Amide Activation in Ground and Excited States
AbstractNot all amide bonds are created equally. The purpose of the present paper is the reinterpretation of the amide group by means of two concepts: amidicity and carbonylicity. These concepts are meant to provide a new viewpoint in defining the stability and reactivity of amides. With the help of simple quantum-chemical calculations, practicing chemists can easily predict the outcome of a desired process. The main benefit of the concepts is their simplicity. They provide intuitive, but quasi-thermodynamic data, making them a practical rule of thumb for routine use. In the current paper we demonstrate the performance of our methods to describe the chemical character of an amide bond strength and the way of its activation methods. Examples include transamidation, acyl transfer and amide reductions. Also, the method is highly capable for simple interpretation of mechanisms for biological processes, such as protein splicing and drug mechanisms. Finally, we demonstrate how these methods can provide information about photo-activation of amides, through the examples of two caged neurotransmitter derivatives. View Full-Text
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Kovács, E.; Rózsa, B.; Csomos, A.; Csizmadia, I.G.; Mucsi, Z. Amide Activation in Ground and Excited States. Molecules 2018, 23, 2859.
Kovács E, Rózsa B, Csomos A, Csizmadia IG, Mucsi Z. Amide Activation in Ground and Excited States. Molecules. 2018; 23(11):2859.Chicago/Turabian Style
Kovács, Ervin; Rózsa, Balázs; Csomos, Attila; Csizmadia, Imre G.; Mucsi, Zoltán. 2018. "Amide Activation in Ground and Excited States." Molecules 23, no. 11: 2859.
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