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Nutrients
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Precision Dietary Management of Non-Alcoholic Fatty Liver Disease
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Precision Dietary Management of Non-Alcoholic Fatty Liver Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 431

Special Issue Editor

Dr. Fangfang Zeng

E-Mail Website
Guest Editor
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510086, China
Interests: nutrition epidemiology; liver disease; metabolic diseases; gut microbiome; dietary intake
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern, with a high prevalence worldwide largely due to poor dietary habits. Precision nutrition offers a promising approach to address the complex interplay between diet, genetics, metabolism, and gut microbiota in NAFLD management.

This Special Issue aims to explore the latest research on personalized dietary strategies for NAFLD prevention and treatment. We invite original research and reviews focusing on (1) the role of precision nutrition in understanding NAFLD pathophysiology and individual variability, (2) the impact of dietary patterns, nutrients, and bioactive compounds on NAFLD risk and progression, (3) innovative tools for monitoring dietary habits, food behaviors, and physical activity in NAFLD populations, (4) the application of nutrigenomics, metabolomics, and microbiota profiling to tailor dietary interventions for NAFLD prevention and control, and (5) the development of precision nutrition frameworks to implement effective dietary strategies at the population level. By integrating advances in multi-omics technologies and deep phenotyping, this Special Issue seeks to advance precision nutrition approaches for NAFLD and improve public health outcomes.

Dr. Fangfang Zeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision nutrition
  • non-alcoholic fatty liver disease
  • dietary management
  • nutrigenomics
  • metabolomics
  • gut microbiota
  • personalized diet

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Published Papers (1 paper)

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Research

17 pages, 1583 KiB  
Article
Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome
by Vittorio Scoppola, Annalisa Crudele, Antonella Mosca, Nadia Panera, Chiara di Camillo, Caterina Bock, Massimiliano Raponi, Alberto Villani, Anna Alisi and Diletta Valentini
Nutrients 2025, 17(14), 2331; https://doi.org/10.3390/nu17142331 - 16 Jul 2025
Viewed by 259
Abstract
Background/Objectives: We evaluated the efficacy of a good lifestyle intervention on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with Down syndrome (DS). Methods: This retrospective longitudinal study included 31 children with Down syndrome (DS) who were affected [...] Read more.
Background/Objectives: We evaluated the efficacy of a good lifestyle intervention on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with Down syndrome (DS). Methods: This retrospective longitudinal study included 31 children with Down syndrome (DS) who were affected by MASLD and attended nutritional counseling based on a nutritional approach (e.g., Mediterranean diet and antioxidant supplements), as well as physical exercise. Clinical parameters, markers of low-grade systemic inflammation, and hepatic steatosis, as assessed by ultrasound, were evaluated at baseline (T0) and after 6 months (T1). Results: Several anthropometric and biochemical parameters, including body mass index, waist circumference, diastolic and systolic blood pressure, aspartate aminotransferase, basal insulin, insulin resistance, pro-inflammatory interleukin-1β, and anti-inflammatory interleukin-10, showed significant improvement after 6 months of a nutritional approach. This study also found a regression of at least one grade of hepatic steatosis in a significant portion of patients, especially in those who received antioxidant supplements. Conclusions: Our study further supports the hypothesis that a healthy lifestyle intervention, based on adherence to the Mediterranean diet, natural supplements with antioxidant properties, and regular physical activity, can be considered a safe therapeutic approach for reducing the risk and severity of MASLD in children with DS. Full article
(This article belongs to the Special Issue Precision Dietary Management of Non-Alcoholic Fatty Liver Disease)
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