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Special Issue "Amide Bond Activation"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 November 2018

Special Issue Editor

Guest Editor
Prof. Dr. Michal Szostak

Department of Chemistry, Rutgers University, 73 Warren St, Newark, NJ 07102, United States
Website | E-Mail
Interests: homogeneous catalysis; organometallic chemistry; N–C activation; amide bonds; cross-coupling; C–H activation; N-heterocyclic carbenes; single electron transfer; synthetic methods; transition metal catalysis

Special Issue Information

Dear Colleagues,

The amide bond represents a privileged motif in chemistry. One fascinating feature of the amide bond is the innate stability achieved by delocalization of the nitrogen lone pair into the carbonyl group. Defying conventional knowledge that characterizes the amide bond as one of the most robust functional groups in synthetic chemistry, recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. An important trend involves chemoselective activation of the N–C amide bond by metal insertion. This thriving class of reactions originates from the classic studies on amide bond destabilization and has a potential to become widely applicable cross-coupling platform. More generally, N–C bond activation emphasizes the significance of ubiquitous amide bonds to participate in a wide range of electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. These methods are beneficial to chemists because they supply valuable compounds by functional group interconversion or functionalization of amides on the fundamental level. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This Special Issue aims to provide a broad survey of recent advances in activation of amides and address various approaches in the field. This Special Issue will contain contributions describing multifaceted aspects of this area. Reviews articles by experts in the field are also welcome.

Prof. Dr. Michal Szostak
Guest Editor

Manuscript Submission Information

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Keywords

  • Amides
  • Amide bond
  • Bond functionalization
  • Functional group interconversion
  • Organic synthesis
  • Cross-coupling
  • Catalysis
  • N–C activation
  • Esters
  • O–C activation
  • Resonance
  • Planarity
  • Winkler-Dunitz parameters
  • Twisted amides

Published Papers (15 papers)

