Special Issue "Aptamers: Successes, Limitations and Future Directions"
Deadline for manuscript submissions: 31 October 2019
Dr. Laura Cerchia
Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS) – National Research Council of Italy (CNR), Via S. Pansini 5, 80131 Naples, Italy
Website | E-Mail
Phone: + 39 0815455751
Interests: oligonucleotide aptamer, cell-SELEX technology, targeting delivery system, cancer biomarker discovery, cancer cell biology and signaling, targeted therapy, chemotherapy resistance, glioblastoma, triple-negative breast cancers
Aptamers, generated by the systematic evolution of ligands by exponential enrichment (SELEX) process, are short, artificial, single-stranded oligonucleotides that, similarly to antibodies, interact at high affinity with their targets by recognizing a specific three-dimensional structure. They offer suitable features for analytical, diagnostic, and therapeutic applications, including easy manufacturing and great reproducibility from batch-to-batch, structural stability, and low/absent immunogenicity. Because of their nucleic acid nature, the rational design of advanced strategies to manipulate aptamers for wide-ranging applications is greatly simplified over antibodies.
This Special Issue will include original research articles and review articles on all aspects of aptamer research, including aptamer selection technology, engineering/modification strategies, analytical applications, imaging modalities, nanotechnology, diagnostics, and therapeutics. It aims to attract contributions highlighting problems, solutions, and future directions in the development of aptamers as molecular recognition elements from basic research toward diverse commercial applications.
Dr. Laura Cerchia
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Aptamer diagnostics
- Aptamer therapeutics
- Aptamer imaging
- Aptamer sensors
- Aptamer nanotechnology
- Aptamer nanomedicine
- Targeted delivery systems
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
- Author: J. Carlos Penedo
Affiliation: University of St Andrews, SUPA School of Physics and Astronomy, St. Andrews, United Kingdom
- Type of the paper: Review
Tentative title: G-quadruplex-forming aptamers – characteristics, applications and perspectives
Authors: Carolina Roxo, Weronika Kotkowiak, Anna Pasternak
Affiliations: Department of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, PAS, Poznan, Poland
- Author: Yu. Ivanov, Tatyana Pleshakova
Affiliation: Bonn Pharmazeutisches Institut, Rheinische Friedrich-Wilhelms-Universität
Title: Aptamers for detection of Hepatite C virus particals by silicon nanowire field-effect-transistor
- Authors: Walhan Alshaer 1,*, Mohammad Ismail 2, Ezzaldin Alesawi 2, Hamdi Al Nusirat 3, Said I. Ismail 2,4
Affiliation: 1.Cell Therapy Center, The University of Jordan, Amman, Jordan; 2. Faculty of Medicine, The University of Jordan, Amman, Jordan; 3. Faculty of Science, The University of Jordan, Amman, Jordan; 4. Qatar Genome Project, Qatar Foundation, Doha, Qatar
Abstract: Soon after they were first described in 1990, Aptamers we largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic and therapeutic applications. Aptamers are short single stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind a large variety of target molecules ranging from small ions to whole cells. Their high binding specificity and affinity is comparable to antibodies but they are superior with regards to being easy to manufacture, having a long shelf life, simplistic chemical modification, in addition to low toxicity and immunogenicity. In the past 3 decades, aptamers have been used in a plethora of therapeutic and drug delivery systems that involve innovative delivery mechanisms and carrying various types of drug cargos. However, the successful translation of aptamers research from bench- to bedside has been challenged by several limitations that slowdown the realization of the promising aptamers applications as therapeutics at the clinical level. The main limitations include the susceptibility for degradation by nucleases, fast renal clearance, low thermal stability, and the limited functional groups diversity. The salvation of such limitations can be in the chemistry of aptamers. The currentreview will focus on the recent arts of aptamers chemistry that have been evolved to refine the pharmacological properties of aptamers. Moreover, this review will analyze advantages and disadvantages of such chemical modifications and how they impact the pharmacological properties of aptamers. Finally, this review will end with future directions that may improve the applications of aptamers in therapeutics.
Keywords: Aptamers, Drug delivery, Nanocarriers, chemical modifications.
- Author: Maria DeRosa
Affiliation: Chemistry Department, Carleton University, Ottawa, Ontario, Canada