known as nonalcoholic fatty liver disease (NAFLD), covering publications from 2000 to 2023. Methods: A search was conducted across six databases (MEDLINE, CINAHL, Cochrane CENTRAL, Cochrane Database of Systematic Reviews, Food Science Source, and SPORTDiscus) for randomized controlled trials and other study types (e.g., prospective cohort studies and systematic reviews), reflecting the scoping nature of this review. The search was limited to studies in adults (>18 years old), with an intervention of interest and at least one comparator group. Results: A total of 4572 articles were retrieved, with 201 full-text articles screened for eligibility. Of these, 131 primary studies and 49 systematic reviews were included in the scoping review. The most studied bioactive substances were Curcumin (Turmeric) (n = 25), Silymarin (Milk Thistle) (n = 17), Resveratrol (n = 10), Coffee (n = 7), Green Tea (n = 5), and Berberine (n = 5 each). Moreover, 46 studies reported on 36 other bioactive substances with 2 or fewer articles each. Among the included systematic reviews, 13 focused on Curcumin, 12 on Coffee or Tea, 10 on bioactive substance combinations, 6 on Resveratrol, and 2 each on Silymarin and Artichoke Leaf. The included studies showed substantial heterogeneity in reported outcomes, which primarily focused on hepatic health, body weight, adverse events, glycemic control, blood lipids, and body composition. Conclusions: This scoping review highlights a range of bioactive substances used in the treatment of MASLD. While evidence is abundant for bioactive substances like Curcumin and Silymarin, further research and synthesis of findings is necessary to establish the clinical efficacy of all bioactive substances. Full article
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