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Research

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Open AccessArticle Computational Study of Mechanism and Thermodynamics of Ni/IPr-Catalyzed Amidation of Esters
Molecules 2018, 23(10), 2681; https://doi.org/10.3390/molecules23102681
Received: 21 September 2018 / Revised: 12 October 2018 / Accepted: 12 October 2018 / Published: 18 October 2018
Cited by 1 | PDF Full-text (2334 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Nickel catalysis has shown remarkable potential in amide C–N bond activation and functionalization. Particularly for the transformation between ester and amide, nickel catalysis has realized both the forward (ester to amide) and reverse (amide to ester) reactions, allowing a powerful approach for the
[...] Read more.
Nickel catalysis has shown remarkable potential in amide C–N bond activation and functionalization. Particularly for the transformation between ester and amide, nickel catalysis has realized both the forward (ester to amide) and reverse (amide to ester) reactions, allowing a powerful approach for the ester and amide synthesis. Based on density functional theory (DFT) calculations, we explored the mechanism and thermodynamics of Ni/IPr-catalyzed amidation with both aromatic and aliphatic esters. The reaction follows the general cross-coupling mechanism, involving sequential oxidative addition, proton transfer, and reductive elimination. The calculations indicated the reversible nature of amidation, which highlights the importance of reaction thermodynamics in related reaction designs. To shed light on the control of thermodynamics, we also investigated the thermodynamic free energy changes of amidation with a series of esters and amides. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties
Molecules 2018, 23(10), 2608; https://doi.org/10.3390/molecules23102608
Received: 29 August 2018 / Revised: 2 October 2018 / Accepted: 10 October 2018 / Published: 11 October 2018
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Abstract
To investigate the amino acid transporter-based prodrug anticancer strategy further, several amino acid-conjugated amide gemcitabine prodrugs were synthesized to target amino acid transporters in pancreatic cancer cells. The structures of the synthesized amino acid-conjugated prodrugs were confirmed by 1H-NMR and LC-MS. The
[...] Read more.
To investigate the amino acid transporter-based prodrug anticancer strategy further, several amino acid-conjugated amide gemcitabine prodrugs were synthesized to target amino acid transporters in pancreatic cancer cells. The structures of the synthesized amino acid-conjugated prodrugs were confirmed by 1H-NMR and LC-MS. The pancreatic cancer cells, AsPC1, BxPC-3, PANC-1 and MIAPaCa-2, appeared to overexpress the amino acid transporter LAT-1 by conventional RT-PCR. Among the six amino acid derivatives of gemcitabine, threonine derivative of gemcitabine (Gem-Thr) was more effective than free gemcitabine in the pancreatic cancer cells, BxPC-3 and MIAPaCa-2, respectively, in terms of anti-cancer effects. Furthermore, Gem-Thr was metabolically stable in PBS (pH 7.4), rat plasma and liver microsomal fractions. When Gem-Thr was administered to rats at 4 mg/kg i.v., Gem-Thr was found to be successfully converted to gemcitabine via amide bond cleavage. Moreover, the Gem-Thr showed the increased systemic exposure of formed gemcitabine by 1.83-fold, compared to free gemcitabine treatment, due to the significantly decreased total clearance (0.60 vs. 4.23 mL/min/kg), indicating that the amide prodrug approach improves the metabolic stability of gemcitabine in vivo. Taken together, the amino acid transporter-targeting gemcitabine prodrug, Gem-Thr, was found to be effective on pancreatic cancer cells and to offer an efficient potential means of treating pancreatic cancer with significantly better pharmacokinetic characteristics than gemcitabine. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization
Molecules 2018, 23(10), 2455; https://doi.org/10.3390/molecules23102455
Received: 1 September 2018 / Revised: 21 September 2018 / Accepted: 21 September 2018 / Published: 25 September 2018
Cited by 1 | PDF Full-text (5644 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis. In recently described QM studies of cis/trans isomerization
[...] Read more.
Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis. In recently described QM studies of cis/trans isomerization in secondary amides using density functional methods, we highlighted that a peptidic prototype, such as glycylglycine methyl ester, can suitably represent the isomerization and complexities arising out of a larger molecular backbone, and can serve as the primary scaffold for model structures with different substitution patterns in order to assess and compare the steric effect of the substitution patterns. Here, we describe our theoretical assessment of such steric effects using tert-butyl as a representative bulky substitution. We analyze the geometries and relative stabilities of both trans and cis isomers, and effects on the cis/trans isomerization barrier. We also use the additivity principle to calculate absolute steric effects with a gradual increase in bulk. The study establishes that bulky substitutions significantly destabilize cis isomers and also increases the isomerization barrier, thereby synergistically hindering the cis/trans isomerization of secondary amides. These results provide a basis for the rationalization of kinetic and thermodynamic properties of peptides with potential applications in synthetic and medicinal chemistry. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessCommunication Ruthenium-Based Catalytic Systems Incorporating a Labile Cyclooctadiene Ligand with N-Heterocyclic Carbene Precursors for the Atom-Economic Alcohol Amidation Using Amines
Molecules 2018, 23(10), 2413; https://doi.org/10.3390/molecules23102413
Received: 29 August 2018 / Revised: 17 September 2018 / Accepted: 18 September 2018 / Published: 20 September 2018
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Abstract
Transition-metal-catalyzed amide-bond formation from alcohols and amines is an atom-economic and eco-friendly route. Herein, we identified a highly active in situ N-heterocyclic carbene (NHC)/ruthenium (Ru) catalytic system for this amide synthesis. Various substrates, including sterically hindered ones, could be directly transformed into
[...] Read more.
Transition-metal-catalyzed amide-bond formation from alcohols and amines is an atom-economic and eco-friendly route. Herein, we identified a highly active in situ N-heterocyclic carbene (NHC)/ruthenium (Ru) catalytic system for this amide synthesis. Various substrates, including sterically hindered ones, could be directly transformed into the corresponding amides with the catalyst loading as low as 0.25 mol.%. In this system, we replaced the p-cymene ligand of the Ru source with a relatively labile cyclooctadiene (cod) ligand so as to more efficiently obtain the corresponding poly-carbene Ru species. Expectedly, the weaker cod ligand could be more easily substituted with multiple mono-NHC ligands. Further high-resolution mass spectrometry (HRMS) analyses revealed that two tetra-carbene complexes were probably generated from the in situ catalytic system. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Palladium-Catalyzed Room Temperature Acylative Cross-Coupling of Activated Amides with Trialkylboranes
Molecules 2018, 23(10), 2412; https://doi.org/10.3390/molecules23102412
Received: 23 August 2018 / Revised: 16 September 2018 / Accepted: 18 September 2018 / Published: 20 September 2018
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Abstract
A highly efficient acylative cross-coupling of trialkylboranes with activated amides has been effected at room temperature to give the corresponding alkyl ketones in good to excellent yields by using 1,3-bis(2,6-diisopropyl)phenylimidazolylidene and 3-chloropyridine co-supported palladium chloride, the PEPPSI catalyst, in the presence of K
[...] Read more.
A highly efficient acylative cross-coupling of trialkylboranes with activated amides has been effected at room temperature to give the corresponding alkyl ketones in good to excellent yields by using 1,3-bis(2,6-diisopropyl)phenylimidazolylidene and 3-chloropyridine co-supported palladium chloride, the PEPPSI catalyst, in the presence of K2CO3 in methyl tert-butyl ether. The scope and limitations of the protocol were investigated, showing good tolerance of acyl, cyano, and ester functional groups in the amide counterpart while halo group competed via the classical Suzuki coupling. The trialkylboranes generated in situ by hydroboration of olefins with BH3 or 9-BBN performed similarly to those separately prepared, making this protocol more practical. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold
Molecules 2018, 23(9), 2363; https://doi.org/10.3390/molecules23092363
Received: 25 August 2018 / Revised: 10 September 2018 / Accepted: 12 September 2018 / Published: 15 September 2018
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Abstract
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported. Non-planar amides are generally sensitive to water or other nucleophiles, so that the amide bond is
[...] Read more.
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported. Non-planar amides are generally sensitive to water or other nucleophiles, so that the amide bond is readily cleaved. In this article, we examine the reactivity profile of the base-catalyzed hydrolysis of 7-azabicyclo[2.2.1]heptane amides, which show pyramidalization of the amide nitrogen atom, and we compare the kinetics of the base-catalyzed hydrolysis of the benzamides of 7-azabicyclo[2.2.1]heptane and related monocyclic compounds. Unexpectedly, non-planar amides based on the 7-azabicyclo[2.2.1]heptane scaffold were found to be resistant to base-catalyzed hydrolysis. The calculated Gibbs free energies were consistent with this experimental finding. The contribution of thermal corrections (entropy term, –TΔS) was large; the entropy term (ΔS) took a large negative value, indicating significant order in the transition structure, which includes solvating water molecules. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Electronic Effect on the Molecular Motion of Aromatic Amides: Combined Studies Using VT-NMR and Quantum Calculations
