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Effects of Dietary Polysaccharides and Their Molecular Mechanisms

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Carbohydrates".

Deadline for manuscript submissions: closed (25 June 2025) | Viewed by 405

Special Issue Editors


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Guest Editor
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: polysaccharides; starch; dietary fiber; functionality; protein
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: dietary polysaccharides; hypoglycemic; hypolipidemic; anti-inflammatory; gut microbiota; functional foods
Special Issues, Collections and Topics in MDPI journals
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
Interests: polysaccharide; protein; drug delivery; functional foods; molecular mechanism

Special Issue Information

Dear Colleagues,

Since the start of this century, an interesting trend has emerged in nutraceutical discovery, namely an understanding of the adsorption mechanism of functional molecules as a strategy to develop health-beneficial nutrients. Dietary polysaccharides have been demonstrated to possess a range of beneficial properties, including antioxidant, tumour-inhibiting, anti-allergic, immunomodulatory, hypoglycaemic, and prebiotic activities. However, the digestion and absorption of polysaccharides are influenced by a multitude of structural factors, including monosaccharide composition, molecular weight, type of glycosidic bond, degree of branching, and their interactions with enzymes, digestive fluids, intestinal epithelial cells, and probiotic surfaces. Therefore, it is of great significance to discover the absorption mechanisms of polysaccharide activity at a molecular level and to elucidate the relationship between these molecular mechanisms and their functionalities.

In this context, we welcome any papers related to this Special Issue in the following aspects:

- Health-promoting functions of new polysaccharides.
- The advanced characterizations and in silico studies on interactions between polysaccharides and cell receptors.
- Gut microbiota and metabonomics.
- The biological roles of polysaccharides in the gut barrier.

Dr. Xiang-Ze Jia
Dr. Chao Li
Dr. Di Wu
Guest Editors

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Keywords

  • dietary polysaccharides
  • mechanisms
  • functionality
  • gut microbiota
  • metabolic pathways
  • nutraceuticals

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Published Papers (1 paper)

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Research

19 pages, 2922 KiB  
Article
Identification, Antioxidant and Immunomodulatory Activities of a Neutral Exopolysaccharide from Lactiplantibacillus plantarum DMDL 9010
by Yanyan Huang, Weiting Liang, Yunhui Lu, Jie Xiong, Dongmei Liu and Xiangze Jia
Nutrients 2025, 17(14), 2265; https://doi.org/10.3390/nu17142265 - 9 Jul 2025
Viewed by 187
Abstract
Objectives: This study investigated the properties of a neutral exopolysaccharide (EPS-LP1) with an average molecular weight of 55,637 Da, isolated from Lactiplantibacillus plantarum DMDL 9010 (LP9010). Results: The composition of EPS-LP1 includes galactose (Gal), glucose (Glu) and mannose (Man) in a molar ratio [...] Read more.
Objectives: This study investigated the properties of a neutral exopolysaccharide (EPS-LP1) with an average molecular weight of 55,637 Da, isolated from Lactiplantibacillus plantarum DMDL 9010 (LP9010). Results: The composition of EPS-LP1 includes galactose (Gal), glucose (Glu) and mannose (Man) in a molar ratio of 5.35:86.25:8.40. Notably, EPS-LP1 exhibits a smooth and rod-like surface along with thermal stability. Methylation combined with nuclear magnetic resonance analysis revealed that EPS-LP1 structured as t-Galp(1→, →6)-Glcp(1→, 4)-Glcp(1→ and →4,6)-Galp(1→), with relative molar ratio of 1.016:9.874:4.355:78.693:6.062, respectively. In the concentration range of 50 to 400 mg/mL, we observed the absence of cytotoxic effects from EPS-LP1 on RAW264.7 cells. Furthermore, EPS-LP1 demonstrated protective effects on RAW264.7 cells against oxidative damage by reducing the production of reactive oxygen species (ROS), malondialdehyde (MDA), and lactate dehydrogenase (LDH) release. Conversely, an increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and concentrations of glutathione (GSH) was observed. Immunoreactivity assays indicated that EPS-LP1 can effectively reduce the production of nitric oxide (NO) and inhibit the secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Additionally, it inhibited the activation of the mitogen-activated protein kinase (MAPK)/nuclear factor-kappa B gene binding (NF-kB) signaling pathway. Conclusions: This research provides a foundation basis for further investigations into the neutral exopolysaccharide derived from LP9010. Full article
(This article belongs to the Special Issue Effects of Dietary Polysaccharides and Their Molecular Mechanisms)
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