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Nutrients
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Nutritional Modulation in Aging and Metabolic Syndrome: Combating Obesity, Vascular...
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Nutritional Modulation in Aging and Metabolic Syndrome: Combating Obesity, Vascular Disease and Frailty

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 446

Special Issue Editors

Prof. Dr. Sérgio Henrique Sousa Santos

E-Mail Website
Guest Editor
1. Institute of Agricultural Sciences (ICA), Food Engineering, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil
2. Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil
Interests: metabolic syndrome; physical exercise; life quality; obesity; dyslipidemia
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Maik Gollasch

E-Mail Website
Co-Guest Editor
Department of Internal Medicine and Geriatrics, University Medicine Greifswald, Greifswald, Germany
Interests: cardiovascular disease; hypertension; geriatrics; nephrology; physiology
Dr. Carla Jeane-Aguiar

E-Mail Website
Co-Guest Editor
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Montes Claros, Minas Gerais, Brazil
Interests: cardiovascular; cell biology; molecular biology; cancer; metabolic syndrome
Dr. Daniele Teixeira Alves

E-Mail Website
Guest Editor Assistant
Department of Internal Medicine and Geriatrics, University Medicine Greifswald, Greifswald, Germany
Interests: molecular biology; vasoactive; cardiovascular disease; kidney disease; physiology

Special Issue Information

Dear Colleagues,

Metabolic syndrome (MetS) is a multifactorial disturbance characterized by a cluster of health issues that exacerbate one another, disrupting the body's homeostasis. Some of the main alterations include high blood pressure, diabetes, obesity, and abnormal cholesterol levels, which are commonly associated with cardiovascular diseases, the leading cause of death worldwide. MetS is also increasingly linked to age-related conditions such as frailty and the broader aging process, highlighting the importance of early prevention and targeted management in older adults. New nutritional, molecular, and mechanistic insights are crucial for developing innovative treatment options.

Metabolic syndrome, vascular diseases, frailty, and ageing are interconnected, collectively posing significant risks to both individual and public health. Nutritional interventions, exercise, functional foods, nutraceuticals, and other specific therapies are essential for preventing, reducing, and treating these conditions, ultimately improving quality of life and promoting healthy aging.

This Special Issue aims to gather original research articles and review papers that evaluate the clinical relevance, experimental approaches, and biological activities of nutraceuticals, plants, dietary interventions, isolated compounds/active principles, and the mechanisms involved in metabolic syndrome, vascular diseases, diabetes, dyslipidemia, frailty, aging, and related disorders.

Prof. Dr. Sérgio Henrique Sousa Santos
Prof. Dr. Maik Gollasch
Dr. Carla Jeane-Aguiar
Guest Editors

Dr. Daniele Teixeira Alves
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • physical exercise
  • life qualit
  • obesity
  • dyslipidemia
  • aging

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Published Papers (1 paper)

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Research

13 pages, 257 KiB  
Article
Associations of Multimarkers of Metabolic Malnutrition and Inflammation with All-Cause Mortality by Multimorbidity Status
by Setor K. Kunutsor, Reyhaneh Rikhtehgaran, Margery A. Connelly, Irina Shalaurova, Stephan J. L. Bakker and Robin P. F. Dullaart
Nutrients 2025, 17(11), 1747; https://doi.org/10.3390/nu17111747 - 22 May 2025
Viewed by 350
Abstract
Background/Objectives: The metabolic vulnerability index (MVX)—a composite biomarker reflecting metabolic malnutrition and inflammation—is associated with increased mortality risk, but its association across different levels of chronic disease burden has not been explored. We aimed to examine the associations of MVX and its [...] Read more.
Background/Objectives: The metabolic vulnerability index (MVX)—a composite biomarker reflecting metabolic malnutrition and inflammation—is associated with increased mortality risk, but its association across different levels of chronic disease burden has not been explored. We aimed to examine the associations of MVX and its subcomponents (Inflammation Vulnerability Index, IVX and Metabolic Malnutrition Index, MMX) with all-cause mortality according to multimorbidity status. Methods: In the PREVEND study, which included 6054 participants (mean age 54 years; 49.5% male), MVX was calculated using six plasma biomarkers measured simultaneously via nuclear magnetic resonance spectroscopy. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated. Results: During a median follow-up of 14.0 years, 911 deaths were recorded. In analyses adjusted for several established risk factors, the HRs (95% CIs) of mortality per 1 standard deviation increment in MVX were 1.32 (1.13–1.54; p < 0.001), 1.23 (1.08–1.40; p = 0.002), and 1.29 (1.16–1.43; p < 0.001) for individuals with no disease, one disease, and multimorbidity, respectively. The corresponding HRs (95% CIs) were 1.22 (1.05–1.42; p = 0.010), 1.17 (1.03–1.34; p = 0.015), and 1.25 (1.13–1.38; p < 0.001) for IVX and 1.29 (1.11–1.48; p = 0.001), 1.16 (1.02–1.31; p = 0.032), and 1.14 (1.03–1.25; p = 0.004) for MMX. The ratio of HRs showed no statistical evidence that sex modified the associations of MVX, IVX, and MMX with mortality in each multimorbidity category. However, the associations appeared stronger in males with chronic disease and in females without chronic conditions, suggesting possible sex-related trends. Conclusions: MVX, IVX, and MMX are independent risk indicators of all-cause mortality regardless of the burden of chronic disease, with MVX showing the strongest associations across different multimorbidity statuses. MMX should be interpreted as a proxy for metabolic malnutrition rather than a direct nutritional assessment tool. Full article
(This article belongs to the Special Issue Nutritional Modulation in Aging and Metabolic Syndrome: Combating Obesity, Vascular Disease and Frailty)
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