Molecules 2018, 23(9), 2294; https://doi.org/10.3390/molecules23092294
Received: 6 August 2018 / Revised: 4 September 2018 / Accepted: 4 September 2018 / Published: 8 September 2018
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Abstract
Rotational barrier energy studies to date have focused on the amide bond of aromatic compounds from a kinetic perspective using quantum calculations and nuclear magnetic resonance (NMR). These studies provide valuable information, not only regarding the basic conformational properties of amide bonds but
[...] Read more.
Rotational barrier energy studies to date have focused on the amide bond of aromatic compounds from a kinetic perspective using quantum calculations and nuclear magnetic resonance (NMR). These studies provide valuable information, not only regarding the basic conformational properties of amide bonds but also the molecular gear system, which has recently gained interest. Thus, we investigate the precise motion of the amide bonds of two aromatic compounds using an experimental rotational barrier energy estimation by NMR experiments and a theoretical evaluation of the density functional theory calculation. The theoretical potential energy surface scan method combined with the quadratic synchronous transit 3 method and consideration of additional functional group rotation with optimization and frequency calculations support the results of the variable temperature 1H NMR, with deviations of less than 1 kcal/mol. This detailed experimental and theoretical research strongly supports molecular gear motion in the aromatic amide system, and the difference in kinetic energy indicates that the electronic effect from the aromatic structure has a key role in conformational movements at different temperatures. Our study provides an enhanced basis for future amide structural dynamics research. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source
Molecules 2018, 23(9), 2225; https://doi.org/10.3390/molecules23092225
Received: 30 July 2018 / Revised: 24 August 2018 / Accepted: 29 August 2018 / Published: 1 September 2018
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Abstract
Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and
[...] Read more.
Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessArticle Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors
Molecules 2018, 23(7), 1724; https://doi.org/10.3390/molecules23071724
Received: 3 July 2018 / Revised: 10 July 2018 / Accepted: 11 July 2018 / Published: 14 July 2018
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Abstract
Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4af, potential Michael acceptors, and their reduced analogues succindiamides 5af were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl fumarate (1a) or mono-methyl succinate (1b
[...] Read more.
Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4af, potential Michael acceptors, and their reduced analogues succindiamides 5af were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl fumarate (1a) or mono-methyl succinate (1b), hydrolysis of PQ-dicarboxylic acid mono-ester conjugates 2a,b to corresponding acids 3a,b, and a coupling reaction with halogenanilines. 1-[bis(Dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) was used as a coupling reagent along with Hünig′s base. Compounds 4 and 5 were evaluated against a panel of bacteria, several Mycobacterium strains, fungi, a set of viruses, and nine different human tumor cell lines. p-Chlorofumardiamide 4d showed significant activity against Staphylococcus aureus,Streptococcus pneumoniae and Acinetobacter baumannii, but also against Candida albicans (minimum inhibitory concentration (MIC) 6.1–12.5 µg/mL). Together with p-fluoro and p-CF3 fumardiamides 4b,f, compound 4d showed activity against Mycobacterium marinum and 4b,f against M. tuberculosis. In biofilm eradication assay, most of the bacteria, particularly S. aureus, showed susceptibility to fumardiamides. m-CF3 and m-chloroaniline fumardiamides 4e and 4c showed significant antiviral activity against reovirus-1, sindbis virus and Punta Toro virus (EC50 = 3.1–5.5 µM), while 4e was active against coxsackie virus B4 (EC50 = 3.1 µM). m-Fluoro derivative 4a exerted significant cytostatic activity (IC50 = 5.7–31.2 μM). Acute lymphoblastic leukemia cells were highly susceptible towards m-substituted derivatives 4a,c,e (IC50 = 6.7–8.9 μM). Biological evaluations revealed that fumardiamides 4 were more active than succindiamides 5 indicating importance of Michael conjugated system. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Review

