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Special Issue "Measurement of Antioxidant Activity: Advances and Perspectives"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editors

Dr. José Pinela
Guest Editor
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Bragança, Portugal
Interests: Medicinal and Local Food Plants; Food Processing and Preservation; Biowaste Valorization; Optimization of Extraction Methods; Bio-based Ingredients; Bioactivity and Chemical Characterization of Natural Products
Special Issues and Collections in MDPI journals
Dr. Maria Ines Dias
Co-Guest Editor
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Bragança, Portugal
Interests: Medicinal and Aromatic Plants; Coloring natural compounds; Increased production of secondary metabolites through in vitro culture technique; Chromatographic methods in phenolic compounds analysis coupled with mass spectrometry; Bioactive properties and Chemical Characterization of natural matrices
Maria Inês Dias (F) is a Junior Researcher at CIMO-IPB since 04/2018. PhD in Sustainable Chemistry (2017, University of Porto, Portugal), MSc in Biotechnology (2011, IPB) and BSc in Biotechnological Engineering (2009, IPB). Co-author of 59 indexed (h-index 16) papers and 4 international book chapters. Participates in 5 R&I projects and collaborates with Nat. and Int. institutions. Co-author of 11 publications in proceedings, 32 oral communications (19 Int.), and 49 posters (18 Int.) in scientific meetings. Supervisor of MSc and BSc students. Member of the Young Chemists Group of the Portuguese Chemical Society. (ORCID: 0000-0001-8744-7814 e Scopus Author ID: 54388787000)
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Significant advances in recent years have brought major improvements in how to assess the antioxidant capacity of different samples, while serious questions about the chemistry, execution, and application of several assays have been raised among the scientific community.

Many analytical methods have been used for decades for antioxidant activity measurements with inadequate consideration of the reaction chemistry or kinetics and without addressing toxicity issues. Furthermore, the results obtained by chemical methods do not extrapolate the performance of the target sample in vivo, since the antioxidant action in biological systems occurs under complex physiological conditions. Additionally, does the term antioxidant equate to health benefits?

At this time, it is necessary to discontinue or improve some methodologies and to implement cellular and food model systems to accurately assess the biological or technological relevance of the antioxidant effect. The challenge is to standardize the analytical methods that have been developed and to demonstrate their robustness and flexibility and the actual meaning of the results at the in vivo level.

This Special Issue aims to bring together recent research and experience on measurement of antioxidant activity of synthetic and natural compounds and bio-based ingredients. We invite researchers to contribute original research and review articles on recent advances and applications in this field of antioxidant research that is receiving so much attention in the food, pharmaceutical, and biological sciences.

Prof. Isabel C.F.R. Ferreira
Dr. José Pinela
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Antioxidant activity
  • Cellular and food model systems
  • Chemical versus cellular methods
  • Chemistry and mechanisms of action
  • Antioxidant response modelling
  • Lipid peroxidation, prooxidants, and free radicals
  • Bioaccessibility and cytotoxicity

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title:  Antioxidant extracts of three species from genus Russula express diverse biological activity

Autorship: Marina Kostić 1, Marija Ivanov1, Ângela Fernandes, Ricardo C. Calhelha, Jasmina Glamočlija1, Lillian Barros2, Isabel C. F. R. Ferreira2, Ana Ćirić1,* and Marina Soković1  


1Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”, National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia; 

  2Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal


Title: A view on antioxidant activity determination of silver nanoparticles

Zdenka Bedlovičová1,*, Aneta Salayová1, Matej Baláž2

1 Department of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovakia

2 Department of Mechanochemistry, Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 040 01 Košice, Slovakia.

Corresponding author: Zdenka Bedlovičová, [email protected]

Abstract: Our objective in this review is to find a relevant information about methods of determination of antioxidant activity of silver nanoparticles. There are many studies dealing with mentioned problem and we would like to summarize knowledge about methods evaluating the antioxidant activity of silver nanoparticles critically. Many authors declare better antioxidant activity of silver nanoparticles compared to the extract. In this review, we focused on methods of antioxidant activity determination in detail to find out novel and perspective methods to solve the general problems associated with antioxidant activity of nanoparticles.


Tentative title: “Caernohabditis elegans as a model organism to evaluate the antioxidant effects of phytochemicals"

Authors: Begoña Ayuda-Durán, Ana M. González-Paramás, Susana González-Manzano, Celestino Santos-Buelga*

Affiliation: Grupo de Investigación en Polifenoles (GIP-USAL), Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain

*Corresponding author: [email protected]

Abstract: The nematode C. elegans was introduced as a model organism in biological research by Sydney Brenner in the 1970’s. Since then, it has been increasingly used for investigating processes such as aging, oxidative stress, neurodegeneration, or inflammation, for which there is a high degree of homology between C. elegans and human pathways, so that the worm offers promising possibilities to study mechanisms of action and effects of secondary compounds of foods and plants. In this paper, the genes and pathways regulating oxidative stress in C. elegans will be discussed, as well as the methodological approaches used for their evaluation in the worm. In particular, the following aspects will be reviewed: the use of stress assays, determination of chemical and biochemical markers (e.g., ROS, carbonylated proteins, lipid peroxides or altered DNA), influence on gene expression and the employment of mutant worm strains, either carrying loss of function mutations or fluorescent reporters, such as the GFP.

Title: Enzymatic modification of Porphyra dioica-derived proteins to improve their antioxidant potential
Authors: Filipa B. Pimentel1; Maria Cermeño; Thanyaporn Kleekayai; Pádraigín A. Harnedy; E. Fernandes; Rita C. Alves; M. Beatriz P.P. Oliveira; Richard J. FitzGerald
Affiliation: 1. LAQV-REQUIMTE, University of Porto, Faculty of Pharmacy, Dep. Chemical Sciences, Porto, Portugal 2. Department of Biological Sciences, University of Limerick, Limerick (Ireland)

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