Special Issue "Amide Bond Activation"
Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 145515
A printed edition of this Special Issue is available here.
Interests: amide bonds; N-heterocyclic carbenes; C-N activation; C-H activation; C-O activation; lanthanides; cross-coupling; catalysis; reductions; reductive couplings; radical chemistry; synthetic methodology; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue in Organics: Feature Papers in Organics
Special Issue in Molecules: Amide Bond Activation II
Special Issue in International Journal of Molecular Sciences: Sulfonamides as a Potent Anti-Cancer Agents
Topical Collection in Organics: Advanced Research Papers in Organics
Special Issue in Molecules: Synthetic Transformations of Amides and Esters in Organic Synthesis
The amide bond represents a privileged motif in chemistry. One fascinating feature of the amide bond is the innate stability achieved by delocalization of the nitrogen lone pair into the carbonyl group. Defying conventional knowledge that characterizes the amide bond as one of the most robust functional groups in synthetic chemistry, recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. An important trend involves chemoselective activation of the N–C amide bond by metal insertion. This thriving class of reactions originates from the classic studies on amide bond destabilization and has a potential to become widely applicable cross-coupling platform. More generally, N–C bond activation emphasizes the significance of ubiquitous amide bonds to participate in a wide range of electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. These methods are beneficial to chemists because they supply valuable compounds by functional group interconversion or functionalization of amides on the fundamental level. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This Special Issue aims to provide a broad survey of recent advances in activation of amides and address various approaches in the field. This Special Issue will contain contributions describing multifaceted aspects of this area. Reviews articles by experts in the field are also welcome.
Prof. Dr. Michal Szostak
Manuscript Submission Information
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- Amide bond
- Bond functionalization
- Functional group interconversion
- Organic synthesis
- N–C activation
- O–C activation
- Winkler-Dunitz parameters
- Twisted amides