Jump to: Research

Open AccessReview Amide Activation in Ground and Excited States
Molecules 2018, 23(11), 2859; https://doi.org/10.3390/molecules23112859
Received: 4 October 2018 / Revised: 26 October 2018 / Accepted: 31 October 2018 / Published: 2 November 2018
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Abstract
Not all amide bonds are created equally. The purpose of the present paper is the reinterpretation of the amide group by means of two concepts: amidicity and carbonylicity. These concepts are meant to provide a new viewpoint in defining the stability and reactivity
[...] Read more.
Not all amide bonds are created equally. The purpose of the present paper is the reinterpretation of the amide group by means of two concepts: amidicity and carbonylicity. These concepts are meant to provide a new viewpoint in defining the stability and reactivity of amides. With the help of simple quantum-chemical calculations, practicing chemists can easily predict the outcome of a desired process. The main benefit of the concepts is their simplicity. They provide intuitive, but quasi-thermodynamic data, making them a practical rule of thumb for routine use. In the current paper we demonstrate the performance of our methods to describe the chemical character of an amide bond strength and the way of its activation methods. Examples include transamidation, acyl transfer and amide reductions. Also, the method is highly capable for simple interpretation of mechanisms for biological processes, such as protein splicing and drug mechanisms. Finally, we demonstrate how these methods can provide information about photo-activation of amides, through the examples of two caged neurotransmitter derivatives. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessReview Heteroatom Substitution at Amide Nitrogen—Resonance Reduction and HERON Reactions of Anomeric Amides
Molecules 2018, 23(11), 2834; https://doi.org/10.3390/molecules23112834
Received: 6 October 2018 / Revised: 23 October 2018 / Accepted: 24 October 2018 / Published: 31 October 2018
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Abstract
This review describes how resonance in amides is greatly affected upon substitution at nitrogen by two electronegative atoms. Nitrogen becomes strongly pyramidal and resonance stabilisation, evaluated computationally, can be reduced to as little as 50% that of N,N-dimethylacetamide. However, this
[...] Read more.
This review describes how resonance in amides is greatly affected upon substitution at nitrogen by two electronegative atoms. Nitrogen becomes strongly pyramidal and resonance stabilisation, evaluated computationally, can be reduced to as little as 50% that of N,N-dimethylacetamide. However, this occurs without significant twisting about the amide bond, which is borne out both experimentally and theoretically. In certain configurations, reduced resonance and pronounced anomeric effects between heteroatom substituents are instrumental in driving the HERON (Heteroatom Rearrangement On Nitrogen) reaction, in which the more electronegative atom migrates from nitrogen to the carbonyl carbon in concert with heterolysis of the amide bond, to generate acyl derivatives and heteroatom-substituted nitrenes. In other cases the anomeric effect facilitates SN1 and SN2 reactivity at the amide nitrogen. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessReview Amide Bond Activation of Biological Molecules
Molecules 2018, 23(10), 2615; https://doi.org/10.3390/molecules23102615
Received: 7 September 2018 / Revised: 9 October 2018 / Accepted: 9 October 2018 / Published: 12 October 2018
Cited by 1 | PDF Full-text (10917 KB) | HTML Full-text | XML Full-text
Abstract
Amide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and adopt particular three-dimensional
[...] Read more.
Amide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and adopt particular three-dimensional structures, which, in turn, are responsible for their functions. The main focus of this review article is to report the methodologies for the activation of the unactivated amide bonds present in biomolecules, which includes the enzymatic approach, metal complexes, and non-metal based methods. This article also discusses some of the applications of amide bond activation approaches in the sequencing of proteins and the synthesis of peptide acids, esters, amides, and thioesters. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessReview Direct Transamidation Reactions: Mechanism and Recent Advances
Molecules 2018, 23(9), 2382; https://doi.org/10.3390/molecules23092382
Received: 24 August 2018 / Revised: 12 September 2018 / Accepted: 13 September 2018 / Published: 18 September 2018
Cited by 1 | PDF Full-text (5877 KB) | HTML Full-text | XML Full-text
Abstract
Amides are undeniably some of the most important compounds in Nature and the chemical industry, being present in biomolecules, materials, pharmaceuticals and many other substances. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, principally the use of stoichiometric activators or
[...] Read more.
Amides are undeniably some of the most important compounds in Nature and the chemical industry, being present in biomolecules, materials, pharmaceuticals and many other substances. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, principally the use of stoichiometric activators or the need to use highly reactive carboxylic acid derivatives. In recent years, the transamidation reaction has emerged as a valuable alternative to prepare amides. The reactivity of amides makes their direct reaction with nitrogen nucleophiles difficult; thus, the direct transamidation reaction needs a catalyst in order to activate the amide moiety and to promote the completion of the reaction because equilibrium is established. In this review, we present research on direct transamidation reactions ranging from studies of the mechanism to the recent developments of more applicable and versatile methodologies, emphasizing those reactions involving activation with metal catalysts. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessReview Transition-Metal-Free Activation of Amide Bond by Arynes
Molecules 2018, 23(9), 2145; https://doi.org/10.3390/molecules23092145
Received: 3 August 2018 / Revised: 20 August 2018 / Accepted: 24 August 2018 / Published: 27 August 2018
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Abstract
Highly reactive arynes activate the N–C and C=O bonds of amide groups under transition metal-free conditions. This review highlights the insertion of arynes into the N–C and C=O bonds of the amide group. The insertion of arynes into the N–C bond gives the
[...] Read more.
Highly reactive arynes activate the N–C and C=O bonds of amide groups under transition metal-free conditions. This review highlights the insertion of arynes into the N–C and C=O bonds of the amide group. The insertion of arynes into the N–C bond gives the unstable four-membered ring intermediates, which are easily converted into ortho-disubstituted arenes. On the other hand, the selective insertion of arynes into the C=O bond is observed when the sterically less-hindered formamides are employed to give a reactive transient intermediate. Therefore, the trapping reactions of transient intermediates with a variety of reactants lead to the formation of oxygen atom-containing heterocycles. As relative functional groups are activated, the reactions of arynes with sulfinamides, phosphoryl amides, cyanamides, sulfonamides, thioureas, and vinylogous amides are also summarized. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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Open AccessFeature PaperReview Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents
Molecules 2018, 23(8), 1939; https://doi.org/10.3390/molecules23081939
Received: 13 July 2018 / Revised: 30 July 2018 / Accepted: 31 July 2018 / Published: 3 August 2018
PDF Full-text (16221 KB) | HTML Full-text | XML Full-text
Abstract
N,N-Dimethylformamide and N,N-dimethylacetamide are multipurpose reagents which deliver their own H, C, N and O atoms for the synthesis of a variety of compounds under a number of different experimental conditions. The review mainly highlights the corresponding
[...] Read more.
N,N-Dimethylformamide and N,N-dimethylacetamide are multipurpose reagents which deliver their own H, C, N and O atoms for the synthesis of a variety of compounds under a number of different experimental conditions. The review mainly highlights the corresponding literature published over the last years. Full article
(This article belongs to the Special Issue Amide Bond Activation)
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